hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00873
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) | UniProt NCBI |
| CHORDC1 | Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana) | UniProt NCBI |
| BLVRB | Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) | UniProt NCBI |
| CRIP2 | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | UniProt NCBI |
| RAC3 | Ras-related C3 botulinum toxin substrate 3 (p21-Rac3) | UniProt NCBI |
| RAC2 | Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2290 | 3.29800460256e-07 | 0.5 | RAC3 RAC1 RAC2 | RalA downstream regulated genes |
| WP:WP3937 | 6.06977286255e-06 | 0.5 | RAC3 RAC1 RAC2 | Microglia Pathogen Phagocytosis Pathway |
| KEGG:05416 | 2.5364610263e-05 | 0.5 | RAC3 RAC1 RAC2 | Viral myocarditis |
| KEGG:04370 | 4.37769643831e-05 | 0.5 | RAC3 RAC1 RAC2 | VEGF signaling pathway |
| KEGG:04664 | 4.37769643831e-05 | 0.5 | RAC3 RAC1 RAC2 | Fc epsilon RI signaling pathway |
| KEGG:04662 | 7.9791370908e-05 | 0.5 | RAC3 RAC1 RAC2 | B cell receptor signaling pathway |
| WP:WP4216 | 8.49189157531e-05 | 0.5 | RAC3 RAC1 RAC2 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:04520 | 8.72418800052e-05 | 0.5 | RAC3 RAC1 RAC2 | Adherens junction |
| KEGG:05212 | 9.51406370938e-05 | 0.5 | RAC3 RAC1 RAC2 | Pancreatic cancer |
| WP:WP4263 | 0.000136265489266 | 0.5 | RAC3 RAC1 RAC2 | Pancreatic adenocarcinoma pathway |
| KEGG:05210 | 0.000147172017102 | 0.5 | RAC3 RAC1 RAC2 | Colorectal cancer |
| KEGG:05231 | 0.000188524277315 | 0.5 | RAC3 RAC1 RAC2 | Choline metabolism in cancer |
| WP:WP185 | 0.000192159737634 | 0.5 | RAC3 RAC1 RAC2 | Integrin-mediated Cell Adhesion |
| KEGG:04650 | 0.000259985721773 | 0.5 | RAC3 RAC1 RAC2 | Natural killer cell mediated cytotoxicity |
| WP:WP710 | 0.000269213029719 | 0.5 | RAC3 RAC1 RAC2 | DNA Damage Response (only ATM dependent) |
| KEGG:04071 | 0.000347449247485 | 0.5 | RAC3 RAC1 RAC2 | Sphingolipid signaling pathway |
| KEGG:05135 | 0.000377045038279 | 0.5 | RAC3 RAC1 RAC2 | Yersinia infection |
| KEGG:05418 | 0.000524612840052 | 0.5 | RAC3 RAC1 RAC2 | Fluid shear stress and atherosclerosis |
| WP:WP51 | 0.000551527499474 | 0.5 | RAC3 RAC1 RAC2 | Regulation of Actin Cytoskeleton |
| KEGG:04062 | 0.000590221771159 | 0.5 | RAC3 RAC1 RAC2 | Chemokine signaling pathway |
| REAC:R-HSA-4086400 | 0.000713906652255 | 0.5 | RAC3 RAC1 RAC2 | PCP/CE pathway |
| KEGG:04310 | 0.000853469762609 | 0.5 | RAC3 RAC1 RAC2 | Wnt signaling pathway |
| WP:WP4223 | 0.000892901960021 | 0.5 | RAC3 RAC1 RAC2 | Ras Signaling |
| KEGG:04360 | 0.00120635789569 | 0.5 | RAC3 RAC1 RAC2 | Axon guidance |
| KEGG:04024 | 0.00131909231464 | 0.5 | RAC3 RAC1 RAC2 | cAMP signaling pathway |
