hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00882
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKR1C3 | Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Indanol dehydrogenase) (EC 1.1.1.112) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239) (EC 1.1.1.64) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) | UniProt NCBI |
| AKR1C1 | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2) (High-affinity hepatic bile acid-binding protein) (HBAB) (Indanol dehydrogenase) (EC 1.1.1.112) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) | UniProt NCBI |
| AKR1C2 | Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357) | UniProt NCBI |
| AKR1C4 | Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (3-alpha-HSD1) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.357) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP696 | 1.06067658052e-12 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Benzo(a)pyrene metabolism |
| GO:0009753 | 2.4395561352e-11 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | response to jasmonic acid |
| GO:0071395 | 2.4395561352e-11 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | cellular response to jasmonic acid stimulus |
| REAC:R-HSA-193807 | 6.4843220694e-11 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| REAC:R-HSA-193775 | 6.4843220694e-11 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| GO:0047086 | 1.2197780676e-10 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | ketosteroid monooxygenase activity |
| REAC:R-HSA-193368 | 5.42778567627e-10 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| GO:0032052 | 8.5384464732e-10 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | bile acid binding |
| GO:0047023 | 8.5384464732e-10 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | androsterone dehydrogenase activity |
| KEGG:00140 | 2.45312729563e-09 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Steroid hormone biosynthesis |
| REAC:R-HSA-192105 | 2.48535449387e-09 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Synthesis of bile acids and bile salts |
| GO:0044597 | 3.07384073035e-09 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | daunorubicin metabolic process |
| GO:0030638 | 3.07384073035e-09 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | polyketide metabolic process |
| GO:0030647 | 3.07384073035e-09 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | aminoglycoside antibiotic metabolic process |
| GO:0044598 | 3.07384073035e-09 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | doxorubicin metabolic process |
| GO:0042448 | 3.07384073035e-09 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | progesterone metabolic process |
| REAC:R-HSA-194068 | 5.34208379717e-09 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Bile acid and bile salt metabolism |
| GO:0004032 | 8.05053524616e-09 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | alditol:NADP+ 1-oxidoreductase activity |
| GO:0016137 | 3.32999412455e-08 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | glycoside metabolic process |
| GO:1902644 | 4.43999216606e-08 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | tertiary alcohol metabolic process |
| GO:0008106 | 5.80614360177e-08 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | alcohol dehydrogenase (NADP+) activity |
| GO:0033764 | 1.46007434692e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0004033 | 1.7845353129e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | aldo-keto reductase (NADP) activity |
| GO:0016229 | 2.59227234926e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | steroid dehydrogenase activity |
| GO:0018636 | 3.63274304092e-07 | 0.75 | AKR1C3 AKR1C1 AKR1C2 | phenanthrene 9,10-monooxygenase activity |
| WP:WP702 | 3.88465236507e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Metapathway biotransformation Phase I and II |
| GO:0016709 | 4.28142101727e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| GO:1901661 | 4.28142101727e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | quinone metabolic process |
| GO:0006692 | 4.99499118682e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | prostanoid metabolic process |
| GO:0006693 | 4.99499118682e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | prostaglandin metabolic process |
| GO:0008207 | 5.79418977671e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | C21-steroid hormone metabolic process |
| REAC:R-HSA-8957322 | 9.07725736124e-07 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Metabolism of steroids |
| WP:WP98 | 1.47440886056e-06 | 0.75 | AKR1C3 AKR1C1 AKR1C2 | Prostaglandin Synthesis and Regulation |
| GO:0019748 | 2.22951035196e-06 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | secondary metabolic process |
| GO:0033293 | 3.98098967922e-06 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | monocarboxylic acid binding |
| GO:0016655 | 6.60448834702e-06 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:0034308 | 8.3202281769e-06 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | primary alcohol metabolic process |
| REAC:R-HSA-975634 | 1.436837348e-05 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 1.78485863117e-05 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | Metabolism of fat-soluble vitamins |
| GO:0004497 | 2.10899871844e-05 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | monooxygenase activity |
| GO:1901657 | 3.30139032886e-05 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | glycosyl compound metabolic process |
