hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00878

Confidence: High

Genename	Protein Name	Links
PCGF2	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)	UniProt NCBI
CBX8	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)	UniProt NCBI
PHC1	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)	UniProt NCBI
BMI1	Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)	UniProt NCBI
SCMH1	Polycomb protein SCMH1 (Sex comb on midleg homolog 1)	UniProt NCBI
CBX4	E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)	UniProt NCBI
CBX2	Chromobox protein homolog 2	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:115	1.13542635141e-17	0.857142857143	SCMH1 CBX4 PHC1 CBX2 BMI1 CBX8	Polycomb repressive complex 1 (PRC1, hPRC-H)
CORUM:116	2.27072192598e-17	0.857142857143	SCMH1 CBX4 PHC1 CBX2 BMI1 CBX8	Polycomb repressive complex 1 (PRC1, hPRC-H)
REAC:R-HSA-4655427	3.86614097777e-16	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	SUMOylation of DNA methylation proteins
GO:0035102	1.15597615235e-13	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	PRC1 complex
REAC:R-HSA-3899300	2.96070890203e-13	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	SUMOylation of transcription cofactors
REAC:R-HSA-4570464	4.04583533895e-13	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	SUMOylation of RNA binding proteins
REAC:R-HSA-4551638	6.36202152662e-12	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	SUMOylation of chromatin organization proteins
REAC:R-HSA-3108214	1.10273472623e-11	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	SUMOylation of DNA damage response and repair proteins
GO:0000152	1.20970476635e-10	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	nuclear ubiquitin ligase complex
GO:0031519	2.15953733604e-10	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	PcG protein complex
REAC:R-HSA-8939243	2.16151370172e-10	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
REAC:R-HSA-3108232	2.03100723442e-09	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	SUMO E3 ligases SUMOylate target proteins
REAC:R-HSA-8943724	2.39506093598e-09	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	Regulation of PTEN gene transcription
REAC:R-HSA-2990846	2.52047032694e-09	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	SUMOylation
CORUM:5513	1.3523445861e-08	0.428571428571	CBX4 BMI1 PHC1	RING1-Polycomb repressive complex
REAC:R-HSA-2559580	1.17706961511e-07	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	Oxidative Stress Induced Senescence
REAC:R-HSA-6807070	1.96582967691e-07	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	PTEN Regulation
REAC:R-HSA-2559583	1.04547497522e-06	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	Cellular Senescence
REAC:R-HSA-8878171	2.25185647673e-06	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	Transcriptional regulation by RUNX1
REAC:R-HSA-1257604	2.57913231767e-06	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	PIP3 activates AKT signaling
REAC:R-HSA-9006925	5.64016631059e-06	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	Intracellular signaling by second messengers
GO:0000151	8.59377073213e-06	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	ubiquitin ligase complex
CORUM:5518	3.02079974644e-05	0.285714285714	PHC1 BMI1	BMI1-HPH1-HPH2 complex
REAC:R-HSA-2262752	4.99176972433e-05	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	Cellular responses to stress
REAC:R-HSA-8953750	6.32191831593e-05	0.428571428571	PCGF2 BMI1 PHC1	Transcriptional Regulation by E2F6
REAC:R-HSA-212436	0.00012164166601	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	Generic Transcription Pathway
REAC:R-HSA-8953897	0.000123063682134	0.714285714286	PHC1 BMI1 CBX8 CBX2 CBX4	Cellular responses to external stimuli
REAC:R-HSA-73857	0.00023249479605	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	RNA Polymerase II Transcription
REAC:R-HSA-597592	0.00039194203242	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	Post-translational protein modification
REAC:R-HSA-74160	0.000444522787502	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	Gene expression (Transcription)
REAC:R-HSA-392499	0.00334345902737	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	Metabolism of proteins
GO:1990234	0.00351782066073	0.857142857143	PCGF2 CBX8 PHC1 CBX2 BMI1 CBX4	transferase complex
CORUM:929	0.00665530732433	0.285714285714	CBX8 BMI1	CEN complex
GO:0045892	0.0126459869113	0.857142857143	PCGF2 SCMH1 CBX4 CBX2 BMI1 CBX8	negative regulation of transcription, DNA-templated
GO:1903507	0.012821195374	0.857142857143	PCGF2 SCMH1 CBX4 CBX2 BMI1 CBX8	negative regulation of nucleic acid-templated transcription
GO:1902679	0.0129095525265	0.857142857143	PCGF2 SCMH1 CBX4 CBX2 BMI1 CBX8	negative regulation of RNA biosynthetic process
GO:0051253	0.0212806302754	0.857142857143	PCGF2 SCMH1 CBX4 CBX2 BMI1 CBX8	negative regulation of RNA metabolic process
GO:0070317	0.0245293846287	0.428571428571	PCGF2 BMI1 PHC1	negative regulation of G0 to G1 transition
GO:0070316	0.026626530587	0.428571428571	PCGF2 BMI1 PHC1	regulation of G0 to G1 transition
GO:0045023	0.0311716432999	0.428571428571	PCGF2 BMI1 PHC1	G0 to G1 transition
GO:0045934	0.0331468774122	0.857142857143	PCGF2 SCMH1 CBX4 CBX2 BMI1 CBX8	negative regulation of nucleobase-containing compound metabolic process
GO:2000113	0.0333411679743	0.857142857143	PCGF2 SCMH1 CBX4 CBX2 BMI1 CBX8	negative regulation of cellular macromolecule biosynthetic process
GO:0010558	0.0367915341449	0.857142857143	PCGF2 SCMH1 CBX4 CBX2 BMI1 CBX8	negative regulation of macromolecule biosynthetic process
GO:0016574	0.0389125948999	0.428571428571	PCGF2 BMI1 PHC1	histone ubiquitination
CORUM:0000000	0.0437772681198	0.857142857143	SCMH1 CBX4 PHC1 CBX2 BMI1 CBX8	CORUM root
GO:0031327	0.0443376193359	0.857142857143	PCGF2 SCMH1 CBX4 CBX2 BMI1 CBX8	negative regulation of cellular biosynthetic process
GO:0009890	0.0476427474477	0.857142857143	PCGF2 SCMH1 CBX4 CBX2 BMI1 CBX8	negative regulation of biosynthetic process

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PHC1	BMI1	0.997	0.93	bioplex (PHC1) bioplex_WMM
CBX8	PHC1	0.986	0.901	hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM hein (CBX8)
SCMH1	PHC1	0.965	0.874	bioplex (PHC1) bioplex_WMM
CBX8	PCGF2	0.955	0.862	bioplex (PCGF2) bioplex_WMM
PCGF2	SCMH1	0.926	0.844	bioplex (PCGF2) bioplex_WMM
CBX4	PHC1	0.864	0.801	hein_WMM bioplex (PHC1) bioplex_WMM hein (CBX4)
PCGF2	CBX2	0.765	0.749	bioplex (PCGF2) bioplex_WMM
PCGF2	PHC1	0.706	0.727	bioplex (PCGF2,PHC1) bioplex_WMM
PHC1	CBX2	0.6	0.67	hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM
PCGF2	CBX4	0.369	0.544	bioplex (PCGF2) bioplex_WMM
CBX8	CBX4	0.073	0.354	hein_WMM bioplex_WMM hein (CBX4,CBX8)
CBX8	CBX2	0.01	0.126	hein_WMM bioplex_WMM youn_WMM WMM_only
CBX8	SCMH1	0.01	0.1	bioplex_WMM WMM_only
SCMH1	CBX2	0.009	0.109	bioplex_WMM WMM_only
SCMH1	CBX4	0.009	0.09	bioplex_WMM WMM_only
CBX4	CBX2	0.009	0.098	hein_WMM bioplex_WMM WMM_only
CBX8	BMI1	0.008	0.088	bioplex_WMM WMM_only
SCMH1	BMI1	0.008	0.087	bioplex_WMM WMM_only
CBX2	BMI1	0.008	0.085	bioplex_WMM WMM_only
PCGF2	BMI1	0.008	0.085	bioplex_WMM WMM_only
CBX4	BMI1	0.008	0.066	bioplex_WMM WMM_only

Images

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Complex HuMAP2_00878 has an average edge precision of 0.438 which is ranked 2955 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PCGF2	HuMAP2_00878 HuMAP2_01063 HuMAP2_02596 HuMAP2_02601 HuMAP2_04867 HuMAP2_05374 HuMAP2_06662 HuMAP2_06693
CBX8	HuMAP2_00878 HuMAP2_01063 HuMAP2_02601 HuMAP2_04867 HuMAP2_05374 HuMAP2_06662 HuMAP2_06693
PHC1	HuMAP2_00878 HuMAP2_01063 HuMAP2_02601 HuMAP2_04867 HuMAP2_05374 HuMAP2_06662 HuMAP2_06693
BMI1	HuMAP2_00878 HuMAP2_02601 HuMAP2_05374 HuMAP2_06693
SCMH1	HuMAP2_00878 HuMAP2_02601 HuMAP2_04867 HuMAP2_05374 HuMAP2_06662 HuMAP2_06693
CBX4	HuMAP2_00878 HuMAP2_01063 HuMAP2_02601 HuMAP2_05374 HuMAP2_06693
CBX2	HuMAP2_00878 HuMAP2_02601 HuMAP2_04637 HuMAP2_04867 HuMAP2_05374 HuMAP2_06662

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00878