hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00866
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KLHL42 | Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5) | UniProt NCBI |
| CUL3 | Cullin-3 (CUL-3) | UniProt NCBI |
| KCTD20 | BTB/POZ domain-containing protein KCTD20 (Potassium channel tetramerization domain containing 20) | UniProt NCBI |
| KLHL8 | Kelch-like protein 8 | UniProt NCBI |
| KBTBD6 | Kelch repeat and BTB domain-containing protein 6 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7518 | 6.70868171695e-06 | 0.4 | CUL3 KLHL8 | Ubiquitin E3 ligase (CUL3, KLHL8) |
| CORUM:7533 | 6.70868171695e-06 | 0.4 | CUL3 KLHL42 | Ubiquitin E3 ligase (CUL3, KLHL42) |
| REAC:R-HSA-8951664 | 0.00478425526644 | 0.6 | CUL3 KBTBD6 KLHL42 | Neddylation |
| GO:0031463 | 0.00703245670927 | 0.6 | CUL3 KLHL42 KLHL8 | Cul3-RING ubiquitin ligase complex |
| REAC:R-HSA-983168 | 0.0108447834234 | 0.6 | CUL3 KBTBD6 KLHL42 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-983169 | 0.0184395275066 | 0.6 | CUL3 KBTBD6 KLHL42 | Class I MHC mediated antigen processing & presentation |
| MIRNA:hsa-miR-519b-3p | 0.0271629642101 | 0.6 | CUL3 KBTBD6 KLHL8 | hsa-miR-519b-3p |
| MIRNA:hsa-miR-519a-3p | 0.0284753654038 | 0.6 | CUL3 KBTBD6 KLHL8 | hsa-miR-519a-3p |
| MIRNA:hsa-miR-519c-3p | 0.0284753654038 | 0.6 | CUL3 KBTBD6 KLHL8 | hsa-miR-519c-3p |
| CORUM:6267 | 0.0499494897235 | 0.2 | CUL3 | Ubiquitin E3 ligase (CUL3, KLHL3) |
| CORUM:6815 | 0.0499494897235 | 0.2 | CUL3 | DRD4-KLHL12-CUL3 complex |
| CORUM:7370 | 0.0499494897235 | 0.2 | CUL3 | CUL3-KCTD11 complex |
| CORUM:7371 | 0.0499494897235 | 0.2 | CUL3 | CUL3-KCTD6 complex |
| CORUM:7526 | 0.0499494897235 | 0.2 | CUL3 | Ubiquitin E3 ligase (CUL3, KLHL25) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CUL3 | KLHL42 | 0.979 | 0.896 | hein_WMM bioplex (CUL3) bioplex_WMM hein (CUL3) |
| KBTBD6 | CUL3 | 0.804 | 0.768 | hein_WMM bioplex (CUL3) bioplex_WMM boldt youn_WMM hein (CUL3) boldt_WMM |
| CUL3 | KLHL8 | 0.591 | 0.664 | hein_WMM bioplex (CUL3) bioplex_WMM hein (CUL3) |
| CUL3 | KCTD20 | 0.571 | 0.655 | hein_WMM bioplex (CUL3) bioplex_WMM hein (CUL3) |
| KCTD20 | KLHL42 | 0.008 | 0.083 | hein_WMM bioplex_WMM WMM_only |
| KCTD20 | KLHL8 | 0.008 | 0.082 | hein_WMM bioplex_WMM WMM_only |
| KBTBD6 | KCTD20 | 0.008 | 0.037 | hein_WMM bioplex_WMM WMM_only |
| KLHL42 | KLHL8 | 0.008 | 0.027 | hein_WMM bioplex_WMM WMM_only |
| KBTBD6 | KLHL8 | 0.007 | 0.009 | hein_WMM bioplex_WMM WMM_only |
| KBTBD6 | KLHL42 | 0.006 | 0.004 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00866 has an average edge precision of 0.323 which is ranked 4311 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KLHL42 | HuMAP2_00866 HuMAP2_03890 HuMAP2_05391 HuMAP2_05454 HuMAP2_05548 HuMAP2_06858 |
| CUL3 | HuMAP2_00866 HuMAP2_03890 HuMAP2_05391 HuMAP2_05647 |
| KCTD20 | HuMAP2_00866 HuMAP2_03465 HuMAP2_03890 HuMAP2_05859 |
| KLHL8 | HuMAP2_00866 HuMAP2_01368 HuMAP2_03890 HuMAP2_05647 |
| KBTBD6 | HuMAP2_00866 HuMAP2_01025 HuMAP2_01891 HuMAP2_03890 HuMAP2_05857 HuMAP2_06041 |