hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00901
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MCM2 | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | UniProt NCBI |
| MCM4 | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | UniProt NCBI |
| MCM6 | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2792 | 9.0142507219e-10 | 1.0 | MCM6 MCM2 MCM4 | MCM2-MCM4-MCM6-MCM7 complex |
| CORUM:387 | 4.50712536095e-09 | 1.0 | MCM6 MCM2 MCM4 | MCM complex |
| CORUM:5611 | 6.44518926616e-08 | 1.0 | MCM6 MCM2 MCM4 | Emerin complex 24 |
| REAC:R-HSA-176974 | 9.89113204212e-08 | 1.0 | MCM6 MCM2 MCM4 | Unwinding of DNA |
| KEGG:03030 | 2.14716765829e-07 | 1.0 | MCM6 MCM2 MCM4 | DNA replication |
| WP:WP466 | 7.39430675706e-07 | 1.0 | MCM6 MCM2 MCM4 | DNA Replication |
| REAC:R-HSA-69190 | 2.23000067859e-06 | 1.0 | MCM6 MCM2 MCM4 | DNA strand elongation |
| REAC:R-HSA-68962 | 2.45300074645e-06 | 1.0 | MCM6 MCM2 MCM4 | Activation of the pre-replicative complex |
| WP:WP45 | 2.55779891663e-06 | 1.0 | MCM6 MCM2 MCM4 | G1 to S cell cycle control |
| GO:0006267 | 3.17865016081e-06 | 1.0 | MCM6 MCM2 MCM4 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication |
| GO:1902299 | 3.17865016081e-06 | 1.0 | MCM6 MCM2 MCM4 | pre-replicative complex assembly involved in cell cycle DNA replication |
| GO:0036388 | 3.17865016081e-06 | 1.0 | MCM6 MCM2 MCM4 | pre-replicative complex assembly |
| REAC:R-HSA-176187 | 3.49336799851e-06 | 1.0 | MCM6 MCM2 MCM4 | Activation of ATR in response to replication stress |
| KEGG:04110 | 8.44552612263e-06 | 1.0 | MCM6 MCM2 MCM4 | Cell cycle |
| CORUM:1452 | 1.00675659188e-05 | 0.666666666667 | MCM6 MCM2 | MCM2-MCM6-MCM7 complex |
| CORUM:2791 | 1.00675659188e-05 | 0.666666666667 | MCM6 MCM4 | MCM4-MCM6-MCM7 complex |
| GO:0000727 | 1.49850650438e-05 | 1.0 | MCM6 MCM2 MCM4 | double-strand break repair via break-induced replication |
| GO:1902969 | 1.49850650438e-05 | 1.0 | MCM6 MCM2 MCM4 | mitotic DNA replication |
| WP:WP179 | 1.63254441694e-05 | 1.0 | MCM6 MCM2 MCM4 | Cell Cycle |
| GO:0042555 | 1.99800867251e-05 | 1.0 | MCM6 MCM2 MCM4 | MCM complex |
| REAC:R-HSA-68867 | 2.2531998792e-05 | 1.0 | MCM6 MCM2 MCM4 | Assembly of the pre-replicative complex |
| REAC:R-HSA-68949 | 2.56967114485e-05 | 1.0 | MCM6 MCM2 MCM4 | Orc1 removal from chromatin |
| GO:0006268 | 3.30579616724e-05 | 1.0 | MCM6 MCM2 MCM4 | DNA unwinding involved in DNA replication |
| REAC:R-HSA-69002 | 4.44066869e-05 | 1.0 | MCM6 MCM2 MCM4 | DNA Replication Pre-Initiation |
| REAC:R-HSA-69052 | 5.10580236014e-05 | 1.0 | MCM6 MCM2 MCM4 | Switching of origins to a post-replicative state |
| WP:WP4352 | 0.000100842112761 | 1.0 | MCM6 MCM2 MCM4 | Ciliary landscape |
| REAC:R-HSA-69239 | 0.000120004609098 | 1.0 | MCM6 MCM2 MCM4 | Synthesis of DNA |
| REAC:R-HSA-69306 | 0.000146343794532 | 1.0 | MCM6 MCM2 MCM4 | DNA Replication |
| REAC:R-HSA-69206 | 0.000160847790881 | 1.0 | MCM6 MCM2 MCM4 | G1/S Transition |
| GO:0003688 | 0.000183816797871 | 1.0 | MCM6 MCM2 MCM4 | DNA replication origin binding |
