hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00900

Confidence: Medium High

Genename	Protein Name	Links
KDM2B	Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)	UniProt NCBI
RNF2	E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)	UniProt NCBI
PCGF6	Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)	UniProt NCBI
PCGF1	Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)	UniProt NCBI
RYBP	RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)	UniProt NCBI
FBRS	Probable fibrosin-1	UniProt NCBI
BMI1	Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)	UniProt NCBI
RING1	E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)	UniProt NCBI
BCOR	BCL-6 corepressor (BCoR)	UniProt NCBI
PCGF5	Polycomb group RING finger protein 5 (RING finger protein 159)	UniProt NCBI
YAF2	YY1-associated factor 2	UniProt NCBI
BCORL1	BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0035518	2.69313455497e-21	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	histone H2A monoubiquitination
GO:0033522	2.25998440861e-19	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	histone H2A ubiquitination
GO:0010390	1.10707768716e-18	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	histone monoubiquitination
GO:0016574	6.21786443834e-17	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	histone ubiquitination
CORUM:1178	1.05892865796e-16	0.5	KDM2B RYBP PCGF1 RNF2 RING1 BCOR	BCOR complex
GO:0006513	1.38147890084e-15	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	protein monoubiquitination
GO:0031519	1.06758810447e-13	0.666666666667	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5	PcG protein complex
GO:0035102	1.52193881718e-11	0.5	BMI1 PCGF1 RNF2 PCGF6 PCGF5 RING1	PRC1 complex
REAC:R-HSA-8953750	1.96272976681e-11	0.5	BMI1 RYBP YAF2 RNF2 PCGF6 RING1	Transcriptional Regulation by E2F6
REAC:R-HSA-8939243	2.84060773817e-11	0.5	BMI1 RYBP YAF2 RNF2 RING1 PCGF5	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
GO:0000152	3.28247795182e-11	0.583333333333	RING1 PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	nuclear ubiquitin ligase complex
GO:0036353	3.62901491464e-10	0.416666666667	PCGF6 BMI1 PCGF5 PCGF1 RNF2	histone H2A-K119 monoubiquitination
GO:0070317	7.0157056891e-09	0.5	BMI1 RYBP YAF2 RNF2 PCGF6 RING1	negative regulation of G0 to G1 transition
CORUM:1194	7.39081461508e-09	0.333333333333	PCGF6 YAF2 RNF2 RING1	E2F-6 complex
GO:0070316	8.32826801629e-09	0.5	BMI1 RYBP YAF2 RNF2 PCGF6 RING1	regulation of G0 to G1 transition
GO:0016570	1.04382657555e-08	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	histone modification
GO:0045023	1.15713981364e-08	0.5	BMI1 RYBP YAF2 RNF2 PCGF6 RING1	G0 to G1 transition
GO:0016569	1.57015593836e-08	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	covalent chromatin modification
CORUM:1462	9.91118107838e-08	0.25	RING1 RNF2 BMI1	hPRC1L complex
WP:WP4553	7.44074048695e-07	0.333333333333	KDM2B PCGF1 RNF2 BCOR	FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma
GO:0016567	1.6175951544e-06	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	protein ubiquitination
REAC:R-HSA-8878171	1.95691292464e-06	0.5	BMI1 RYBP YAF2 RNF2 RING1 PCGF5	Transcriptional regulation by RUNX1
GO:0006325	1.98027939023e-06	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	chromatin organization
CORUM:115	4.07540599934e-06	0.25	RING1 RNF2 BMI1	Polycomb repressive complex 1 (PRC1, hPRC-H)
GO:0032446	4.76285259875e-06	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	protein modification by small protein conjugation
CORUM:116	5.43141106091e-06	0.25	RING1 RNF2 BMI1	Polycomb repressive complex 1 (PRC1, hPRC-H)
GO:0000151	1.54467467956e-05	0.583333333333	RING1 PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	ubiquitin ligase complex
GO:0070647	3.86552003447e-05	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	protein modification by small protein conjugation or removal
REAC:R-HSA-4655427	4.36792550508e-05	0.25	RING1 RNF2 BMI1	SUMOylation of DNA methylation proteins
KEGG:04550	9.4683767197e-05	0.333333333333	PCGF6 BMI1 PCGF1 PCGF5	Signaling pathways regulating pluripotency of stem cells
GO:0051276	0.000126452906721	0.75	KDM2B RING1 RYBP PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	chromosome organization
CORUM:929	0.000189664432438	0.25	RING1 RNF2 BMI1	CEN complex
