hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00969
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SBF2 | Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2) | UniProt NCBI |
| MTMR2 | Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1660499 | 0.00189044166556 | 1.0 | SBF2 MTMR2 | Synthesis of PIPs at the plasma membrane |
| HP:0003431 | 0.0022240621628 | 1.0 | SBF2 MTMR2 | Decreased motor nerve conduction velocity |
| HP:0040131 | 0.00260475748797 | 1.0 | SBF2 MTMR2 | Abnormal motor nerve conduction velocity |
| REAC:R-HSA-1483255 | 0.00503279815751 | 1.0 | SBF2 MTMR2 | PI Metabolism |
| HP:0003130 | 0.0116412623116 | 1.0 | SBF2 MTMR2 | Abnormal peripheral myelination |
| HP:0000762 | 0.012205626434 | 1.0 | SBF2 MTMR2 | Decreased nerve conduction velocity |
| HP:0002936 | 0.0127833482871 | 1.0 | SBF2 MTMR2 | Distal sensory impairment |
| HP:0040129 | 0.0133744278709 | 1.0 | SBF2 MTMR2 | Abnormal nerve conduction velocity |
| HP:0003134 | 0.0158723235132 | 1.0 | SBF2 MTMR2 | Abnormality of peripheral nerve conduction |
| HP:0045010 | 0.0168641350182 | 1.0 | SBF2 MTMR2 | Abnormality of peripheral nerves |
| HP:0030177 | 0.019295242007 | 1.0 | SBF2 MTMR2 | Abnormality of peripheral nervous system electrophysiology |
| HP:0003693 | 0.0230521037685 | 1.0 | SBF2 MTMR2 | Distal amyotrophy |
| REAC:R-HSA-1483257 | 0.0282158474125 | 1.0 | SBF2 MTMR2 | Phospholipid metabolism |
| HP:0002460 | 0.0315676570945 | 1.0 | SBF2 MTMR2 | Distal muscle weakness |
| HP:0007208 | 0.0497341708567 | 0.5 | MTMR2 | Irregular myelin loops |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SBF2 | MTMR2 | 0.045 | 0.287 | hein_WMM hein (MTMR2) |
Images
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Complex HuMAP2_00969 has an average edge precision of 0.287 which is ranked 4787 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SBF2 | HuMAP2_00969 HuMAP2_06845 |
| MTMR2 | HuMAP2_00969 HuMAP2_03509 HuMAP2_06845 |