hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00845
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SRSF5 | Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) | UniProt NCBI |
| SRSF4 | Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4) | UniProt NCBI |
| SRSF6 | Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2589 | 2.25356268047e-10 | 1.0 | SRSF4 SRSF5 SRSF6 | PGC-1-SRp40-SRp55-SRp75 complex |
| KEGG:03040 | 1.07586932974e-05 | 1.0 | SRSF4 SRSF5 SRSF6 | Spliceosome |
| REAC:R-HSA-72187 | 1.11518017806e-05 | 1.0 | SRSF4 SRSF5 SRSF6 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 1.78539429329e-05 | 1.0 | SRSF4 SRSF5 SRSF6 | RNA Polymerase II Transcription Termination |
| WP:WP411 | 2.0466384774e-05 | 1.0 | SRSF4 SRSF5 SRSF6 | mRNA Processing |
| REAC:R-HSA-159236 | 2.2531998792e-05 | 1.0 | SRSF4 SRSF5 SRSF6 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-72202 | 3.28880140401e-05 | 1.0 | SRSF4 SRSF5 SRSF6 | Transport of Mature Transcript to Cytoplasm |
| CORUM:351 | 0.000100864958453 | 1.0 | SRSF4 SRSF5 SRSF6 | Spliceosome |
| GO:0045292 | 0.000265644334868 | 1.0 | SRSF4 SRSF5 SRSF6 | mRNA cis splicing, via spliceosome |
| KEGG:05168 | 0.0002707003734 | 1.0 | SRSF4 SRSF5 SRSF6 | Herpes simplex virus 1 infection |
| REAC:R-HSA-72163 | 0.000415506674825 | 1.0 | SRSF4 SRSF5 SRSF6 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.000474432644369 | 1.0 | SRSF4 SRSF5 SRSF6 | mRNA Splicing |
| REAC:R-HSA-72203 | 0.000960089475622 | 1.0 | SRSF4 SRSF5 SRSF6 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0000381 | 0.00295242108794 | 1.0 | SRSF4 SRSF5 SRSF6 | regulation of alternative mRNA splicing, via spliceosome |
| GO:0000380 | 0.00435066388439 | 1.0 | SRSF4 SRSF5 SRSF6 | alternative mRNA splicing, via spliceosome |
| GO:0048024 | 0.00865355719779 | 1.0 | SRSF4 SRSF5 SRSF6 | regulation of mRNA splicing, via spliceosome |
| GO:0031124 | 0.0117851633362 | 1.0 | SRSF4 SRSF5 SRSF6 | mRNA 3'-end processing |
| GO:0006406 | 0.0180261250619 | 1.0 | SRSF4 SRSF5 SRSF6 | mRNA export from nucleus |
| GO:0071427 | 0.0180261250619 | 1.0 | SRSF4 SRSF5 SRSF6 | mRNA-containing ribonucleoprotein complex export from nucleus |
| REAC:R-HSA-8953854 | 0.0206735000409 | 1.0 | SRSF4 SRSF5 SRSF6 | Metabolism of RNA |
| GO:0051028 | 0.0206993698472 | 1.0 | SRSF4 SRSF5 SRSF6 | mRNA transport |
| GO:0043484 | 0.0255054888903 | 1.0 | SRSF4 SRSF5 SRSF6 | regulation of RNA splicing |
| GO:0050684 | 0.0261539335231 | 1.0 | SRSF4 SRSF5 SRSF6 | regulation of mRNA processing |
| GO:0071426 | 0.0268132763851 | 1.0 | SRSF4 SRSF5 SRSF6 | ribonucleoprotein complex export from nucleus |
| GO:0071166 | 0.0274836082947 | 1.0 | SRSF4 SRSF5 SRSF6 | ribonucleoprotein complex localization |
| HPA:004010_13 | 0.0329176593671 | 0.666666666667 | SRSF4 SRSF6 | breast; adipocytes[Supported,High] |
| GO:0006405 | 0.033252767518 | 1.0 | SRSF4 SRSF5 SRSF6 | RNA export from nucleus |
| GO:0031123 | 0.0356085105614 | 1.0 | SRSF4 SRSF5 SRSF6 | RNA 3'-end processing |
| CORUM:6073 | 0.0499776345577 | 0.333333333333 | SRSF6 | SRSF9-SRSF6 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SRSF5 | SRSF6 | 0.988 | 0.901 | bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM |
| SRSF4 | SRSF6 | 0.978 | 0.893 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SRSF5 | SRSF4 | 0.937 | 0.85 | bioplex_WMM boldt youn_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_00845 has an average edge precision of 0.881 which is ranked 651 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SRSF5 | HuMAP2_00041 HuMAP2_00845 HuMAP2_02572 HuMAP2_03584 HuMAP2_04668 |
| SRSF4 | HuMAP2_00845 HuMAP2_02572 HuMAP2_03584 HuMAP2_04668 |
| SRSF6 | HuMAP2_00845 HuMAP2_02572 HuMAP2_03584 HuMAP2_04668 |