hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00971
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DOCK3 | Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) | UniProt NCBI |
| ELMO2 | Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) | UniProt NCBI |
| DOCK4 | Dedicator of cytokinesis protein 4 | UniProt NCBI |
| ELMO1 | Engulfment and cell motility protein 1 (Protein ced-12 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8849471 | 0.000783559910601 | 0.5 | ELMO2 ELMO1 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| KEGG:05131 | 0.00401698930658 | 0.5 | ELMO2 ELMO1 | Shigellosis |
| KEGG:05100 | 0.00523220354961 | 0.5 | ELMO2 ELMO1 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-9006927 | 0.0103665290697 | 0.5 | ELMO2 ELMO1 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 0.0103665290697 | 0.5 | ELMO2 ELMO1 | Signaling by PTK6 |
| REAC:R-HSA-9006934 | 0.0147563350021 | 0.75 | DOCK3 ELMO1 ELMO2 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-2029482 | 0.017117349746 | 0.5 | ELMO2 ELMO1 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-2029480 | 0.0315540312145 | 0.5 | ELMO2 ELMO1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-4420097 | 0.0408500448467 | 0.5 | ELMO2 ELMO1 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.0483568152087 | 0.5 | ELMO2 ELMO1 | Signaling by VEGF |
| CORUM:5337 | 0.0499140284799 | 0.25 | ELMO1 | ELMO1-DOCK1 complex |
| CORUM:5341 | 0.0499140284799 | 0.25 | ELMO1 | ELMO1-DOCK2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DOCK3 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| DOCK4 | ELMO1 | 1.0 | 0.949 | bioplex (ELMO1) bioplex_WMM |
| ELMO2 | ELMO1 | 0.99 | 0.909 | bioplex (ELMO1) bioplex_WMM |
| DOCK4 | ELMO2 | 0.012 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| DOCK4 | DOCK3 | 0.011 | 0.146 | bioplex_WMM WMM_only |
| DOCK3 | ELMO2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00971 has an average edge precision of 0.541 which is ranked 2264 out of all 6965 complexes.
Related Complexes