hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00854
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SCFD1 | Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) | UniProt NCBI |
| BNIP1 | Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) | UniProt NCBI |
| USE1 | Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31) | UniProt NCBI |
| SCFD2 | Sec1 family domain-containing protein 2 (Syntaxin-binding protein 1-like 1) | UniProt NCBI |
| STX5 | Syntaxin-5 | UniProt NCBI |
| NBAS | Neuroblastoma-amplified sequence (Neuroblastoma-amplified gene protein) | UniProt NCBI |
| STX18 | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | UniProt NCBI |
| CCDC107 | Coiled-coil domain-containing protein 107 | UniProt NCBI |
| SEC22B | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | UniProt NCBI |
| RINT1 | RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) | UniProt NCBI |
| BET1 | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | UniProt NCBI |
| C19orf25 | UPF0449 protein C19orf25 | UniProt NCBI |
| ZW10 | Centromere/kinetochore protein zw10 homolog | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04130 | 5.17828461206e-12 | 0.461538461538 | BET1 BNIP1 USE1 SEC22B STX5 STX18 | SNARE interactions in vesicular transport |
| GO:0006890 | 5.04840160599e-11 | 0.615384615385 | RINT1 SCFD1 USE1 NBAS SEC22B ZW10 STX18 BNIP1 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| REAC:R-HSA-6811434 | 1.47192416829e-10 | 0.538461538462 | RINT1 USE1 NBAS SEC22B ZW10 STX18 BNIP1 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6811442 | 2.36423269064e-10 | 0.615384615385 | ZW10 BNIP1 USE1 STX18 SEC22B STX5 NBAS RINT1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0048193 | 3.4626072073e-10 | 0.769230769231 | BET1 BNIP1 SCFD1 USE1 ZW10 STX18 SEC22B STX5 NBAS RINT1 | Golgi vesicle transport |
| REAC:R-HSA-199991 | 4.65681385989e-10 | 0.769230769231 | BET1 BNIP1 SCFD1 USE1 ZW10 STX18 SEC22B STX5 NBAS RINT1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 7.94451612348e-10 | 0.769230769231 | BET1 BNIP1 SCFD1 USE1 ZW10 STX18 SEC22B STX5 NBAS RINT1 | Vesicle-mediated transport |
| REAC:R-HSA-8856688 | 1.28889911947e-09 | 0.538461538462 | RINT1 USE1 NBAS SEC22B ZW10 STX18 BNIP1 | Golgi-to-ER retrograde transport |
| GO:0006888 | 3.03844513776e-06 | 0.538461538462 | BET1 RINT1 SCFD1 STX5 SEC22B ZW10 STX18 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0031201 | 1.4188694925e-05 | 0.384615384615 | STX5 STX18 SEC22B BNIP1 BET1 | SNARE complex |
| GO:0070939 | 2.59741127426e-05 | 0.230769230769 | ZW10 RINT1 NBAS | Dsl1/NZR complex |
| REAC:R-HSA-204005 | 4.23677548486e-05 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | COPII-mediated vesicle transport |
| CORUM:705 | 0.000120779759493 | 0.153846153846 | ZW10 RINT1 | SNARE complex (RINT1, ZW10, p31) |
| GO:0005484 | 0.000472044415433 | 0.307692307692 | STX5 SEC22B BNIP1 BET1 | SNAP receptor activity |
| REAC:R-HSA-199977 | 0.00133963029476 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | ER to Golgi Anterograde Transport |
| GO:0016192 | 0.00151512612056 | 0.769230769231 | BET1 BNIP1 SCFD1 USE1 ZW10 STX18 SEC22B STX5 NBAS RINT1 | vesicle-mediated transport |
| REAC:R-HSA-948021 | 0.0025265024376 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | Transport to the Golgi and subsequent modification |
| GO:0060628 | 0.0056884522543 | 0.230769230769 | SCFD1 RINT1 STX18 | regulation of ER to Golgi vesicle-mediated transport |
| GO:0048207 | 0.00827822507569 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | vesicle targeting, rough ER to cis-Golgi |