CORUM:5513	0.00022129809732	0.166666666667	RING1 BMI1	RING1-Polycomb repressive complex
REAC:R-HSA-3899300	0.00093776778838	0.25	RING1 RNF2 BMI1	SUMOylation of transcription cofactors
REAC:R-HSA-212436	0.00106938555608	0.583333333333	RING1 RYBP YAF2 RNF2 PCGF6 BMI1 PCGF5	Generic Transcription Pathway
REAC:R-HSA-4570464	0.00108864452696	0.25	RING1 RNF2 BMI1	SUMOylation of RNA binding proteins
GO:0010948	0.00199509959332	0.5	BMI1 RYBP YAF2 RNF2 PCGF6 RING1	negative regulation of cell cycle process
REAC:R-HSA-73857	0.00221339958121	0.583333333333	RING1 RYBP YAF2 RNF2 PCGF6 BMI1 PCGF5	RNA Polymerase II Transcription
GO:0045892	0.00254147261806	0.666666666667	KDM2B RING1 YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of transcription, DNA-templated
GO:1903507	0.00258770289618	0.666666666667	KDM2B RING1 YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of nucleic acid-templated transcription
GO:1902679	0.00261109042217	0.666666666667	KDM2B RING1 YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of RNA biosynthetic process
REAC:R-HSA-8943724	0.00275588909515	0.25	RING1 RNF2 BMI1	Regulation of PTEN gene transcription
REAC:R-HSA-4551638	0.00409913921722	0.25	RING1 RNF2 BMI1	SUMOylation of chromatin organization proteins
REAC:R-HSA-74160	0.00456646756103	0.583333333333	RING1 RYBP YAF2 RNF2 PCGF6 BMI1 PCGF5	Gene expression (Transcription)
GO:0051253	0.00502269773686	0.666666666667	KDM2B RING1 YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of RNA metabolic process
REAC:R-HSA-3108214	0.00534910402887	0.25	RING1 RNF2 BMI1	SUMOylation of DNA damage response and repair proteins
GO:0006355	0.00748109957418	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	regulation of transcription, DNA-templated
GO:1903506	0.00769215564192	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	regulation of nucleic acid-templated transcription
GO:2001141	0.00779966533083	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	regulation of RNA biosynthetic process
GO:0045934	0.00896131306359	0.666666666667	KDM2B RING1 YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of nucleobase-containing compound metabolic process
GO:2000113	0.0090299336665	0.666666666667	KDM2B RING1 YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of cellular macromolecule biosynthetic process
GO:0010558	0.0102681659799	0.666666666667	KDM2B RING1 YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of macromolecule biosynthetic process
CORUM:0000000	0.0120685533371	0.75	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	CORUM root
GO:0031327	0.0130966176606	0.666666666667	KDM2B RING1 YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of cellular biosynthetic process
GO:0051172	0.0132268107271	0.75	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of nitrogen compound metabolic process
GO:0009890	0.0143832293773	0.666666666667	KDM2B RING1 YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of biosynthetic process
GO:1990234	0.0156829367896	0.583333333333	RING1 PCGF1 RNF2 PCGF6 BMI1 PCGF5 BCOR	transferase complex
GO:0006351	0.0164484541196	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	transcription, DNA-templated
GO:0097659	0.016874576279	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	nucleic acid-templated transcription
GO:0032774	0.0173105258968	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	RNA biosynthetic process
GO:0051252	0.0211764735068	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	regulation of RNA metabolic process
REAC:R-HSA-2559580	0.0269983989954	0.25	RING1 RNF2 BMI1	Oxidative Stress Induced Senescence
GO:0031324	0.0282935163802	0.75	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR	negative regulation of cellular metabolic process
GO:2000112	0.0312926117342	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	regulation of cellular macromolecule biosynthetic process
REAC:R-HSA-6807070	0.0364531078151	0.25	RING1 RNF2 BMI1	PTEN Regulation
GO:0010556	0.0378120277533	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	regulation of macromolecule biosynthetic process
GO:0019219	0.0480129755252	0.833333333333	KDM2B RING1 RYBP YAF2 PCGF1 PCGF6 BMI1 RNF2 BCOR PCGF5	regulation of nucleobase-containing compound metabolic process
GO:0045786	0.0497540351511	0.5	BMI1 RYBP YAF2 RNF2 PCGF6 RING1	negative regulation of cell cycle

