hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00874
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DSCC1 | Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog) | UniProt NCBI |
| ATAD5 | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | UniProt NCBI |
| RFC1 | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | UniProt NCBI |
| RAD17 | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) | UniProt NCBI |
| CHTF8 | Chromosome transmission fidelity protein 8 homolog (hCTF8) | UniProt NCBI |
| RFC2 | Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) | UniProt NCBI |
| RFC3 | Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) | UniProt NCBI |
| RFC4 | Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) | UniProt NCBI |
| RFC5 | Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0003689 | 4.46966480611e-19 | 0.777777777778 | CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 | DNA clamp loader activity |
| GO:0033170 | 4.46966480611e-19 | 0.777777777778 | CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 | protein-DNA loading ATPase activity |
| CORUM:2804 | 1.60394245013e-18 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | CTF18-cohesion-RFC complex |
| CORUM:3070 | 6.41466161917e-18 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | CTF18-cohesion-RFC-POLH complex |
| CORUM:279 | 8.53043734036e-16 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | RFC complex |
| CORUM:2810 | 8.53043734036e-16 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | RAD17-RFC complex |
| CORUM:277 | 8.53043734036e-16 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | RFC complex |
| CORUM:2799 | 8.53043734036e-16 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | RFC complex |
| CORUM:270 | 8.53043734036e-16 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | RAD17-RFC complex |
| CORUM:266 | 8.53043734036e-16 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | RAD17-RFC complex |
| GO:1900264 | 1.94077036466e-15 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | positive regulation of DNA-directed DNA polymerase activity |
| GO:1900262 | 1.94077036466e-15 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | regulation of DNA-directed DNA polymerase activity |
| CORUM:2203 | 5.11711653312e-15 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | BRD4-RFC complex |
| GO:0031390 | 7.76174055919e-15 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | Ctf18 RFC-like complex |
| CORUM:268 | 4.77383702568e-14 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | 9-1-1-RAD17-RFC complex |
| CORUM:274 | 4.77383702568e-14 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | 9-1-1-RAD17-RFC complex |
| CORUM:1003 | 1.07387282252e-13 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | RC complex (Replication competent complex) |
| GO:0006275 | 1.7527694586e-13 | 0.888888888889 | CHTF8 RAD17 RFC4 DSCC1 RFC2 ATAD5 RFC5 RFC3 | regulation of DNA replication |
| GO:0006260 | 8.49720650772e-13 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | DNA replication |
| GO:0042623 | 9.69051340508e-13 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | ATPase activity, coupled |
| GO:0005663 | 1.03218291818e-12 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | DNA replication factor C complex |
| CORUM:2200 | 2.54036423996e-12 | 0.444444444444 | RFC2 RFC5 RFC3 RFC4 | RFC2-5 subcomplex |
| GO:0017116 | 3.42535836404e-12 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | single-stranded DNA helicase activity |
| REAC:R-HSA-174411 | 8.21621277453e-12 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69091 | 8.21621277453e-12 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Polymerase switching |
| REAC:R-HSA-69109 | 8.21621277453e-12 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Leading Strand Synthesis |
| CORUM:2201 | 1.26984090249e-11 | 0.444444444444 | RFC2 RFC5 RFC3 RFC4 | PCNA-RFC2-5 complex |
| CORUM:2202 | 1.26984090249e-11 | 0.444444444444 | RFC2 RFC5 RFC3 RFC4 | CHTF18-RFC2-5 complex |
| CORUM:2199 | 1.26984090249e-11 | 0.444444444444 | RFC2 RFC5 RFC3 RFC4 | CHTF18-RFC2-5 complex |
| REAC:R-HSA-110312 | 1.79182527793e-11 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Translesion synthesis by REV1 |
