hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00926
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RGPD5 | RANBP2-like and GRIP domain-containing protein 5/6 (Ran-binding protein 2-like 1/2) (RanBP2-like 1/2) (RanBP2L1) (RanBP2L2) (Sperm membrane protein BS-63) | UniProt NCBI |
| UBE2I | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | UniProt NCBI |
| RANGAP1 | Ran GTPase-activating protein 1 (RanGAP1) | UniProt NCBI |
| RANBP2 | E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270) | UniProt NCBI |
| RCC1 | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-165054 | 6.06176646053e-06 | 0.75 | RANBP2 RCC1 RANGAP1 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-177243 | 7.35698811902e-06 | 0.75 | RANBP2 RCC1 RANGAP1 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-4615885 | 1.54728521392e-05 | 0.75 | RANBP2 RANGAP1 UBE2I | SUMOylation of DNA replication proteins |
| KEGG:03013 | 0.000156303289806 | 0.75 | RANBP2 RANGAP1 UBE2I | RNA transport |
| REAC:R-HSA-162909 | 0.000396320737366 | 0.75 | RANBP2 RCC1 RANGAP1 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.000514250934249 | 0.75 | RANBP2 RCC1 RANGAP1 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 0.000681200950707 | 0.75 | RANBP2 RCC1 RANGAP1 | HIV Life Cycle |
| GO:0008536 | 0.000834605087859 | 0.75 | RANBP2 RCC1 RANGAP1 | Ran GTPase binding |
| REAC:R-HSA-3108232 | 0.0010027366871 | 0.75 | RANBP2 RANGAP1 UBE2I | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.00111581489513 | 0.75 | RANBP2 RANGAP1 UBE2I | SUMOylation |
| REAC:R-HSA-162906 | 0.00243524237836 | 0.75 | RANBP2 RCC1 RANGAP1 | HIV Infection |
| REAC:R-HSA-180746 | 0.00436320194063 | 0.5 | RANBP2 RCC1 | Nuclear import of Rev protein |
| REAC:R-HSA-4085377 | 0.00466369436644 | 0.5 | RANBP2 UBE2I | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-3232142 | 0.00562500866147 | 0.5 | RANBP2 UBE2I | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-4570464 | 0.00862684444961 | 0.5 | RANBP2 UBE2I | SUMOylation of RNA binding proteins |
| GO:0005635 | 0.0096936769593 | 1.0 | RANBP2 RANGAP1 RCC1 UBE2I | nuclear envelope |
| REAC:R-HSA-5663205 | 0.0100576606226 | 0.75 | RANBP2 RCC1 RANGAP1 | Infectious disease |
| GO:0016925 | 0.0189701239271 | 0.75 | RANBP2 RANGAP1 UBE2I | protein sumoylation |
| REAC:R-HSA-4551638 | 0.0207977326435 | 0.5 | RANBP2 UBE2I | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 0.0248339118539 | 0.5 | RANBP2 UBE2I | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-141424 | 0.041754071825 | 0.5 | RANBP2 RANGAP1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.041754071825 | 0.5 | RANBP2 RANGAP1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RANGAP1 | RANBP2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru hein (RANBP2) Malo gupta_WMM fraction treiber_WMM |
| RCC1 | RANGAP1 | 0.999 | 0.949 | hein_WMM bioplex (RCC1) bioplex_WMM hein (RCC1) gupta_WMM treiber_WMM |
| RCC1 | RANBP2 | 0.996 | 0.928 | hein_WMM bioplex (RCC1) bioplex_WMM hein (RANBP2,RCC1) gupta_WMM |
| RCC1 | UBE2I | 0.995 | 0.924 | hein_WMM bioplex (RCC1,UBE2I) bioplex_WMM youn_WMM hein (RCC1,UBE2I) gupta_WMM |
| RGPD5 | RANGAP1 | 0.984 | 0.899 | hein_WMM Guru Malo gupta_WMM fraction |
| RANGAP1 | UBE2I | 0.89 | 0.818 | hein_WMM bioplex (UBE2I) bioplex_WMM hein (UBE2I) gupta_WMM |
| RANBP2 | UBE2I | 0.568 | 0.655 | hein_WMM bioplex (UBE2I) bioplex_WMM hein (RANBP2,UBE2I) gupta_WMM |
| RGPD5 | UBE2I | 0.009 | 0.092 | hein_WMM youn_WMM gupta_WMM WMM_only |
| RCC1 | RGPD5 | 0.009 | 0.098 | hein_WMM youn_WMM gupta_WMM WMM_only |
| RGPD5 | RANBP2 | 0.0 | 0.0 | hein_WMM hein (RANBP2) gupta_WMM |
Images
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Complex HuMAP2_00926 has an average edge precision of 0.631 which is ranked 1776 out of all 6965 complexes.
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