hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00862
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EXOC4 | Exocyst complex component 4 (Exocyst complex component Sec8) | UniProt NCBI |
| EXOC6B | Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) | UniProt NCBI |
| EXOC6 | Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) | UniProt NCBI |
| EXOC5 | Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) | UniProt NCBI |
| EXOC2 | Exocyst complex component 2 (Exocyst complex component Sec5) | UniProt NCBI |
| EXOC7 | Exocyst complex component 7 (Exocyst complex component Exo70) | UniProt NCBI |
| EXOC3 | Exocyst complex component 3 (Exocyst complex component Sec6) | UniProt NCBI |
| IL1R2 | Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)] | UniProt NCBI |
| EXOC8 | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6167 | 3.69393785629e-22 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Exocyst complex |
| CORUM:89 | 3.69393785629e-22 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Exocyst Sec6/8 complex |
| REAC:R-HSA-5620916 | 1.12015098305e-17 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | VxPx cargo-targeting to cilium |
| REAC:R-HSA-264876 | 7.68954386849e-17 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Insulin processing |
| GO:0000145 | 9.58179623688e-17 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC6B | exocyst |
| REAC:R-HSA-5620920 | 1.39350884541e-14 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Cargo trafficking to the periciliary membrane |
| REAC:R-HSA-1445148 | 2.14271888233e-13 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-2980736 | 2.38435744402e-13 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Peptide hormone metabolism |
| WP:WP4352 | 7.86262676362e-13 | 0.888888888889 | EXOC4 EXOC5 EXOC3 EXOC6B EXOC8 EXOC2 EXOC6 EXOC7 | Ciliary landscape |
| GO:0099023 | 1.28843990949e-11 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC6B | vesicle tethering complex |
| REAC:R-HSA-5617833 | 3.5860837084e-10 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Cilium Assembly |
| GO:0006893 | 4.37310078271e-09 | 0.666666666667 | EXOC4 EXOC5 EXOC6 EXOC8 EXOC2 EXOC6B | Golgi to plasma membrane transport |
| REAC:R-HSA-1852241 | 5.21697193233e-09 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Organelle biogenesis and maintenance |
| CORUM:6169 | 6.30476064954e-09 | 0.333333333333 | EXOC6 EXOC5 EXOC7 | Exocyst EXOC5-EXOC6-EXOC7 subcomplex |
| GO:0044448 | 8.46327249606e-09 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC6B | cell cortex part |
| GO:0098876 | 5.51743786788e-08 | 0.666666666667 | EXOC4 EXOC5 EXOC6 EXOC8 EXOC2 EXOC6B | vesicle-mediated transport to the plasma membrane |
| GO:0005938 | 1.16166877488e-07 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC6B | cell cortex |
| GO:0006892 | 2.08211146087e-07 | 0.666666666667 | EXOC4 EXOC5 EXOC6 EXOC8 EXOC2 EXOC6B | post-Golgi vesicle-mediated transport |
| REAC:R-HSA-199991 | 8.88804404405e-07 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 1.29101301448e-06 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Vesicle-mediated transport |
| GO:0099568 | 2.08212421895e-06 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC6B | cytoplasmic region |
| GO:0017160 | 3.06865717378e-06 | 0.444444444444 | EXOC8 EXOC2 EXOC4 EXOC5 | Ral GTPase binding |
| CORUM:6168 | 1.34129279418e-05 | 0.222222222222 | EXOC6 EXOC5 | Exocyst EXOC5-EXOC6 subcomplex |
| GO:0048193 | 0.00045729314833 | 0.666666666667 | EXOC4 EXOC5 EXOC6 EXOC8 EXOC2 EXOC6B | Golgi vesicle transport |
| WP:WP2290 | 0.00127880758353 | 0.222222222222 | EXOC8 EXOC2 | RalA downstream regulated genes |
| REAC:R-HSA-392499 | 0.0022131246723 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | Metabolism of proteins |