| REAC:R-HSA-5655862 | 2.53785052515e-11 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Translesion synthesis by POLK |
| REAC:R-HSA-5656121 | 2.53785052515e-11 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Translesion synthesis by POLI |
| KEGG:03430 | 3.54065147848e-11 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Mismatch repair |
| GO:0016887 | 3.67313967966e-11 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | ATPase activity |
| CORUM:2797 | 3.80849928415e-11 | 0.444444444444 | RFC2 RFC5 RFC3 RFC4 | PCNA-CHL12-RFC2-5 complex |
| REAC:R-HSA-110320 | 4.76679145774e-11 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Translesion Synthesis by POLH |
| REAC:R-HSA-69186 | 6.35429801147e-11 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 8.33814755212e-11 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | PCNA-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-5685942 | 9.03271825157e-11 | 0.666666666667 | RFC1 RAD17 RFC4 RFC2 RFC3 RFC5 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-174417 | 1.74046114569e-10 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-5696397 | 2.17508889246e-10 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110373 | 2.17508889246e-10 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03030 | 3.9552821904e-10 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | DNA replication |
| GO:0008094 | 4.84637842227e-10 | 0.777777777778 | CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 | DNA-dependent ATPase activity |
| REAC:R-HSA-180786 | 5.82751762167e-10 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Extension of Telomeres |
| REAC:R-HSA-110314 | 5.82751762167e-10 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-5656169 | 6.946636541e-10 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 8.23120505363e-10 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | DNA strand elongation |
| GO:0090329 | 8.99580995724e-10 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | regulation of DNA-dependent DNA replication |
| WP:WP466 | 1.04286737299e-09 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | DNA Replication |
| KEGG:03420 | 1.13736292209e-09 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Nucleotide excision repair |
| REAC:R-HSA-73933 | 1.32603473019e-09 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-5685938 | 1.53956601595e-09 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 1.77972404082e-09 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | Activation of ATR in response to replication stress |
| REAC:R-HSA-5693616 | 2.04891963335e-09 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-110313 | 2.04891963335e-09 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5693579 | 3.05697359708e-09 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-5696400 | 3.05697359708e-09 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Dual Incision in GG-NER |
| GO:0006261 | 4.9228198912e-09 | 0.777777777778 | RFC1 CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | DNA-dependent DNA replication |
| REAC:R-HSA-73893 | 6.24888675621e-09 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | DNA Damage Bypass |
| CORUM:278 | 6.30476064954e-09 | 0.333333333333 | RFC2 RFC4 RFC5 | RFC core complex |
| REAC:R-HSA-5693567 | 6.44819862896e-09 | 0.666666666667 | RFC1 RAD17 RFC4 RFC2 RFC3 RFC5 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 8.48852386103e-09 | 0.666666666667 | RFC1 RAD17 RFC4 RFC2 RFC3 RFC5 | Homology Directed Repair |
| GO:0017111 | 9.10840264264e-09 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | nucleoside-triphosphatase activity |
| GO:0003678 | 9.97438257457e-09 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | DNA helicase activity |
| GO:2000573 | 9.97438257457e-09 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | positive regulation of DNA biosynthetic process |
| GO:0071897 | 1.14926637561e-08 | 0.777777777778 | RFC1 CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | DNA biosynthetic process |
| GO:0070987 | 1.59492880088e-08 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | error-free translesion synthesis |
| GO:0042276 | 1.59492880088e-08 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | error-prone translesion synthesis |
