hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00949
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CTSA | Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] | UniProt NCBI |
| GLB1 | Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) (Elastin receptor 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0008166 | 3.33943267688e-06 | 1.0 | CTSA GLB1 | Decreased beta-galactosidase activity |
| HP:0003649 | 3.33943267688e-06 | 1.0 | CTSA GLB1 | Abnormality of glycoside metabolism |
| HP:0004342 | 3.33943267688e-06 | 1.0 | CTSA GLB1 | Abnormality of galactoside metabolism |
| REAC:R-HSA-4341670 | 5.02777038712e-06 | 1.0 | CTSA GLB1 | Defective NEU1 causes sialidosis |
| CORUM:1379 | 1.00555407742e-05 | 1.0 | CTSA GLB1 | GALNS-lysosomal hydrolase 1.27 MDa complex |
| HP:0010729 | 0.000120219576368 | 1.0 | CTSA GLB1 | Cherry red spot of the macula |
| REAC:R-HSA-5609975 | 0.000201110815485 | 1.0 | CTSA GLB1 | Diseases associated with glycosylation precursor biosynthesis |
| REAC:R-HSA-4085001 | 0.000729026706133 | 1.0 | CTSA GLB1 | Sialic acid metabolism |
| KEGG:04142 | 0.00100713074717 | 1.0 | CTSA GLB1 | Lysosome |
| REAC:R-HSA-1660662 | 0.00130722030065 | 1.0 | CTSA GLB1 | Glycosphingolipid metabolism |
| REAC:R-HSA-446219 | 0.00277030148331 | 1.0 | CTSA GLB1 | Synthesis of substrates in N-glycan biosythesis |
| HP:0000630 | 0.00315910331233 | 1.0 | CTSA GLB1 | Abnormal retinal artery morphology |
| REAC:R-HSA-446193 | 0.00440432685912 | 1.0 | CTSA GLB1 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| REAC:R-HSA-428157 | 0.00452666927187 | 1.0 | CTSA GLB1 | Sphingolipid metabolism |
| HP:3000036 | 0.00514272632239 | 1.0 | CTSA GLB1 | Abnormality of head blood vessel |
| HP:0007759 | 0.00694601996791 | 1.0 | CTSA GLB1 | Opacification of the corneal stroma |
| HP:0011492 | 0.00760722763793 | 1.0 | CTSA GLB1 | Abnormality of corneal stroma |
| WP:WP4352 | 0.0083331540652 | 1.0 | CTSA GLB1 | Ciliary landscape |
| HP:0003510 | 0.00977118001255 | 1.0 | CTSA GLB1 | Severe short stature |
| REAC:R-HSA-3781865 | 0.0125744537382 | 1.0 | CTSA GLB1 | Diseases of glycosylation |
| HP:0003508 | 0.0168641350182 | 1.0 | CTSA GLB1 | Proportionate short stature |
| REAC:R-HSA-2206308 | 0.0249595281251 | 0.5 | GLB1 | MPS IV - Morquio syndrome B |
| KEGG:00604 | 0.0304066530708 | 0.5 | GLB1 | Glycosphingolipid biosynthesis - ganglio series |
| KEGG:00531 | 0.0369186440558 | 0.5 | GLB1 | Glycosaminoglycan degradation |
| KEGG:00511 | 0.0390890159223 | 0.5 | GLB1 | Other glycan degradation |
| KEGG:04614 | 0.0412592418913 | 0.5 | CTSA | Renin-angiotensin system |
| HP:0008046 | 0.0440905296328 | 1.0 | CTSA GLB1 | Abnormal retinal vascular morphology |
| HP:0012379 | 0.0457335305099 | 1.0 | CTSA GLB1 | Abnormal enzyme/coenzyme activity |
| HP:0000280 | 0.0462878763342 | 1.0 | CTSA GLB1 | Coarse facial features |
| HP:0005292 | 0.0497341708567 | 0.5 | GLB1 | Intimal thickening in the coronary arteries |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GLB1 | CTSA | 0.845 | 0.788 | bioplex (GLB1) bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_00949 has an average edge precision of 0.788 which is ranked 971 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CTSA | HuMAP2_00949 HuMAP2_01586 HuMAP2_06665 |
| GLB1 | HuMAP2_00918 HuMAP2_00949 HuMAP2_06665 |