| GO:0048208 | 0.00827822507569 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | COPII vesicle coating |
| GO:0044432 | 0.00985318605173 | 0.615384615385 | ZW10 BNIP1 USE1 STX18 SEC22B STX5 NBAS RINT1 | endoplasmic reticulum part |
| GO:0006901 | 0.010765426249 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | vesicle coating |
| GO:0090114 | 0.0121996110402 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | COPII-coated vesicle budding |
| GO:0048199 | 0.0137717183687 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | vesicle targeting, to, from or within Golgi |
| GO:0048194 | 0.0183614143254 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | Golgi vesicle budding |
| REAC:R-HSA-446203 | 0.0195947027995 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | Asparagine N-linked glycosylation |
| GO:0090174 | 0.024004996189 | 0.307692307692 | STX5 SEC22B BNIP1 BET1 | organelle membrane fusion |
| GO:0006903 | 0.0323768018309 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | vesicle targeting |
| GO:0006900 | 0.0467039915804 | 0.307692307692 | STX5 SEC22B SCFD1 BET1 | vesicle budding from membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RINT1 | ZW10 | 1.0 | 0.949 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM hein (ZW10) gupta_WMM |
| BNIP1 | STX18 | 0.999 | 0.945 | hein_WMM bioplex (STX18) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NBAS | STX18 | 0.997 | 0.93 | hein_WMM bioplex (STX18) bioplex_WMM youn_WMM |
| STX18 | ZW10 | 0.995 | 0.924 | hein_WMM bioplex (STX18) bioplex_WMM boldt youn_WMM hein (ZW10) boldt_WMM |
| USE1 | ZW10 | 0.984 | 0.899 | hein_WMM bioplex (USE1) bioplex_WMM youn_WMM hein (ZW10) |
| USE1 | NBAS | 0.983 | 0.899 | hein_WMM bioplex (USE1) bioplex_WMM youn_WMM |
| STX5 | SCFD1 | 0.978 | 0.894 | hein_WMM bioplex (STX5) bioplex_WMM youn_WMM gupta_WMM |
| USE1 | SCFD2 | 0.88 | 0.813 | hein_WMM bioplex (SCFD2,USE1) bioplex_WMM youn_WMM |
| STX18 | SEC22B | 0.856 | 0.793 | bioplex (SEC22B,STX18) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SCFD2 | ZW10 | 0.849 | 0.79 | hein_WMM bioplex (SCFD2) bioplex_WMM youn_WMM hein (ZW10) |
| RINT1 | NBAS | 0.8 | 0.766 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM |
| SCFD2 | NBAS | 0.764 | 0.748 | hein_WMM bioplex (SCFD2) bioplex_WMM youn_WMM |
| C19orf25 | ZW10 | 0.7 | 0.722 | hein_WMM bioplex_WMM hein (ZW10) gupta_WMM |
| STX18 | SCFD1 | 0.663 | 0.698 | hein_WMM bioplex (STX18) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| USE1 | STX18 | 0.6 | 0.67 | hein_WMM bioplex (STX18,USE1) bioplex_WMM youn_WMM gupta_WMM |
| BET1 | STX18 | 0.574 | 0.656 | bioplex (STX18) bioplex_WMM youn_WMM gupta_WMM |
| RINT1 | C19orf25 | 0.559 | 0.65 | hein_WMM bioplex (RINT1) bioplex_WMM gupta_WMM |
| SCFD2 | RINT1 | 0.374 | 0.546 | hein_WMM bioplex (RINT1,SCFD2) bioplex_WMM youn_WMM |
| STX5 | SEC22B | 0.36 | 0.542 | hein_WMM bioplex (SEC22B) bioplex_WMM youn_WMM gupta_WMM |
| USE1 | RINT1 | 0.299 | 0.497 | hein_WMM bioplex (RINT1,USE1) bioplex_WMM youn_WMM |
| BNIP1 | SEC22B | 0.283 | 0.488 | bioplex (SEC22B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ZW10 | SCFD1 | 0.245 | 0.469 | hein_WMM bioplex_WMM youn_WMM hein (ZW10) gupta_WMM treiber_WMM |
| BNIP1 | ZW10 | 0.165 | 0.42 | hein_WMM bioplex_WMM youn_WMM hein (ZW10) |
| SEC22B | SCFD1 | 0.15 | 0.409 | hein_WMM bioplex (SEC22B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SCFD2 | BNIP1 | 0.116 | 0.389 | hein_WMM bioplex (SCFD2) bioplex_WMM youn_WMM |
| NBAS | ZW10 | 0.114 | 0.384 | hein_WMM bioplex_WMM youn_WMM hein (ZW10) |
| NBAS | SEC22B | 0.095 | 0.359 | bioplex (SEC22B) bioplex_WMM youn_WMM |