| GO:0016462 | 1.67357737581e-08 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | pyrophosphatase activity |
| GO:0016817 | 1.72344950432e-08 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | hydrolase activity, acting on acid anhydrides |
| GO:0016818 | 1.72344950432e-08 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| CORUM:613 | 2.52114215054e-08 | 0.333333333333 | CHTF8 DSCC1 RFC3 | CTF18-CTF8-DCC1-RFC3 complex |
| REAC:R-HSA-5693532 | 2.6480735653e-08 | 0.666666666667 | RFC1 RAD17 RFC4 RFC2 RFC3 RFC5 | DNA Double-Strand Break Repair |
| REAC:R-HSA-6782210 | 3.09420649412e-08 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 3.35130430877e-08 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Dual incision in TC-NER |
| GO:0006297 | 3.45921649447e-08 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | nucleotide-excision repair, DNA gap filling |
| WP:WP2363 | 5.47101420889e-08 | 0.444444444444 | RFC4 RAD17 DSCC1 RFC3 | Gastric Cancer Network 2 |
| GO:0032201 | 8.29184516585e-08 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-6781827 | 8.54047366435e-08 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 1.03582085411e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Telomere Maintenance |
| REAC:R-HSA-5696399 | 1.2472416002e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| CORUM:435 | 1.25980927307e-07 | 0.333333333333 | RFC2 RFC1 RFC4 | BASC (Ab 81) complex (BRCA1-associated genome surveillance complex) |
| GO:2000278 | 1.48159713586e-07 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | regulation of DNA biosynthetic process |
| REAC:R-HSA-73884 | 1.49178226489e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Base Excision Repair |
| GO:0004386 | 1.70158852211e-07 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | helicase activity |
| REAC:R-HSA-6804756 | 1.87584364163e-07 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69473 | 2.21263770569e-07 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 2.59604420117e-07 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | Processing of DNA double-strand break ends |
| CORUM:434 | 3.52533406442e-07 | 0.333333333333 | RFC2 RFC1 RFC4 | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) |
| GO:0042769 | 3.86431070002e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | DNA damage response, detection of DNA damage |
| GO:0006296 | 4.46710734245e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| REAC:R-HSA-73886 | 4.47915167568e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Chromosome Maintenance |
| REAC:R-HSA-5696398 | 4.91582935183e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Nucleotide Excision Repair |
| GO:0033683 | 5.89775776057e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | nucleotide-excision repair, DNA incision |
| GO:0019985 | 6.73878294428e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | translesion synthesis |
| REAC:R-HSA-69239 | 7.01472264759e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Synthesis of DNA |
| REAC:R-HSA-69306 | 9.77386993847e-07 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | DNA Replication |
| CORUM:433 | 1.38327895355e-06 | 0.333333333333 | RFC2 RFC1 RFC4 | BASC complex (BRCA1-associated genome surveillance complex) |
| GO:0000731 | 1.40192652539e-06 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | DNA synthesis involved in DNA repair |
| REAC:R-HSA-73894 | 1.51609607484e-06 | 0.666666666667 | RFC1 RAD17 RFC4 RFC2 RFC3 RFC5 | DNA Repair |
| GO:0006301 | 2.16499893849e-06 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | postreplication repair |
| GO:0033260 | 2.65448688257e-06 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | nuclear DNA replication |
| REAC:R-HSA-5633007 | 2.96231961548e-06 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | Regulation of TP53 Activity |
| REAC:R-HSA-69242 | 3.15702459497e-06 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | S Phase |
| GO:0044786 | 3.89792521984e-06 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | cell cycle DNA replication |
| REAC:R-HSA-69481 | 4.04039220451e-06 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | G2/M Checkpoints |
| GO:0051054 | 4.19082204754e-06 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | positive regulation of DNA metabolic process |