| KEGG:04015 | 0.0013899609933 | 0.5 | RAC3 RAC1 RAC2 | Rap1 signaling pathway |
| WP:WP306 | 0.00159070884596 | 0.5 | RAC3 RAC1 RAC2 | Focal Adhesion |
| KEGG:04014 | 0.0016712630824 | 0.5 | RAC3 RAC1 RAC2 | Ras signaling pathway |
| KEGG:04810 | 0.00175401113695 | 0.5 | RAC3 RAC1 RAC2 | Regulation of actin cytoskeleton |
| KEGG:04510 | 0.00181065209593 | 0.5 | RAC3 RAC1 RAC2 | Focal adhesion |
| KEGG:05170 | 0.00211201253822 | 0.5 | RAC3 RAC1 RAC2 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-194840 | 0.00213862419482 | 0.5 | RAC3 RAC1 RAC2 | Rho GTPase cycle |
| KEGG:05163 | 0.00220846662002 | 0.5 | RAC3 RAC1 RAC2 | Human cytomegalovirus infection |
| REAC:R-HSA-3858494 | 0.00244639935002 | 0.5 | RAC3 RAC1 RAC2 | Beta-catenin independent WNT signaling |
| WP:WP382 | 0.00250833969364 | 0.5 | RAC3 RAC1 RAC2 | MAPK Signaling Pathway |
| REAC:R-HSA-5668599 | 0.00377982352449 | 0.333333333333 | RAC2 RAC1 | RHO GTPases Activate NADPH Oxidases |
| KEGG:04010 | 0.0044724791401 | 0.5 | RAC3 RAC1 RAC2 | MAPK signaling pathway |
| REAC:R-HSA-114604 | 0.00834193552282 | 0.333333333333 | RAC2 RAC1 | GPVI-mediated activation cascade |
| WP:WP4298 | 0.0153070697985 | 0.333333333333 | RAC3 RAC2 | Viral Acute Myocarditis |
| WP:WP23 | 0.021066272601 | 0.333333333333 | RAC2 RAC1 | B Cell Receptor Signaling Pathway |
| REAC:R-HSA-2219530 | 0.0217814503669 | 0.333333333333 | RAC2 RAC1 | Constitutive Signaling by Aberrant PI3K in Cancer |
| KEGG:04670 | 0.0236020276363 | 0.333333333333 | RAC2 RAC1 | Leukocyte transendothelial migration |
| KEGG:04666 | 0.0236020276363 | 0.333333333333 | RAC2 RAC1 | Fc gamma R-mediated phagocytosis |
| KEGG:05200 | 0.0260948095216 | 0.5 | RAC3 RAC1 RAC2 | Pathways in cancer |
| REAC:R-HSA-195721 | 0.0279474259382 | 0.5 | RAC3 RAC1 RAC2 | Signaling by WNT |
| WP:WP3929 | 0.0416969783243 | 0.333333333333 | RAC2 RAC1 | Chemokine signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAC3 | RAC2 | 0.94 | 0.852 | bioplex (RAC2) bioplex_WMM |
| RAC3 | RAC1 | 0.171 | 0.43 | bioplex (RAC1) bioplex_WMM |
| CRIP2 | RAC1 | 0.11 | 0.379 | fraction |
| CHORDC1 | RAC1 | 0.094 | 0.357 | bioplex_WMM gupta_WMM fraction |
| BLVRB | RAC1 | 0.071 | 0.351 | bioplex_WMM fraction treiber_WMM |
| CHORDC1 | BLVRB | 0.06 | 0.335 | bioplex_WMM fraction |
| CHORDC1 | RAC2 | 0.006 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| BLVRB | CRIP2 | 0.003 | 0.013 | fraction |
| CHORDC1 | CRIP2 | 0.003 | 0.014 | fraction |
Images
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Complex HuMAP2_00873 has an average edge precision of 0.304 which is ranked 4524 out of all 6965 complexes.
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