hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00912
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS26C | Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A) | UniProt NCBI |
| COMMD10 | COMM domain-containing protein 10 | UniProt NCBI |
| VPS35L | VPS35 endosomal protein sorting factor-like (Esophageal cancer-associated protein) | UniProt NCBI |
| COMMD3 | COMM domain-containing protein 3 (Protein Bup) (Protein PIL) | UniProt NCBI |
| CCDC22 | Coiled-coil domain-containing protein 22 | UniProt NCBI |
| COMMD2 | COMM domain-containing protein 2 | UniProt NCBI |
| COMMD6 | COMM domain-containing protein 6 | UniProt NCBI |
| COMMD7 | COMM domain-containing protein 7 | UniProt NCBI |
| DENND10 | Protein FAM45A | UniProt NCBI |
| COMMD5 | COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG) | UniProt NCBI |
| COMMD9 | COMM domain-containing protein 9 | UniProt NCBI |
| COMMD4 | COMM domain-containing protein 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6645 | 7.93136120433e-30 | 0.833333333333 | COMMD7 COMMD3 VPS35L CCDC22 COMMD9 COMMD10 COMMD4 COMMD2 COMMD6 COMMD5 | CCC complex |
| CORUM:6639 | 8.32589433107e-29 | 0.833333333333 | COMMD7 COMMD3 VPS35L CCDC22 COMMD9 COMMD10 COMMD4 COMMD2 COMMD6 COMMD5 | CCC-Wash (WASH1, FAM21C) complex |
| REAC:R-HSA-8951664 | 1.57876358322e-12 | 0.75 | COMMD7 COMMD3 CCDC22 COMMD6 COMMD10 COMMD5 COMMD2 COMMD9 COMMD4 | Neddylation |
| REAC:R-HSA-597592 | 9.01251590827e-06 | 0.75 | COMMD7 COMMD3 CCDC22 COMMD6 COMMD10 COMMD5 COMMD2 COMMD9 COMMD4 | Post-translational protein modification |
| CORUM:7132 | 0.000110698604565 | 0.166666666667 | VPS35L CCDC22 | CCDC22-CCDC93-C16orf62 complex |
| REAC:R-HSA-392499 | 0.000212678742663 | 0.75 | COMMD7 COMMD3 CCDC22 COMMD6 COMMD10 COMMD5 COMMD2 COMMD9 COMMD4 | Metabolism of proteins |
| CORUM:7131 | 0.00022129809732 | 0.166666666667 | VPS35L CCDC22 | COMMD1-CCDC22-CCDC93-C16orf62 complex |
| CORUM:7135 | 0.000368665050728 | 0.166666666667 | VPS35L CCDC22 | CCDC22-CCDC93-C16orf62-FAM21-WASH1 complex |
| CORUM:0000000 | 0.00103875568224 | 0.833333333333 | COMMD7 COMMD3 VPS35L CCDC22 COMMD9 COMMD10 COMMD4 COMMD2 COMMD6 COMMD5 | CORUM root |
| GO:1990126 | 0.0454979856024 | 0.25 | VPS35L VPS26C CCDC22 | retrograde transport, endosome to plasma membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COMMD3 | CCDC22 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22,COMMD3) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| CCDC22 | COMMD2 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22,COMMD2) bioplex_WMM Guru youn_WMM hein (CCDC22) gupta_WMM fraction |
| COMMD4 | CCDC22 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22,COMMD4) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| DENND10 | COMMD3 | 1.0 | 0.949 | hein_WMM bioplex (COMMD3,DENND10) bioplex_WMM |
| VPS35L | CCDC22 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| VPS35L | COMMD3 | 1.0 | 0.949 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| COMMD5 | COMMD3 | 0.999 | 0.949 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| COMMD10 | CCDC22 | 0.999 | 0.949 | hein_WMM bioplex (CCDC22,COMMD10) bioplex_WMM Guru hein (CCDC22) fraction |