| REAC:R-HSA-453279 | 0.000233190181847 | 1.0 | MCM6 MCM2 MCM4 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 0.000295546575822 | 1.0 | MCM6 MCM2 MCM4 | S Phase |
| REAC:R-HSA-69481 | 0.00034275245309 | 1.0 | MCM6 MCM2 MCM4 | G2/M Checkpoints |
| REAC:R-HSA-69620 | 0.00175293114833 | 1.0 | MCM6 MCM2 MCM4 | Cell Cycle Checkpoints |
| GO:0032508 | 0.00200709053011 | 1.0 | MCM6 MCM2 MCM4 | DNA duplex unwinding |
| GO:0033260 | 0.00200709053011 | 1.0 | MCM6 MCM2 MCM4 | nuclear DNA replication |
| GO:0044786 | 0.00251749092736 | 1.0 | MCM6 MCM2 MCM4 | cell cycle DNA replication |
| GO:0003678 | 0.00265735153444 | 1.0 | MCM6 MCM2 MCM4 | DNA helicase activity |
| GO:0032392 | 0.00343475854519 | 1.0 | MCM6 MCM2 MCM4 | DNA geometric change |
| WP:WP2446 | 0.00357470816736 | 0.666666666667 | MCM6 MCM4 | Retinoblastoma Gene in Cancer |
| GO:1902315 | 0.00811409485621 | 0.666666666667 | MCM2 MCM4 | nuclear cell cycle DNA replication initiation |
| GO:1902975 | 0.00811409485621 | 0.666666666667 | MCM2 MCM4 | mitotic DNA replication initiation |
| GO:1902292 | 0.00811409485621 | 0.666666666667 | MCM2 MCM4 | cell cycle DNA replication initiation |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | MCM6 MCM2 MCM4 | Cell Cycle, Mitotic |
| GO:0004386 | 0.0106693663112 | 1.0 | MCM6 MCM2 MCM4 | helicase activity |
| GO:0008094 | 0.011404996777 | 1.0 | MCM6 MCM2 MCM4 | DNA-dependent ATPase activity |
| GO:0003697 | 0.0125706532002 | 1.0 | MCM6 MCM2 MCM4 | single-stranded DNA binding |
| MIRNA:hsa-miR-501-3p | 0.0166420052318 | 0.666666666667 | MCM2 MCM4 | hsa-miR-501-3p |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | MCM6 MCM2 MCM4 | Cell Cycle |
| GO:0000784 | 0.0242409310378 | 1.0 | MCM6 MCM2 MCM4 | nuclear chromosome, telomeric region |
| GO:0000724 | 0.0268132763851 | 1.0 | MCM6 MCM2 MCM4 | double-strand break repair via homologous recombination |
| GO:0000725 | 0.0268132763851 | 1.0 | MCM6 MCM2 MCM4 | recombinational repair |
| GO:0006261 | 0.0302766427817 | 1.0 | MCM6 MCM2 MCM4 | DNA-dependent DNA replication |
| MIRNA:hsa-miR-34a-5p | 0.0363069216771 | 1.0 | MCM6 MCM2 MCM4 | hsa-miR-34a-5p |
| GO:0000781 | 0.0397775372938 | 1.0 | MCM6 MCM2 MCM4 | chromosome, telomeric region |
| CORUM:6261 | 0.0499776345577 | 0.333333333333 | MCM2 | Histone-2-Histone-4-ASF1-MCM2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MCM6 | MCM2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (MCM2,MCM6) Malo fraction boldt_WMM treiber_WMM |
| MCM6 | MCM4 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (MCM6) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM2 | MCM4 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (MCM2) Malo fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_00901 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MCM2 | HuMAP2_00191 HuMAP2_00901 HuMAP2_02127 HuMAP2_03737 HuMAP2_05922 |
| MCM4 | HuMAP2_00191 HuMAP2_00486 HuMAP2_00901 HuMAP2_02127 HuMAP2_03737 HuMAP2_05922 |
| MCM6 | HuMAP2_00191 HuMAP2_00901 HuMAP2_02127 HuMAP2_03737 HuMAP2_05922 |