| GO:0034754 | 3.66543553269e-05 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | cellular hormone metabolic process |
| GO:0006690 | 4.26693005383e-05 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | icosanoid metabolic process |
| GO:0033559 | 4.26693005383e-05 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | unsaturated fatty acid metabolic process |
| GO:0016999 | 4.70712600242e-05 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | antibiotic metabolic process |
| GO:0016651 | 5.18053162868e-05 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | oxidoreductase activity, acting on NAD(P)H |
| WP:WP4524 | 6.04452397492e-05 | 0.5 | AKR1C4 AKR1C2 | The alternative pathway of fetal androgen synthesis |
| GO:0071229 | 8.81235983606e-05 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | cellular response to acid chemical |
| REAC:R-HSA-2187338 | 9.08592662777e-05 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | Visual phototransduction |
| GO:0016616 | 9.96052473331e-05 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0031406 | 0.000121189586173 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | carboxylic acid binding |
| GO:0016614 | 0.000130738130864 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0043177 | 0.000174678196193 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | organic acid binding |
| GO:0016705 | 0.000207250295865 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| GO:0001101 | 0.000252118978237 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | response to acid chemical |
| GO:1901568 | 0.000252118978237 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | fatty acid derivative metabolic process |
| GO:0016628 | 0.000296207880886 | 0.75 | AKR1C3 AKR1C1 AKR1C2 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| GO:0042445 | 0.000332604936228 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | hormone metabolic process |
| GO:0097164 | 0.000332604936228 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | ammonium ion metabolic process |
| REAC:R-HSA-556833 | 0.00062411608996 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Metabolism of lipids |
| GO:0042180 | 0.000942422491033 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | cellular ketone metabolic process |
| REAC:R-HSA-196854 | 0.00107722817591 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | Metabolism of vitamins and cofactors |
| HP:0012245 | 0.00124917537299 | 0.5 | AKR1C4 AKR1C2 | Sex reversal |
| GO:0008202 | 0.00207257982907 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | steroid metabolic process |
| GO:0047115 | 0.00270494046827 | 0.5 | AKR1C1 AKR1C2 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity |
| HP:0012244 | 0.00308721029257 | 0.5 | AKR1C4 AKR1C2 | Abnormal sex determination |
| GO:0006066 | 0.00323396102168 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | alcohol metabolic process |
| REAC:R-HSA-418594 | 0.00390449052912 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | G alpha (i) signalling events |
| GO:0006631 | 0.00460927796737 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | fatty acid metabolic process |
| GO:0016627 | 0.00514395792508 | 0.75 | AKR1C3 AKR1C1 AKR1C2 | oxidoreductase activity, acting on the CH-CH group of donors |
| GO:0010817 | 0.00647380744814 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | regulation of hormone levels |
| GO:0071799 | 0.00811409485621 | 0.5 | AKR1C3 AKR1C2 | cellular response to prostaglandin D stimulus |
| GO:0071798 | 0.00811409485621 | 0.5 | AKR1C3 AKR1C2 | response to prostaglandin D |
| GO:1901615 | 0.0122750656924 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | organic hydroxy compound metabolic process |
| HP:0000037 | 0.0142767163782 | 0.5 | AKR1C4 AKR1C2 | Male pseudohermaphroditism |
| GO:0051186 | 0.0171677071312 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | cofactor metabolic process |
| GO:0001523 | 0.0225145500348 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | retinoid metabolic process |
| GO:0016101 | 0.0244411426287 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | diterpenoid metabolic process |
| GO:0032870 | 0.0274825106713 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | cellular response to hormone stimulus |
| GO:0006721 | 0.0320435644688 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | terpenoid metabolic process |
| REAC:R-HSA-388396 | 0.0339148209768 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | GPCR downstream signalling |
| GO:0017144 | 0.0339498695187 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | drug metabolic process |
| REAC:R-HSA-372790 | 0.0432949536543 | 0.75 | AKR1C3 AKR1C1 AKR1C4 | Signaling by GPCR |
| REAC:R-HSA-1430728 | 0.0467536218007 | 1.0 | AKR1C3 AKR1C1 AKR1C4 AKR1C2 | Metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKR1C2 | AKR1C1 | 1.0 | 0.949 | bioplex (AKR1C1,AKR1C2) bioplex_WMM |
| AKR1C1 | AKR1C3 | 1.0 | 0.949 | bioplex (AKR1C1,AKR1C3) bioplex_WMM treiber_WMM |
| AKR1C3 | AKR1C4 | 0.95 | 0.858 | bioplex (AKR1C3,AKR1C4) bioplex_WMM |
| AKR1C2 | AKR1C4 | 0.208 | 0.456 | bioplex (AKR1C2) bioplex_WMM |
| AKR1C2 | AKR1C3 | 0.072 | 0.356 | bioplex (AKR1C2) bioplex_WMM |
| AKR1C1 | AKR1C4 | 0.011 | 0.142 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00882 has an average edge precision of 0.618 which is ranked 1845 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AKR1C3 | HuMAP2_00882 HuMAP2_01811 HuMAP2_03661 |
| AKR1C1 | HuMAP2_00882 HuMAP2_01552 HuMAP2_03132 HuMAP2_06910 |
| AKR1C2 | HuMAP2_00697 HuMAP2_00882 HuMAP2_01552 |
| AKR1C4 | HuMAP2_00882 HuMAP2_01811 HuMAP2_03661 HuMAP2_05598 |