| COMMD4 | COMMD3 | 0.999 | 0.948 | hein_WMM bioplex (COMMD3,COMMD4) bioplex_WMM youn_WMM gupta_WMM |
| COMMD3 | COMMD2 | 0.997 | 0.932 | hein_WMM bioplex (COMMD2,COMMD3) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD6 | CCDC22 | 0.993 | 0.918 | hein_WMM bioplex (CCDC22,COMMD6) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| COMMD7 | CCDC22 | 0.988 | 0.902 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| COMMD4 | COMMD7 | 0.987 | 0.901 | hein_WMM bioplex (COMMD4) bioplex_WMM fraction |
| COMMD10 | COMMD4 | 0.987 | 0.901 | hein_WMM bioplex (COMMD10,COMMD4) bioplex_WMM fraction |
| COMMD4 | COMMD2 | 0.986 | 0.9 | hein_WMM bioplex (COMMD2,COMMD4) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD4 | COMMD9 | 0.983 | 0.899 | hein_WMM bioplex (COMMD4) bioplex_WMM |
| DENND10 | COMMD4 | 0.982 | 0.898 | hein_WMM bioplex (COMMD4,DENND10) bioplex_WMM fraction |
| COMMD5 | CCDC22 | 0.978 | 0.894 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| COMMD10 | COMMD3 | 0.939 | 0.851 | hein_WMM bioplex (COMMD10,COMMD3) bioplex_WMM fraction |
| COMMD9 | COMMD3 | 0.903 | 0.827 | hein_WMM bioplex (COMMD3) bioplex_WMM fraction |
| COMMD9 | CCDC22 | 0.901 | 0.826 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| VPS26C | COMMD3 | 0.889 | 0.818 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| COMMD6 | VPS35L | 0.86 | 0.796 | hein_WMM bioplex (COMMD6) bioplex_WMM |
| COMMD6 | COMMD4 | 0.847 | 0.79 | hein_WMM bioplex (COMMD4,COMMD6) bioplex_WMM gupta_WMM |
| COMMD7 | COMMD3 | 0.817 | 0.773 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| VPS26C | CCDC22 | 0.75 | 0.743 | hein_WMM bioplex_WMM hein (CCDC22) fraction |
| COMMD6 | COMMD5 | 0.722 | 0.732 | hein_WMM bioplex (COMMD6) bioplex_WMM |
| VPS35L | COMMD4 | 0.713 | 0.728 | hein_WMM bioplex (COMMD4) bioplex_WMM fraction |
| COMMD7 | COMMD2 | 0.673 | 0.706 | hein_WMM bioplex (COMMD2) bioplex_WMM fraction |
| COMMD4 | COMMD5 | 0.645 | 0.687 | hein_WMM bioplex (COMMD4) bioplex_WMM fraction |
| COMMD10 | COMMD7 | 0.631 | 0.681 | hein_WMM bioplex (COMMD10) bioplex_WMM |
| COMMD10 | COMMD9 | 0.608 | 0.674 | hein_WMM bioplex (COMMD10) bioplex_WMM |
| DENND10 | CCDC22 | 0.515 | 0.632 | hein_WMM bioplex (CCDC22,DENND10) bioplex_WMM hein (CCDC22) fraction |
| VPS35L | COMMD2 | 0.508 | 0.628 | hein_WMM bioplex (COMMD2) bioplex_WMM fraction |
| DENND10 | COMMD7 | 0.479 | 0.612 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| COMMD10 | COMMD6 | 0.476 | 0.609 | hein_WMM bioplex (COMMD10,COMMD6) bioplex_WMM |
| DENND10 | COMMD9 | 0.443 | 0.586 | hein_WMM bioplex (DENND10) bioplex_WMM |
| COMMD6 | COMMD2 | 0.415 | 0.572 | hein_WMM bioplex (COMMD2,COMMD6) bioplex_WMM youn_WMM gupta_WMM |
| COMMD9 | COMMD2 | 0.415 | 0.571 | hein_WMM bioplex (COMMD2) bioplex_WMM |
| COMMD6 | COMMD3 | 0.402 | 0.561 | hein_WMM bioplex (COMMD3,COMMD6) bioplex_WMM gupta_WMM fraction |
