hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00857
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| STK25 | Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) | UniProt NCBI |
| STK26 | Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK) | UniProt NCBI |
| PDCD10 | Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15) | UniProt NCBI |
| STK24 | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] | UniProt NCBI |
| C4orf19 | Uncharacterized protein C4orf19 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036473 | 3.84719751497e-05 | 0.8 | STK25 STK24 STK26 PDCD10 | cell death in response to oxidative stress |
| GO:0042542 | 5.53512234664e-05 | 0.8 | STK25 STK24 STK26 PDCD10 | response to hydrogen peroxide |
| GO:0036474 | 0.000616695699567 | 0.6 | STK25 STK26 PDCD10 | cell death in response to hydrogen peroxide |
| GO:0046677 | 0.000674764960334 | 0.8 | STK25 STK24 STK26 PDCD10 | response to antibiotic |
| GO:0000302 | 0.000838244988417 | 0.8 | STK25 STK24 STK26 PDCD10 | response to reactive oxygen species |
| GO:0009636 | 0.00318044625552 | 0.8 | STK25 STK24 STK26 PDCD10 | response to toxic substance |
| GO:0008631 | 0.0049400991777 | 0.6 | STK25 STK24 PDCD10 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| GO:0034599 | 0.00511048538005 | 0.8 | STK25 STK24 STK26 PDCD10 | cellular response to oxidative stress |
| REAC:R-HSA-111465 | 0.00894729002053 | 0.4 | STK24 STK26 | Apoptotic cleavage of cellular proteins |
| GO:0070301 | 0.0128326937391 | 0.6 | STK25 STK26 PDCD10 | cellular response to hydrogen peroxide |
| REAC:R-HSA-75153 | 0.0170965985867 | 0.4 | STK24 STK26 | Apoptotic execution phase |
| GO:0006979 | 0.0200611173853 | 0.8 | STK25 STK24 STK26 PDCD10 | response to oxidative stress |
| GO:0010035 | 0.0213635146551 | 0.8 | STK25 STK24 STK26 PDCD10 | response to inorganic substance |
| GO:0036481 | 0.0270421395626 | 0.4 | STK25 PDCD10 | intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
| GO:0090168 | 0.0270421395626 | 0.4 | STK25 PDCD10 | Golgi reassembly |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STK24 | STK25 | 1.0 | 0.949 | bioplex (STK25) bioplex_WMM |
| STK24 | PDCD10 | 1.0 | 0.949 | hein_WMM bioplex (PDCD10) bioplex_WMM Malo fraction |
| STK25 | STK26 | 1.0 | 0.949 | bioplex (STK25) bioplex_WMM |
| STK26 | PDCD10 | 1.0 | 0.949 | hein_WMM bioplex (PDCD10) bioplex_WMM Malo fraction |
| STK25 | PDCD10 | 0.999 | 0.949 | bioplex (PDCD10,STK25) bioplex_WMM Malo fraction |
| STK24 | C4orf19 | 0.929 | 0.845 | bioplex (C4orf19) bioplex_WMM |
| PDCD10 | C4orf19 | 0.561 | 0.65 | bioplex (C4orf19) bioplex_WMM |
| STK25 | C4orf19 | 0.083 | 0.35 | bioplex (C4orf19) bioplex_WMM |
| STK26 | C4orf19 | 0.081 | 0.351 | bioplex (C4orf19) bioplex_WMM |
| STK24 | STK26 | 0.022 | 0.2 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00857 has an average edge precision of 0.714 which is ranked 1327 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| STK25 | HuMAP2_00795 HuMAP2_00857 HuMAP2_01720 HuMAP2_04545 HuMAP2_06172 HuMAP2_06914 |
| STK26 | HuMAP2_00857 HuMAP2_01720 HuMAP2_06172 HuMAP2_06914 |
| PDCD10 | HuMAP2_00857 HuMAP2_01720 HuMAP2_06172 HuMAP2_06914 |
| STK24 | HuMAP2_00578 HuMAP2_00795 HuMAP2_00857 HuMAP2_03192 HuMAP2_06172 HuMAP2_06914 |
| C4orf19 | HuMAP2_00857 HuMAP2_03192 HuMAP2_06172 HuMAP2_06914 |