| WP:000000 | 0.00566194757866 | 1.0 | EXOC4 EXOC5 EXOC3 EXOC6B EXOC8 EXOC2 EXOC6 IL1R2 EXOC7 | WIKIPATHWAYS |
| CORUM:0000000 | 0.0319384059855 | 0.777777777778 | EXOC4 EXOC5 EXOC3 EXOC8 EXOC2 EXOC6 EXOC7 | CORUM root |
| GO:0006887 | 0.0409276649016 | 0.666666666667 | EXOC4 EXOC5 EXOC3 EXOC2 EXOC6 EXOC6B | exocytosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EXOC7 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6) bioplex_WMM boldt (EXOC6,EXOC7) Malo fraction boldt_WMM |
| EXOC8 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6,EXOC8) bioplex_WMM boldt (EXOC6,EXOC8) Malo fraction boldt_WMM |
| EXOC8 | EXOC7 | 1.0 | 0.949 | bioplex (EXOC8) bioplex_WMM boldt (EXOC8) Malo fraction boldt_WMM |
| EXOC4 | EXOC2 | 1.0 | 0.949 | bioplex_WMM boldt (EXOC2,EXOC4) youn_WMM Malo fraction boldt_WMM treiber_WMM |
| EXOC5 | EXOC6 | 1.0 | 0.949 | bioplex (EXOC6) bioplex_WMM boldt (EXOC5,EXOC6) Malo fraction boldt_WMM |
| EXOC8 | EXOC6B | 0.998 | 0.944 | bioplex (EXOC8) bioplex_WMM boldt (EXOC6B,EXOC8) Malo fraction boldt_WMM |
| EXOC4 | EXOC3 | 0.998 | 0.943 | bioplex (EXOC3) bioplex_WMM boldt (EXOC3,EXOC4) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EXOC7 | EXOC6B | 0.992 | 0.911 | bioplex_WMM boldt (EXOC6B,EXOC7) Malo fraction boldt_WMM |
| EXOC2 | EXOC3 | 0.99 | 0.909 | bioplex (EXOC3) bioplex_WMM boldt (EXOC2,EXOC3) Malo fraction boldt_WMM treiber_WMM |
| EXOC5 | EXOC7 | 0.979 | 0.895 | bioplex_WMM boldt (EXOC5,EXOC7) Malo fraction boldt_WMM |
| EXOC4 | EXOC7 | 0.959 | 0.865 | bioplex_WMM boldt (EXOC4,EXOC7) fraction boldt_WMM |
| EXOC4 | EXOC6 | 0.939 | 0.851 | bioplex (EXOC6) bioplex_WMM boldt (EXOC4,EXOC6) youn_WMM fraction boldt_WMM |
| EXOC7 | EXOC3 | 0.763 | 0.749 | bioplex (EXOC3) bioplex_WMM boldt (EXOC3) fraction boldt_WMM |
| EXOC8 | EXOC5 | 0.708 | 0.729 | bioplex (EXOC8) bioplex_WMM boldt (EXOC5,EXOC8) Malo fraction boldt_WMM |
| EXOC2 | EXOC6B | 0.685 | 0.712 | bioplex_WMM boldt (EXOC6B) fraction boldt_WMM |
| EXOC5 | EXOC6B | 0.653 | 0.69 | bioplex_WMM boldt (EXOC5,EXOC6B) Malo fraction boldt_WMM |
| IL1R2 | EXOC6B | 0.603 | 0.671 | bioplex (IL1R2) bioplex_WMM |
| EXOC4 | EXOC5 | 0.385 | 0.551 | bioplex_WMM boldt (EXOC4,EXOC5) youn_WMM gupta_WMM fraction boldt_WMM |
| EXOC8 | EXOC4 | 0.256 | 0.479 | bioplex (EXOC8) bioplex_WMM boldt (EXOC4,EXOC8) fraction boldt_WMM |
| EXOC2 | EXOC7 | 0.232 | 0.47 | bioplex_WMM boldt fraction boldt_WMM |
| EXOC4 | EXOC6B | 0.166 | 0.422 | bioplex_WMM boldt (EXOC4,EXOC6B) fraction boldt_WMM |
| EXOC8 | EXOC3 | 0.15 | 0.41 | bioplex (EXOC3,EXOC8) bioplex_WMM boldt fraction boldt_WMM |
| EXOC2 | EXOC6 | 0.128 | 0.398 | bioplex (EXOC6) bioplex_WMM boldt (EXOC6) fraction boldt_WMM |
| IL1R2 | EXOC6 | 0.119 | 0.392 | bioplex (IL1R2) bioplex_WMM |
| EXOC3 | EXOC6 | 0.077 | 0.352 | bioplex (EXOC3,EXOC6) bioplex_WMM boldt fraction boldt_WMM |
| EXOC3 | EXOC6B | 0.056 | 0.312 | bioplex (EXOC3) bioplex_WMM boldt fraction boldt_WMM |
| EXOC5 | IL1R2 | 0.036 | 0.266 | bioplex (IL1R2) bioplex_WMM |
| IL1R2 | EXOC7 | 0.027 | 0.225 | bioplex (IL1R2) bioplex_WMM |
| EXOC8 | EXOC2 | 0.021 | 0.187 | bioplex (EXOC8) bioplex_WMM boldt fraction boldt_WMM |
| EXOC5 | EXOC3 | 0.02 | 0.186 | bioplex (EXOC3) bioplex_WMM boldt (EXOC5) fraction boldt_WMM |
| EXOC5 | EXOC2 | 0.018 | 0.178 | bioplex_WMM boldt (EXOC5) fraction boldt_WMM |
| EXOC6B | EXOC6 | 0.017 | 0.173 | bioplex_WMM boldt boldt_WMM |
| EXOC8 | IL1R2 | 0.012 | 0.147 | bioplex (IL1R2) bioplex_WMM |
| EXOC2 | IL1R2 | 0.011 | 0.135 | bioplex (IL1R2) bioplex_WMM |
| IL1R2 | EXOC3 | 0.01 | 0.122 | bioplex (IL1R2) bioplex_WMM |
| EXOC4 | IL1R2 | 0.007 | 0.004 | bioplex (IL1R2) bioplex_WMM |
Images
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Complex HuMAP2_00862 has an average edge precision of 0.556 which is ranked 2158 out of all 6965 complexes.
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