hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00917
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MT-ND5 | NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) (NADH dehydrogenase subunit 5) | UniProt NCBI |
| ITM2A | Integral membrane protein 2A (Protein E25) | UniProt NCBI |
| NDUFB3 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (CI-B12) (NADH-ubiquinone oxidoreductase B12 subunit) | UniProt NCBI |
| NDUFB5 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2914 | 3.07044439662e-07 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Respiratory chain complex I (beta subunit) mitochondrial |
| WP:WP4324 | 5.27244283038e-06 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Mitochondrial complex I assembly model OXPHOS system |
| CORUM:178 | 6.65885054531e-06 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Respiratory chain complex I (holoenzyme), mitochondrial |
| WP:WP111 | 2.91471848583e-05 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Electron Transport Chain (OXPHOS system in mitochondria) |
| REAC:R-HSA-6799198 | 2.97715563398e-05 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Complex I biogenesis |
| KEGG:00190 | 7.14089641582e-05 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Oxidative phosphorylation |
| KEGG:05012 | 8.70468528245e-05 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Parkinson disease |
| KEGG:04723 | 0.000100163001336 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-611105 | 0.000180191665247 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Respiratory electron transport |
| REAC:R-HSA-163200 | 0.000340340039133 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:04714 | 0.000399392690129 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | Thermogenesis |
| REAC:R-HSA-1428517 | 0.000984664941346 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | The citric acid (TCA) cycle and respiratory electron transport |
| WP:WP623 | 0.00248310593375 | 0.5 | NDUFB5 MT-ND5 | Oxidative phosphorylation |
| GO:0050136 | 0.00305917975424 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | NADH dehydrogenase (quinone) activity |
| GO:0008137 | 0.00305917975424 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | NADH dehydrogenase (ubiquinone) activity |
| GO:0003954 | 0.00305917975424 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | NADH dehydrogenase activity |
| GO:0030964 | 0.00480126971785 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | NADH dehydrogenase complex |
| GO:0005747 | 0.00480126971785 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | mitochondrial respiratory chain complex I |
| GO:0045271 | 0.00480126971785 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | respiratory chain complex I |
| GO:0006120 | 0.00514395792508 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | mitochondrial electron transport, NADH to ubiquinone |
| GO:0016655 | 0.0080085486554 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| GO:0010257 | 0.0130360493673 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | NADH dehydrogenase complex assembly |
| GO:0032981 | 0.0130360493673 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | mitochondrial respiratory chain complex I assembly |
| WP:WP4396 | 0.0154631487697 | 0.5 | NDUFB5 NDUFB3 | Nonalcoholic fatty liver disease |
| KEGG:04932 | 0.0173825101547 | 0.5 | NDUFB5 NDUFB3 | Non-alcoholic fatty liver disease (NAFLD) |
| GO:0098803 | 0.0181462528862 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | respiratory chain complex |
| GO:0005746 | 0.0189701239271 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | mitochondrial respirasome |
| GO:0070469 | 0.0225145500348 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | respirasome |
| KEGG:05010 | 0.0232850911193 | 0.5 | NDUFB5 NDUFB3 | Alzheimer disease |
| GO:0042775 | 0.0275320606423 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.0286174056273 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | ATP synthesis coupled electron transport |
| HP:0001138 | 0.0300060012618 | 0.5 | MT-ND5 NDUFB3 | Optic neuropathy |
| HP:0003737 | 0.0300060012618 | 0.5 | MT-ND5 NDUFB3 | Mitochondrial myopathy |
| KEGG:05016 | 0.03037774612 | 0.5 | NDUFB5 NDUFB3 | Huntington disease |
| GO:0016651 | 0.037022076332 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | oxidoreductase activity, acting on NAD(P)H |
| GO:1990204 | 0.0396936057372 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | oxidoreductase complex |
| GO:0033108 | 0.0424904593616 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | mitochondrial respiratory chain complex assembly |
| GO:0022904 | 0.0439367749778 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | respiratory electron transport chain |
| GO:0022900 | 0.0454154921687 | 0.75 | NDUFB5 MT-ND5 NDUFB3 | electron transport chain |
| HP:0003800 | 0.0470133620262 | 0.5 | MT-ND5 NDUFB3 | Muscle abnormality related to mitochondrial dysfunction |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFB5 | NDUFB3 | 0.1 | 0.362 | bioplex (NDUFB5) bioplex_WMM |
| MT-ND5 | NDUFB5 | 0.087 | 0.352 | bioplex (NDUFB5) bioplex_WMM |
| MT-ND5 | NDUFB3 | 0.023 | 0.207 | bioplex_WMM WMM_only |
| NDUFB5 | ITM2A | 0.021 | 0.191 | bioplex (ITM2A) bioplex_WMM |
Images
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Complex HuMAP2_00917 has an average edge precision of 0.278 which is ranked 4909 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MT-ND5 | HuMAP2_00273 HuMAP2_00917 HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_02247 |
| ITM2A | HuMAP2_00306 HuMAP2_00917 HuMAP2_06394 |
| NDUFB3 | HuMAP2_00917 HuMAP2_01573 HuMAP2_01600 HuMAP2_04543 |
| NDUFB5 | HuMAP2_00306 HuMAP2_00917 HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_02247 HuMAP2_04543 |