| COMMD5 | COMMD2 | 0.383 | 0.551 | hein_WMM bioplex (COMMD2) bioplex_WMM fraction |
| COMMD10 | COMMD2 | 0.348 | 0.536 | hein_WMM bioplex (COMMD10,COMMD2) bioplex_WMM Guru fraction |
| COMMD6 | VPS26C | 0.327 | 0.516 | hein_WMM bioplex (COMMD6) bioplex_WMM |
| DENND10 | COMMD6 | 0.31 | 0.503 | hein_WMM bioplex (COMMD6,DENND10) bioplex_WMM |
| COMMD6 | COMMD9 | 0.307 | 0.502 | hein_WMM bioplex (COMMD6) bioplex_WMM fraction |
| COMMD6 | COMMD7 | 0.291 | 0.492 | hein_WMM bioplex (COMMD6) bioplex_WMM |
| COMMD10 | VPS35L | 0.153 | 0.411 | hein_WMM bioplex (COMMD10) bioplex_WMM fraction |
| DENND10 | COMMD10 | 0.125 | 0.399 | hein_WMM bioplex (COMMD10,DENND10) bioplex_WMM fraction |
| DENND10 | VPS26C | 0.113 | 0.38 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| COMMD7 | COMMD5 | 0.101 | 0.364 | hein_WMM bioplex_WMM fraction |
| DENND10 | COMMD2 | 0.079 | 0.352 | hein_WMM bioplex (COMMD2,DENND10) bioplex_WMM fraction |
| VPS35L | COMMD7 | 0.072 | 0.353 | hein_WMM bioplex_WMM fraction |
| COMMD5 | COMMD9 | 0.059 | 0.328 | hein_WMM bioplex_WMM WMM_only |
| COMMD10 | COMMD5 | 0.058 | 0.325 | hein_WMM bioplex (COMMD10) bioplex_WMM fraction |
| VPS35L | COMMD9 | 0.057 | 0.324 | hein_WMM bioplex_WMM WMM_only |
| DENND10 | VPS35L | 0.054 | 0.303 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| COMMD7 | COMMD9 | 0.047 | 0.293 | hein_WMM bioplex_WMM WMM_only |
| DENND10 | COMMD5 | 0.039 | 0.266 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| VPS26C | COMMD9 | 0.034 | 0.261 | hein_WMM bioplex_WMM WMM_only |
| VPS26C | COMMD7 | 0.011 | 0.141 | hein_WMM bioplex_WMM fraction |
| VPS35L | COMMD5 | 0.005 | 0.014 | hein_WMM bioplex_WMM fraction |
| COMMD10 | VPS26C | 0.004 | 0.007 | hein_WMM bioplex (COMMD10) bioplex_WMM fraction |
| VPS26C | COMMD2 | 0.003 | 0.014 | hein_WMM bioplex_WMM youn_WMM fraction |
| VPS26C | COMMD4 | 0.0 | 0.015 | hein_WMM bioplex (COMMD4) bioplex_WMM gupta_WMM fraction |
| VPS26C | VPS35L | 0.0 | 0.001 | hein_WMM bioplex_WMM fraction |
| VPS26C | COMMD5 | 0.0 | 0.0 | hein_WMM bioplex_WMM fraction |
Images
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Complex HuMAP2_00912 has an average edge precision of 0.602 which is ranked 1933 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VPS26C | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 HuMAP2_06842 |
| COMMD10 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| VPS35L | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| COMMD3 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_05140 HuMAP2_06442 |
| CCDC22 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_05140 HuMAP2_06442 |
| COMMD2 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| COMMD6 | HuMAP2_00773 HuMAP2_00912 HuMAP2_06442 |
| COMMD7 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| DENND10 | HuMAP2_00458 HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| COMMD5 | HuMAP2_00773 HuMAP2_00912 HuMAP2_06442 |
| COMMD9 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| COMMD4 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |