hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00924
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RABL6 | Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) | UniProt NCBI |
| EDA | Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form] | UniProt NCBI |
| AP3S1 | AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) | UniProt NCBI |
| AP3D1 | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | UniProt NCBI |
| RNF167 | E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) (RING-type E3 ubiquitin transferase RNF167) (RING105) | UniProt NCBI |
| AP3B1 | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | UniProt NCBI |
| AP3M1 | AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) | UniProt NCBI |
| AP3M2 | AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) | UniProt NCBI |
| AP3B2 | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:59 | 1.60394245013e-18 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | AP3 adaptor complex |
| CORUM:652 | 1.14523480446e-15 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | AP3-BLOC1 complex |
| GO:0099514 | 3.42535836404e-12 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | synaptic vesicle cytoskeletal transport |
| GO:0099517 | 3.42535836404e-12 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | synaptic vesicle transport along microtubule |
| GO:0048490 | 3.42535836404e-12 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | anterograde synaptic vesicle transport |
| GO:0048489 | 3.71142228382e-10 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | synaptic vesicle transport |
| GO:0047496 | 7.61315645071e-10 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | vesicle transport along microtubule |
| GO:0008089 | 7.61315645071e-10 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | anterograde axonal transport |
| KEGG:04142 | 9.17282955512e-10 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | Lysosome |
| GO:0097479 | 1.05814745686e-09 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | synaptic vesicle localization |
| GO:0099518 | 2.24345147816e-09 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | vesicle cytoskeletal trafficking |
| GO:0098930 | 2.57952263146e-09 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | axonal transport |
| GO:0008088 | 4.95532278155e-09 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | axo-dendritic transport |
| GO:0072384 | 2.05828779234e-08 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | organelle transport along microtubule |
| GO:0010970 | 1.54406646474e-06 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | transport along microtubule |
| GO:0099111 | 3.01700330972e-06 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | microtubule-based transport |
| GO:0030705 | 4.19082204754e-06 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | cytoskeleton-dependent intracellular transport |
| GO:0051650 | 5.30143542207e-06 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | establishment of vesicle localization |
| GO:0051648 | 7.15364419356e-06 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | vesicle localization |
| CORUM:2308 | 1.34129279418e-05 | 0.222222222222 | AP3S1 AP3D1 | AP3D1-AP3S1 complex |
| GO:0007018 | 5.40981848663e-05 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | microtubule-based movement |
| GO:0051656 | 0.000327131288655 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | establishment of organelle localization |
| GO:0051640 | 0.00469219807311 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | organelle localization |
| GO:0007017 | 0.0202910814678 | 0.666666666667 | AP3S1 AP3B1 AP3M1 AP3B2 AP3M2 AP3D1 | microtubule-based process |
| GO:0030119 | 0.027657204222 | 0.333333333333 | AP3S1 AP3D1 AP3M2 | AP-type membrane coat adaptor complex |
| HP:0001107 | 0.0425872663121 | 0.222222222222 | AP3D1 AP3B1 | Ocular albinism |
| CORUM:2307 | 0.0499262710315 | 0.111111111111 | AP3D1 | AP3D1-AP3S2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AP3D1 | AP3B1 | 1.0 | 0.949 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP3S1 | AP3D1 | 0.994 | 0.919 | bioplex (AP3S1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3S1 | AP3B1 | 0.988 | 0.901 | bioplex (AP3S1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3D1 | AP3M1 | 0.988 | 0.901 | bioplex (AP3M1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3S1 | AP3M1 | 0.988 | 0.901 | bioplex (AP3M1,AP3S1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3M1 | AP3B1 | 0.988 | 0.901 | bioplex (AP3M1) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| AP3S1 | AP3B2 | 0.967 | 0.877 | bioplex (AP3S1) bioplex_WMM youn_WMM |
| AP3M1 | AP3B2 | 0.922 | 0.843 | bioplex (AP3M1) bioplex_WMM youn_WMM |
| AP3S1 | AP3M2 | 0.792 | 0.758 | bioplex (AP3M2,AP3S1) bioplex_WMM youn_WMM fraction |
| AP3S1 | RABL6 | 0.448 | 0.592 | hein_WMM bioplex (AP3S1) bioplex_WMM youn_WMM gupta_WMM |
| AP3B1 | AP3M2 | 0.253 | 0.477 | bioplex (AP3M2) bioplex_WMM youn_WMM fraction |
| EDA | AP3B1 | 0.107 | 0.372 | bioplex (EDA) bioplex_WMM |
| AP3M1 | AP3M2 | 0.1 | 0.361 | bioplex (AP3M1) bioplex_WMM youn_WMM |
| AP3D1 | AP3M2 | 0.098 | 0.357 | bioplex (AP3M2) bioplex_WMM youn_WMM fraction |
| AP3M1 | RABL6 | 0.083 | 0.351 | bioplex (AP3M1) bioplex_WMM youn_WMM gupta_WMM |
| EDA | AP3B2 | 0.053 | 0.301 | bioplex (EDA) bioplex_WMM |
| EDA | AP3M2 | 0.047 | 0.291 | bioplex (EDA) bioplex_WMM |
| AP3S1 | RNF167 | 0.04 | 0.268 | bioplex (AP3S1) bioplex_WMM |
| AP3M2 | AP3B2 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| AP3B1 | AP3B2 | 0.011 | 0.141 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RABL6 | AP3B2 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| AP3D1 | AP3B2 | 0.009 | 0.103 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP3D1 | RABL6 | 0.009 | 0.105 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RABL6 | AP3M2 | 0.009 | 0.097 | bioplex_WMM youn_WMM WMM_only |
| RABL6 | AP3B1 | 0.008 | 0.087 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP3D1 | RNF167 | 0.008 | 0.055 | bioplex_WMM WMM_only |
| RNF167 | AP3B2 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| AP3M1 | EDA | 0.007 | 0.013 | bioplex (EDA) bioplex_WMM |
| RABL6 | RNF167 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RNF167 | AP3M2 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| RNF167 | AP3B1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| AP3M1 | RNF167 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00924 has an average edge precision of 0.382 which is ranked 3509 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RABL6 | HuMAP2_00924 HuMAP2_02783 HuMAP2_06447 |
| EDA | HuMAP2_00924 HuMAP2_01887 |
| AP3S1 | HuMAP2_00924 HuMAP2_02783 HuMAP2_05936 HuMAP2_06447 |
| AP3D1 | HuMAP2_00924 HuMAP2_05936 HuMAP2_06447 |
| RNF167 | HuMAP2_00924 HuMAP2_02783 HuMAP2_06447 |
| AP3B1 | HuMAP2_00924 HuMAP2_05936 HuMAP2_06447 |
| AP3M1 | HuMAP2_00924 HuMAP2_02783 HuMAP2_05936 HuMAP2_06447 |
| AP3M2 | HuMAP2_00924 HuMAP2_05936 HuMAP2_06447 |
| AP3B2 | HuMAP2_00924 HuMAP2_01887 HuMAP2_02783 HuMAP2_05936 HuMAP2_06447 |