| GO:0031391 | 7.62876038594e-06 | 0.333333333333 | ATAD5 RFC1 RFC4 | Elg1 RFC-like complex |
| GO:0005657 | 7.76645830023e-06 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | replication fork |
| GO:0044427 | 8.25928335505e-06 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | chromosomal part |
| GO:0140097 | 9.85118609503e-06 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | catalytic activity, acting on DNA |
| GO:0003677 | 1.10443747554e-05 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | DNA binding |
| GO:0006259 | 1.11971369405e-05 | 0.888888888889 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 | DNA metabolic process |
| GO:0005694 | 1.14454611104e-05 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | chromosome |
| CORUM:2805 | 1.34129279418e-05 | 0.222222222222 | CHTF8 DSCC1 | CTF8-DCC1 subcomplex |
| GO:0006283 | 1.52690691017e-05 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | transcription-coupled nucleotide-excision repair |
| CORUM:2806 | 4.02261743042e-05 | 0.222222222222 | CHTF8 DSCC1 | CTF18-CTF8-DCC1 complex |
| CORUM:612 | 4.02261743042e-05 | 0.222222222222 | CHTF8 DSCC1 | CTF18-CTF8-DCC1 complex |
| REAC:R-HSA-69620 | 6.04614679765e-05 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | Cell Cycle Checkpoints |
| REAC:R-HSA-1640170 | 7.49207314556e-05 | 0.666666666667 | RFC1 RAD17 RFC4 RFC2 RFC3 RFC5 | Cell Cycle |
| GO:0006289 | 9.74558912974e-05 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | nucleotide-excision repair |
| GO:0051052 | 0.00011507797834 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | regulation of DNA metabolic process |
| REAC:R-HSA-3700989 | 0.000157259098136 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | Transcriptional Regulation by TP53 |
| GO:0016787 | 0.000241822208307 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | hydrolase activity |
| GO:0090305 | 0.000265639912907 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | nucleic acid phosphodiester bond hydrolysis |
| GO:0022402 | 0.000350731570528 | 0.888888888889 | RFC1 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | cell cycle process |
| GO:0000723 | 0.000591061729231 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | telomere maintenance |
| GO:0051606 | 0.000653008727263 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | detection of stimulus |
| GO:1901796 | 0.000843811072913 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | regulation of signal transduction by p53 class mediator |
| GO:0032200 | 0.00089783193896 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | telomere organization |
| WP:WP2446 | 0.000944085934861 | 0.333333333333 | RFC5 RFC3 RFC4 | Retinoblastoma Gene in Cancer |
| CORUM:1004 | 0.00104260750106 | 0.222222222222 | RFC2 RFC1 | RC complex during S-phase of cell cycle |
| CORUM:1005 | 0.00104260750106 | 0.222222222222 | RFC2 RFC1 | RC complex during G2/M-phase of cell cycle |
| REAC:R-HSA-69278 | 0.00109486590053 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | Cell Cycle, Mitotic |
| GO:0007049 | 0.00137165375775 | 0.888888888889 | RFC1 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | cell cycle |
| CORUM:0000000 | 0.00227951320903 | 0.888888888889 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 | CORUM root |
| GO:0051347 | 0.00286178397492 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | positive regulation of transferase activity |
| GO:0006281 | 0.00305637044825 | 0.666666666667 | RFC1 RAD17 RFC4 RFC2 RFC3 RFC5 | DNA repair |
| GO:0072331 | 0.00514763506393 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | signal transduction by p53 class mediator |
| GO:0003676 | 0.00573616288407 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | nucleic acid binding |
| GO:0060249 | 0.0139062660017 | 0.555555555556 | RFC2 RFC4 RFC3 RFC5 RFC1 | anatomical structure homeostasis |
| GO:0061860 | 0.0162296428096 | 0.222222222222 | RFC1 ATAD5 | DNA clamp unloader activity |
| GO:0090618 | 0.0162296428096 | 0.222222222222 | RFC1 ATAD5 | DNA clamp unloading |
| GO:0051338 | 0.0295168127297 | 0.666666666667 | CHTF8 RFC4 DSCC1 RFC2 RFC3 RFC5 | regulation of transferase activity |
| REAC:R-HSA-212436 | 0.031660931122 | 0.555555555556 | RFC2 RFC5 RAD17 RFC3 RFC4 | Generic Transcription Pathway |