Edges

Protein 1	Protein 2	Score	Precision	Evidence
RYBP	RNF2	1.0	0.949	hein_WMM bioplex (RYBP) bioplex_WMM hein (RNF2)
RING1	RYBP	1.0	0.949	hein_WMM bioplex (RYBP) bioplex_WMM hein (RING1)
PCGF1	RYBP	0.999	0.949	hein_WMM bioplex (RYBP) bioplex_WMM hein (PCGF1)
FBRS	PCGF5	0.992	0.912	bioplex (PCGF5) bioplex_WMM boldt youn_WMM boldt_WMM
FBRS	RYBP	0.932	0.846	hein_WMM bioplex (RYBP) bioplex_WMM
RYBP	BMI1	0.918	0.841	hein_WMM bioplex (RYBP) bioplex_WMM
RING1	YAF2	0.892	0.819	hein_WMM bioplex (YAF2) bioplex_WMM hein (RING1)
YAF2	RNF2	0.888	0.818	hein_WMM bioplex (YAF2) bioplex_WMM hein (RNF2)
BCOR	RYBP	0.863	0.799	hein_WMM bioplex (RYBP) bioplex_WMM
PCGF6	RNF2	0.812	0.771	hein_WMM bioplex (PCGF6) bioplex_WMM hein (RNF2)
KDM2B	RYBP	0.772	0.751	hein_WMM bioplex (RYBP) bioplex_WMM
PCGF6	RYBP	0.77	0.749	hein_WMM bioplex (PCGF6,RYBP) bioplex_WMM
PCGF1	YAF2	0.726	0.736	hein_WMM bioplex (YAF2) bioplex_WMM hein (PCGF1)
PCGF6	RING1	0.707	0.729	hein_WMM bioplex (PCGF6) bioplex_WMM youn_WMM hein (RING1) gupta_WMM
PCGF5	RYBP	0.585	0.663	bioplex (PCGF5,RYBP) bioplex_WMM
RING1	RNF2	0.551	0.644	hein_WMM bioplex_WMM hein (RING1,RNF2) boldt_WMM
PCGF5	RNF2	0.365	0.544	hein_WMM bioplex (PCGF5) bioplex_WMM boldt boldt_WMM
PCGF5	RING1	0.361	0.544	hein_WMM bioplex (PCGF5) bioplex_WMM youn_WMM boldt_WMM
FBRS	RNF2	0.301	0.496	hein_WMM bioplex_WMM boldt hein (RNF2) gupta_WMM boldt_WMM
PCGF1	KDM2B	0.264	0.482	hein_WMM bioplex_WMM youn_WMM hein (PCGF1) gupta_WMM
PCGF6	BCORL1	0.234	0.471	bioplex (PCGF6) bioplex_WMM youn_WMM
FBRS	YAF2	0.226	0.468	hein_WMM bioplex (YAF2) bioplex_WMM
YAF2	BCOR	0.196	0.45	hein_WMM bioplex (YAF2) bioplex_WMM hein (BCOR)
PCGF1	BCOR	0.144	0.407	hein_WMM bioplex_WMM youn_WMM hein (BCOR,PCGF1) gupta_WMM
YAF2	KDM2B	0.141	0.405	hein_WMM bioplex (YAF2) bioplex_WMM
YAF2	RYBP	0.133	0.405	hein_WMM bioplex (YAF2) bioplex_WMM
PCGF5	YAF2	0.122	0.394	bioplex (PCGF5,YAF2) bioplex_WMM
RYBP	BCORL1	0.118	0.392	hein_WMM bioplex (RYBP) bioplex_WMM
PCGF6	YAF2	0.093	0.355	hein_WMM bioplex (PCGF6,YAF2) bioplex_WMM
YAF2	BMI1	0.088	0.353	hein_WMM bioplex (YAF2) bioplex_WMM
FBRS	RING1	0.085	0.35	hein_WMM bioplex_WMM youn_WMM hein (RING1) boldt_WMM
RNF2	BMI1	0.068	0.35	hein_WMM bioplex_WMM hein (RNF2)
RING1	PCGF1	0.064	0.348	hein_WMM bioplex_WMM youn_WMM hein (PCGF1,RING1) gupta_WMM
FBRS	PCGF6	0.061	0.336	hein_WMM bioplex (PCGF6) bioplex_WMM youn_WMM
RING1	BMI1	0.042	0.27	hein_WMM bioplex_WMM hein (RING1)
BCOR	KDM2B	0.04	0.267	hein_WMM bioplex_WMM youn_WMM hein (BCOR) gupta_WMM
PCGF1	BCORL1	0.027	0.228	hein_WMM bioplex_WMM youn_WMM hein (PCGF1)
YAF2	BCORL1	0.025	0.218	hein_WMM bioplex (YAF2) bioplex_WMM
RING1	BCOR	0.018	0.182	hein_WMM bioplex_WMM youn_WMM hein (BCOR,RING1) gupta_WMM
PCGF1	RNF2	0.017	0.166	hein_WMM bioplex_WMM hein (PCGF1,RNF2) gupta_WMM
BCOR	RNF2	0.014	0.137	hein_WMM bioplex_WMM hein (BCOR,RNF2) gupta_WMM
PCGF1	BMI1	0.013	0.155	hein_WMM bioplex_WMM WMM_only
RING1	KDM2B	0.012	0.145	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
FBRS	KDM2B	0.011	0.144	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
FBRS	PCGF1	0.011	0.142	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
RING1	BCORL1	0.011	0.138	hein_WMM bioplex_WMM youn_WMM WMM_only
KDM2B	BCORL1	0.011	0.145	hein_WMM bioplex_WMM youn_WMM WMM_only
PCGF6	PCGF1	0.011	0.145	hein_WMM bioplex_WMM youn_WMM WMM_only
PCGF5	KDM2B	0.011	0.141	bioplex_WMM youn_WMM WMM_only
FBRS	BMI1	0.01	0.132	hein_WMM bioplex_WMM WMM_only
RNF2	BCORL1	0.01	0.129	hein_WMM bioplex_WMM WMM_only
KDM2B	BMI1	0.01	0.122	hein_WMM bioplex_WMM WMM_only
PCGF6	BMI1	0.01	0.12	hein_WMM bioplex_WMM WMM_only
FBRS	BCORL1	0.01	0.1	bioplex_WMM youn_WMM WMM_only
BMI1	BCORL1	0.01	0.099	bioplex_WMM WMM_only
PCGF5	PCGF1	0.01	0.098	bioplex_WMM youn_WMM WMM_only
PCGF6	KDM2B	0.01	0.1	hein_WMM bioplex_WMM youn_WMM WMM_only
PCGF5	BCORL1	0.009	0.106	bioplex_WMM youn_WMM WMM_only
BCOR	BCORL1	0.009	0.09	hein_WMM bioplex_WMM youn_WMM WMM_only
PCGF5	BMI1	0.008	0.084	hein_WMM bioplex_WMM WMM_only
FBRS	BCOR	0.008	0.083	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
BCOR	BMI1	0.008	0.08	hein_WMM bioplex_WMM WMM_only
PCGF5	PCGF6	0.008	0.079	bioplex_WMM youn_WMM WMM_only
PCGF6	BCOR	0.008	0.051	hein_WMM bioplex_WMM youn_WMM WMM_only
PCGF5	BCOR	0.007	0.004	hein_WMM bioplex_WMM youn_WMM WMM_only
KDM2B	RNF2	0.007	0.004	hein_WMM bioplex_WMM hein (RNF2) gupta_WMM

Images

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Complex HuMAP2_00900 has an average edge precision of 0.372 which is ranked 3613 out of all 6965 complexes.

Related Complexes

Genename	Complexes
KDM2B	HuMAP2_00900 HuMAP2_02200 HuMAP2_02465 HuMAP2_02596 HuMAP2_02730
RNF2	HuMAP2_00900 HuMAP2_02200 HuMAP2_02596 HuMAP2_02601 HuMAP2_02730
PCGF6	HuMAP2_00900 HuMAP2_01696 HuMAP2_01963 HuMAP2_02200 HuMAP2_02290 HuMAP2_02596 HuMAP2_06770
PCGF1	HuMAP2_00900 HuMAP2_02200 HuMAP2_02465 HuMAP2_02596 HuMAP2_02730
RYBP	HuMAP2_00900 HuMAP2_02200 HuMAP2_02465 HuMAP2_02596 HuMAP2_02730
FBRS	HuMAP2_00262 HuMAP2_00900 HuMAP2_02596 HuMAP2_02730
BMI1	HuMAP2_00900 HuMAP2_02596 HuMAP2_02601 HuMAP2_02730 HuMAP2_04333
RING1	HuMAP2_00900 HuMAP2_02200 HuMAP2_02596 HuMAP2_02601 HuMAP2_02730
BCOR	HuMAP2_00900 HuMAP2_02200 HuMAP2_02465 HuMAP2_02596 HuMAP2_02730
PCGF5	HuMAP2_00262 HuMAP2_00900 HuMAP2_02596 HuMAP2_02730 HuMAP2_05042
YAF2	HuMAP2_00900 HuMAP2_02200 HuMAP2_02465 HuMAP2_02596 HuMAP2_02730
BCORL1	HuMAP2_00900 HuMAP2_02290 HuMAP2_02465 HuMAP2_02596 HuMAP2_02730 HuMAP2_06770

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00900