hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00906
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DDOST | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) | UniProt NCBI |
| MAGT1 | Magnesium transporter protein 1 (MagT1) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1) (Oligosaccharyl transferase subunit MAGT1) (Implantation-associated protein) (IAP) | UniProt NCBI |
| STT3B | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) | UniProt NCBI |
| SEC61A1 | Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) | UniProt NCBI |
| SEC63 | Translocation protein SEC63 homolog | UniProt NCBI |
| JAGN1 | Protein jagunal homolog 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1200 | 7.88270302729e-08 | 0.5 | STT3B DDOST MAGT1 | Oligosaccharyltransferase complex (Stt3B variant) |
| KEGG:04141 | 8.11848952866e-06 | 0.666666666667 | STT3B SEC63 DDOST SEC61A1 | Protein processing in endoplasmic reticulum |
| HP:0001871 | 4.69543107407e-05 | 1.0 | STT3B DDOST JAGN1 SEC63 MAGT1 SEC61A1 | Abnormality of blood and blood-forming tissues |
| CORUM:1199 | 0.000125760085813 | 0.333333333333 | DDOST MAGT1 | Oligosaccharyltransferase complex (Stt3A variant) |
| GO:0004579 | 0.000152436922042 | 0.5 | STT3B DDOST MAGT1 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| GO:0004576 | 0.000217734118711 | 0.5 | STT3B DDOST MAGT1 | oligosaccharyl transferase activity |
| GO:0008250 | 0.000299339163023 | 0.5 | STT3B DDOST MAGT1 | oligosaccharyltransferase complex |
| KEGG:03060 | 0.00157819534506 | 0.333333333333 | SEC61A1 SEC63 | Protein export |
| KEGG:00513 | 0.00392074818894 | 0.333333333333 | STT3B DDOST | Various types of N-glycan biosynthesis |
| KEGG:00510 | 0.00587890830807 | 0.333333333333 | STT3B DDOST | N-Glycan biosynthesis |
| GO:0018279 | 0.00734442516369 | 0.5 | STT3B DDOST MAGT1 | protein N-linked glycosylation via asparagine |
| GO:0018196 | 0.00813009778332 | 0.5 | STT3B DDOST MAGT1 | peptidyl-asparagine modification |
| HP:0002719 | 0.0161802990134 | 0.666666666667 | SEC61A1 JAGN1 MAGT1 DDOST | Recurrent infections |
| HP:0032101 | 0.0215996916698 | 0.666666666667 | SEC61A1 JAGN1 MAGT1 DDOST | Unusual infection |
| GO:0005783 | 0.023225190532 | 1.0 | STT3B DDOST JAGN1 SEC63 MAGT1 SEC61A1 | endoplasmic reticulum |
| HP:0012345 | 0.0394527338604 | 0.333333333333 | STT3B DDOST | Abnormal glycosylation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAGT1 | STT3B | 0.637 | 0.684 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MAGT1 | DDOST | 0.205 | 0.454 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SEC61A1 | DDOST | 0.087 | 0.353 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| JAGN1 | DDOST | 0.029 | 0.232 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SEC61A1 | SEC63 | 0.028 | 0.231 | bioplex (SEC63) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MAGT1 | SEC61A1 | 0.026 | 0.22 | bioplex (SEC61A1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| JAGN1 | SEC61A1 | 0.026 | 0.22 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| MAGT1 | JAGN1 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| STT3B | JAGN1 | 0.007 | 0.004 | youn_WMM gupta_WMM WMM_only |
| JAGN1 | SEC63 | 0.007 | 0.0 | youn_WMM gupta_WMM WMM_only |
| STT3B | SEC63 | 0.006 | 0.008 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| SEC63 | DDOST | 0.004 | 0.017 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| STT3B | SEC61A1 | 0.003 | 0.013 | hein_WMM bioplex (SEC61A1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| STT3B | DDOST | 0.003 | 0.013 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MAGT1 | SEC63 | 0.003 | 0.011 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_00906 has an average edge precision of 0.164 which is ranked 6585 out of all 6965 complexes.
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