| STX5 | STX18 | 0.083 | 0.349 | bioplex (STX18) bioplex_WMM youn_WMM gupta_WMM |
| SCFD2 | C19orf25 | 0.08 | 0.35 | hein_WMM bioplex (SCFD2) bioplex_WMM |
| RINT1 | STX18 | 0.078 | 0.353 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM |
| SCFD2 | STX18 | 0.065 | 0.348 | hein_WMM bioplex (SCFD2) bioplex_WMM youn_WMM |
| BET1 | SEC22B | 0.06 | 0.336 | hein_WMM bioplex (SEC22B) bioplex_WMM youn_WMM gupta_WMM |
| USE1 | SCFD1 | 0.053 | 0.301 | hein_WMM bioplex (USE1) bioplex_WMM youn_WMM gupta_WMM |
| RINT1 | BNIP1 | 0.051 | 0.3 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM |
| STX18 | CCDC107 | 0.02 | 0.188 | bioplex (CCDC107) bioplex_WMM |
| USE1 | SEC22B | 0.02 | 0.187 | bioplex (SEC22B,USE1) bioplex_WMM youn_WMM gupta_WMM |
| USE1 | BNIP1 | 0.02 | 0.188 | hein_WMM bioplex (USE1) bioplex_WMM youn_WMM gupta_WMM |
| ZW10 | SEC22B | 0.019 | 0.187 | bioplex (SEC22B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SCFD2 | SEC22B | 0.018 | 0.177 | bioplex (SCFD2,SEC22B) bioplex_WMM youn_WMM |
| SCFD2 | SCFD1 | 0.017 | 0.173 | hein_WMM bioplex (SCFD2) bioplex_WMM youn_WMM |
| BNIP1 | SCFD1 | 0.016 | 0.161 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| BNIP1 | NBAS | 0.015 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RINT1 | SCFD1 | 0.015 | 0.14 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM |
| NBAS | SCFD1 | 0.014 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| BET1 | STX5 | 0.013 | 0.151 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| BNIP1 | CCDC107 | 0.012 | 0.144 | bioplex (CCDC107) bioplex_WMM |
| RINT1 | SEC22B | 0.011 | 0.142 | bioplex (RINT1,SEC22B) bioplex_WMM youn_WMM gupta_WMM |
| NBAS | C19orf25 | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| STX5 | BNIP1 | 0.01 | 0.121 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| STX5 | NBAS | 0.01 | 0.101 | bioplex_WMM youn_WMM WMM_only |
| BET1 | USE1 | 0.009 | 0.105 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| BET1 | NBAS | 0.009 | 0.09 | bioplex_WMM youn_WMM WMM_only |
| BET1 | BNIP1 | 0.008 | 0.068 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SCFD2 | STX5 | 0.008 | 0.063 | bioplex_WMM youn_WMM WMM_only |
| BNIP1 | C19orf25 | 0.008 | 0.031 | hein_WMM bioplex_WMM WMM_only |
| C19orf25 | SCFD1 | 0.008 | 0.023 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| C19orf25 | STX18 | 0.008 | 0.029 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| BET1 | ZW10 | 0.007 | 0.011 | bioplex_WMM youn_WMM WMM_only |
| BET1 | SCFD2 | 0.007 | 0.009 | bioplex_WMM youn_WMM WMM_only |
| C19orf25 | SEC22B | 0.007 | 0.007 | bioplex (SEC22B) bioplex_WMM gupta_WMM |
| CCDC107 | SEC22B | 0.007 | 0.005 | bioplex (CCDC107) bioplex_WMM |
| CCDC107 | SCFD1 | 0.007 | 0.005 | bioplex (CCDC107) bioplex_WMM |
| BET1 | RINT1 | 0.007 | 0.006 | bioplex_WMM youn_WMM WMM_only |
| BET1 | C19orf25 | 0.007 | 0.002 | bioplex_WMM gupta_WMM WMM_only |
| BET1 | SCFD1 | 0.007 | 0.004 | bioplex (BET1) bioplex_WMM youn_WMM gupta_WMM |
| STX5 | RINT1 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| STX5 | C19orf25 | 0.006 | 0.007 | bioplex_WMM gupta_WMM WMM_only |
| STX5 | ZW10 | 0.006 | 0.001 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| STX5 | CCDC107 | 0.005 | 0.012 | bioplex (CCDC107) bioplex_WMM |
| USE1 | C19orf25 | 0.0 | 0.014 | hein_WMM bioplex (USE1) bioplex_WMM |
| USE1 | STX5 | 0.0 | 0.007 | bioplex (USE1) bioplex_WMM youn_WMM gupta_WMM |
Images
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Complex HuMAP2_00854 has an average edge precision of 0.332 which is ranked 4212 out of all 6965 complexes.
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