hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00876
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HMGB2 | High mobility group protein B2 (High mobility group protein 2) (HMG-2) | UniProt NCBI |
| HMGB1 | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | UniProt NCBI |
| HMGB1P1 | NCBI | |
| SP100 | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:280 | 3.35555483123e-05 | 0.666666666667 | HMGB2 HMGB1 | HMGB1-HMGB2-HSC70-ERP60-GAPDH complex |
| REAC:R-HSA-140342 | 0.000521983812065 | 0.666666666667 | HMGB2 HMGB1 | Apoptosis induced DNA fragmentation |
| WP:WP2446 | 0.00357470816736 | 0.666666666667 | HMGB2 HMGB1 | Retinoblastoma Gene in Cancer |
| MIRNA:hsa-miR-374c-3p | 0.00532174083076 | 0.666666666667 | HMGB2 HMGB1 | hsa-miR-374c-3p |
| GO:0051101 | 0.00746165420606 | 1.0 | HMGB2 SP100 HMGB1 | regulation of DNA binding |
| REAC:R-HSA-75153 | 0.00851790571699 | 0.666666666667 | HMGB2 HMGB1 | Apoptotic execution phase |
| GO:0097100 | 0.0135228859698 | 0.666666666667 | HMGB2 HMGB1 | supercoiled DNA binding |
| GO:0050786 | 0.0378589948753 | 0.666666666667 | HMGB2 HMGB1 | RAGE receptor binding |
| GO:0051103 | 0.0378589948753 | 0.666666666667 | HMGB2 HMGB1 | DNA ligation involved in DNA repair |
| MIRNA:hsa-let-7a-2-3p | 0.0439350747985 | 0.666666666667 | HMGB2 HMGB1 | hsa-let-7a-2-3p |
| MIRNA:hsa-let-7g-3p | 0.0467934390182 | 0.666666666667 | HMGB2 HMGB1 | hsa-let-7g-3p |
| GO:0006265 | 0.0486736709081 | 0.666666666667 | HMGB2 HMGB1 | DNA topological change |
| GO:0033151 | 0.0486736709081 | 0.666666666667 | HMGB2 HMGB1 | V(D)J recombination |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HMGB1 | SP100 | 0.944 | 0.856 | bioplex (HMGB1) bioplex_WMM |
| HMGB1P1 | HMGB1 | 0.588 | 0.663 | bioplex (HMGB1) bioplex_WMM |
| HMGB2 | HMGB1 | 0.342 | 0.531 | bioplex_WMM gupta_WMM fraction |
| HMGB1P1 | SP100 | 0.008 | 0.091 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00876 has an average edge precision of 0.535 which is ranked 2304 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HMGB2 | HuMAP2_00876 HuMAP2_03246 HuMAP2_05394 HuMAP2_05836 HuMAP2_06704 |
| HMGB1 | HuMAP2_00876 HuMAP2_03246 HuMAP2_03869 HuMAP2_06344 |
| HMGB1P1 | HuMAP2_00876 HuMAP2_06344 |
| SP100 | HuMAP2_00876 HuMAP2_03869 HuMAP2_06344 |