| WP:WP707 | 0.0421076132887 | 0.222222222222 | RAD17 RFC1 | DNA Damage Response |
| GO:1901363 | 0.0421918901553 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | heterocyclic compound binding |
| GO:0006974 | 0.043381774475 | 0.666666666667 | RFC1 RAD17 RFC4 RFC2 RFC3 RFC5 | cellular response to DNA damage stimulus |
| WP:WP1530 | 0.0459494563798 | 0.222222222222 | RAD17 RFC1 | miRNA Regulation of DNA Damage Response |
| GO:0010557 | 0.0479540615773 | 0.777777777778 | CHTF8 RFC4 DSCC1 RFC2 ATAD5 RFC5 RFC3 | positive regulation of macromolecule biosynthetic process |
| GO:0097159 | 0.0493093140851 | 1.0 | RFC1 CHTF8 RAD17 RFC4 DSCC1 RFC2 RFC3 RFC5 ATAD5 | organic cyclic compound binding |
| CORUM:1132 | 0.0499262710315 | 0.111111111111 | RFC4 | RFC2-RIalpha complex |
| CORUM:1131 | 0.0499262710315 | 0.111111111111 | RFC2 | RFC2-RIalpha complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RFC3 | RFC5 | 1.0 | 0.949 | hein_WMM bioplex (RFC5) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| RFC2 | RFC4 | 1.0 | 0.949 | hein_WMM bioplex (RFC4) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RFC5 | RFC4 | 1.0 | 0.949 | hein_WMM bioplex (RFC4,RFC5) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction treiber_WMM |
| RFC3 | RFC4 | 1.0 | 0.949 | hein_WMM bioplex (RFC4) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RFC2 | RFC3 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RFC2 | RFC5 | 0.999 | 0.948 | hein_WMM bioplex (RFC5) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DSCC1 | CHTF8 | 0.991 | 0.91 | bioplex (DSCC1) bioplex_WMM |
| RFC1 | RFC5 | 0.988 | 0.901 | hein_WMM bioplex (RFC5) bioplex_WMM Guru youn_WMM fraction |
| RFC3 | RFC1 | 0.936 | 0.85 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| RFC4 | ATAD5 | 0.894 | 0.819 | hein_WMM bioplex (RFC4) bioplex_WMM youn_WMM gupta_WMM |
| DSCC1 | RFC4 | 0.846 | 0.789 | bioplex (DSCC1,RFC4) bioplex_WMM |
| RFC1 | RFC4 | 0.619 | 0.675 | hein_WMM bioplex (RFC4) bioplex_WMM Guru youn_WMM fraction |
| RFC5 | DSCC1 | 0.582 | 0.663 | bioplex (DSCC1,RFC5) bioplex_WMM |
| RFC3 | DSCC1 | 0.452 | 0.595 | bioplex (DSCC1) bioplex_WMM |
| RFC2 | DSCC1 | 0.444 | 0.588 | bioplex (DSCC1) bioplex_WMM |
| RFC4 | RAD17 | 0.239 | 0.47 | bioplex (RAD17,RFC4) bioplex_WMM youn_WMM |
| RFC4 | CHTF8 | 0.134 | 0.405 | bioplex (RFC4) bioplex_WMM |
| RFC5 | ATAD5 | 0.133 | 0.406 | hein_WMM bioplex (RFC5) bioplex_WMM youn_WMM |
| RFC2 | RFC1 | 0.098 | 0.357 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| RFC5 | RAD17 | 0.059 | 0.328 | bioplex (RAD17,RFC5) bioplex_WMM youn_WMM |
| RFC5 | CHTF8 | 0.049 | 0.294 | bioplex (RFC5) bioplex_WMM |
| RFC1 | ATAD5 | 0.016 | 0.159 | hein_WMM bioplex_WMM youn_WMM fraction |
| RFC3 | RAD17 | 0.014 | 0.137 | bioplex (RAD17) bioplex_WMM youn_WMM |
| RFC2 | RAD17 | 0.012 | 0.148 | bioplex (RAD17) bioplex_WMM |
| RFC2 | ATAD5 | 0.011 | 0.144 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RFC2 | CHTF8 | 0.011 | 0.146 | bioplex_WMM WMM_only |
| RFC1 | RAD17 | 0.01 | 0.111 | bioplex_WMM WMM_only |
| ATAD5 | RAD17 | 0.01 | 0.107 | bioplex_WMM WMM_only |
| RFC1 | CHTF8 | 0.009 | 0.113 | bioplex_WMM WMM_only |
| ATAD5 | CHTF8 | 0.009 | 0.112 | bioplex_WMM WMM_only |
| RFC1 | DSCC1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| DSCC1 | ATAD5 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| RAD17 | CHTF8 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| DSCC1 | RAD17 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| RFC3 | CHTF8 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| RFC3 | ATAD5 | 0.003 | 0.009 | hein_WMM bioplex_WMM youn_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_00874 has an average edge precision of 0.456 which is ranked 2829 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DSCC1 | HuMAP2_00874 HuMAP2_01694 HuMAP2_02712 |
| ATAD5 | HuMAP2_00874 HuMAP2_02712 HuMAP2_02847 HuMAP2_05133 |
| RFC1 | HuMAP2_00430 HuMAP2_00874 HuMAP2_02847 HuMAP2_03572 |
| RAD17 | HuMAP2_00874 HuMAP2_02712 |
| CHTF8 | HuMAP2_00874 HuMAP2_01694 HuMAP2_02712 HuMAP2_02959 |
| RFC2 | HuMAP2_00430 HuMAP2_00874 HuMAP2_02712 HuMAP2_02847 |
| RFC3 | HuMAP2_00430 HuMAP2_00874 HuMAP2_02712 HuMAP2_02847 |
| RFC4 | HuMAP2_00874 HuMAP2_02712 HuMAP2_02847 HuMAP2_05133 |
| RFC5 | HuMAP2_00430 HuMAP2_00874 HuMAP2_02712 HuMAP2_02847 |