hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00852
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMURF1 | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | UniProt NCBI |
| SMURF2 | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04340 | 0.000138019076752 | 1.0 | SMURF2 SMURF1 | Hedgehog signaling pathway |
| WP:WP4249 | 0.000261924676198 | 1.0 | SMURF2 SMURF1 | Hedgehog Signaling Pathway |
| REAC:R-HSA-2173788 | 0.000351943927099 | 1.0 | SMURF2 SMURF1 | Downregulation of TGF-beta receptor signaling |
| REAC:R-HSA-201451 | 0.000424008635981 | 1.0 | SMURF2 SMURF1 | Signaling by BMP |
| KEGG:04350 | 0.000438130325039 | 1.0 | SMURF2 SMURF1 | TGF-beta signaling pathway |
| REAC:R-HSA-2173789 | 0.000588249135293 | 1.0 | SMURF2 SMURF1 | TGF-beta receptor signaling activates SMADs |
| KEGG:04120 | 0.00122335090758 | 1.0 | SMURF2 SMURF1 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-8941858 | 0.00230942253115 | 1.0 | SMURF2 SMURF1 | Regulation of RUNX3 expression and activity |
| WP:WP366 | 0.00284130523568 | 1.0 | SMURF2 SMURF1 | TGF-beta Signaling Pathway |
| REAC:R-HSA-4608870 | 0.00327307852202 | 1.0 | SMURF2 SMURF1 | Asymmetric localization of PCP proteins |
| REAC:R-HSA-170834 | 0.00381775364729 | 1.0 | SMURF2 SMURF1 | Signaling by TGF-beta Receptor Complex |
| KEGG:04144 | 0.00387576825996 | 1.0 | SMURF2 SMURF1 | Endocytosis |
| GO:0030579 | 0.00450823411379 | 1.0 | SMURF2 SMURF1 | ubiquitin-dependent SMAD protein catabolic process |
| REAC:R-HSA-5632684 | 0.0052959181411 | 1.0 | SMURF2 SMURF1 | Hedgehog 'on' state |
| REAC:R-HSA-9006936 | 0.00656291627866 | 1.0 | SMURF2 SMURF1 | Signaling by TGF-beta family members |
| REAC:R-HSA-4086400 | 0.00686290657842 | 1.0 | SMURF2 SMURF1 | PCP/CE pathway |
| REAC:R-HSA-8878159 | 0.0070154156135 | 1.0 | SMURF2 SMURF1 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-3858494 | 0.0156129029755 | 1.0 | SMURF2 SMURF1 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-5358351 | 0.0167776697818 | 1.0 | SMURF2 SMURF1 | Signaling by Hedgehog |
| CORUM:2992 | 0.0249595281251 | 0.5 | SMURF2 | Ubiquitin E3 ligase (SMAD7, SMURF2) |
| CORUM:2996 | 0.0249595281251 | 0.5 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) |
| CORUM:1783 | 0.0499173803268 | 0.5 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) - TGFBR1 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMURF1 | SMURF2 | 1.0 | 0.949 | bioplex (SMURF2) bioplex_WMM |
Images
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Complex HuMAP2_00852 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SMURF1 | HuMAP2_00852 HuMAP2_01252 HuMAP2_02752 HuMAP2_03627 HuMAP2_04429 |
| SMURF2 | HuMAP2_00852 HuMAP2_01252 HuMAP2_02752 HuMAP2_04429 |