hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00976
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TM9SF3 | Transmembrane 9 superfamily member 3 (EP70-P-iso) (SM-11044-binding protein) | UniProt NCBI |
| AGO1 | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | UniProt NCBI |
| XPO1 | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | UniProt NCBI |
| TNRC6C | Trinucleotide repeat-containing gene 6C protein | UniProt NCBI |
| AGO2 | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 9.51308232652e-08 | 0.6 | AGO2 AGO1 TNRC6C | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 1.52193981994e-07 | 0.6 | AGO2 AGO1 TNRC6C | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-8943723 | 2.28267971382e-07 | 0.6 | AGO2 AGO1 TNRC6C | Regulation of PTEN mRNA translation |
| REAC:R-HSA-5687128 | 8.09278526697e-07 | 0.8 | AGO2 TNRC6C AGO1 XPO1 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-8934593 | 1.84639431008e-06 | 0.6 | AGO2 AGO1 TNRC6C | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-9022692 | 9.90965664735e-06 | 0.6 | AGO2 AGO1 TNRC6C | Regulation of MECP2 expression and activity |
| REAC:R-HSA-8939211 | 2.53107371053e-05 | 0.8 | AGO2 TNRC6C AGO1 XPO1 | ESR-mediated signaling |
| REAC:R-HSA-5683057 | 4.54388535997e-05 | 0.8 | AGO2 TNRC6C AGO1 XPO1 | MAPK family signaling cascades |
| REAC:R-HSA-9006931 | 5.19415811062e-05 | 0.8 | AGO2 TNRC6C AGO1 XPO1 | Signaling by Nuclear Receptors |
| REAC:R-HSA-4086398 | 6.33776832781e-05 | 0.6 | AGO2 AGO1 TNRC6C | Ca2+ pathway |
| REAC:R-HSA-8986944 | 6.33776832781e-05 | 0.6 | AGO2 AGO1 TNRC6C | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-195721 | 0.000135560445088 | 0.8 | AGO2 TNRC6C AGO1 XPO1 | Signaling by WNT |
| REAC:R-HSA-5628897 | 0.000221673564929 | 0.6 | AGO2 AGO1 TNRC6C | TP53 Regulates Metabolic Genes |
| GO:0045974 | 0.000259479548289 | 0.6 | AGO2 AGO1 TNRC6C | regulation of translation, ncRNA-mediated |
| GO:0040033 | 0.000259479548289 | 0.6 | AGO2 AGO1 TNRC6C | negative regulation of translation, ncRNA-mediated |
| GO:0035278 | 0.000259479548289 | 0.6 | AGO2 AGO1 TNRC6C | miRNA mediated inhibition of translation |
| MIRNA:hsa-miR-4666a-5p | 0.000314344166806 | 0.6 | TM9SF3 TNRC6C AGO2 | hsa-miR-4666a-5p |
| REAC:R-HSA-1912408 | 0.000327410819085 | 0.6 | AGO2 AGO1 TNRC6C | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-426486 | 0.000485460775426 | 0.4 | AGO2 AGO1 | Small interfering RNA (siRNA) biogenesis |
| REAC:R-HSA-1912422 | 0.000534065976599 | 0.6 | AGO2 AGO1 TNRC6C | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-211000 | 0.00100555265154 | 0.6 | AGO2 AGO1 TNRC6C | Gene Silencing by RNA |
| REAC:R-HSA-6807070 | 0.00107590614735 | 0.6 | AGO2 AGO1 TNRC6C | PTEN Regulation |
| REAC:R-HSA-3858494 | 0.00112457746833 | 0.6 | AGO2 AGO1 TNRC6C | Beta-catenin independent WNT signaling |
| REAC:R-HSA-9018519 | 0.00122625830858 | 0.6 | AGO2 AGO1 TNRC6C | Estrogen-dependent gene expression |
| REAC:R-HSA-203927 | 0.00371437175588 | 0.4 | AGO2 AGO1 | MicroRNA (miRNA) biogenesis |
| REAC:R-HSA-8878171 | 0.00459345384685 | 0.6 | AGO2 AGO1 TNRC6C | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-157118 | 0.0046564839046 | 0.6 | AGO2 AGO1 TNRC6C | Signaling by NOTCH |
| GO:0007223 | 0.0049400991777 | 0.6 | AGO2 AGO1 TNRC6C | Wnt signaling pathway, calcium modulating pathway |
| REAC:R-HSA-1257604 | 0.00498022764952 | 0.6 | AGO2 AGO1 TNRC6C | PIP3 activates AKT signaling |
| REAC:R-HSA-2559585 | 0.00666792835349 | 0.4 | AGO1 TNRC6C | Oncogene Induced Senescence |
| REAC:R-HSA-9006925 | 0.00793834312405 | 0.6 | AGO2 AGO1 TNRC6C | Intracellular signaling by second messengers |
| REAC:R-HSA-3700989 | 0.0182828935298 | 0.6 | AGO2 AGO1 TNRC6C | Transcriptional Regulation by TP53 |
| MIRNA:hsa-miR-6841-3p | 0.0224233322343 | 0.4 | AGO2 TNRC6C | hsa-miR-6841-3p |
| MIRNA:hsa-miR-2277-3p | 0.0334577445892 | 0.4 | TM9SF3 AGO2 | hsa-miR-2277-3p |
| MIRNA:hsa-miR-30d-5p | 0.0350515280025 | 0.6 | AGO2 AGO1 XPO1 | hsa-miR-30d-5p |
| MIRNA:hsa-miR-4509 | 0.0362065585759 | 0.4 | AGO2 TNRC6C | hsa-miR-4509 |
| WP:WP3302 | 0.0497141369515 | 0.2 | XPO1 | eIF5A regulation in response to inhibition of the nuclear export system |
| CORUM:1117 | 0.0499494897235 | 0.2 | XPO1 | CRM1-Survivin mitotic complex |
| CORUM:1387 | 0.0499494897235 | 0.2 | AGO2 | TTP-AGO2 complex |
| CORUM:5360 | 0.0499494897235 | 0.2 | AGO2 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AGO1 | AGO2 | 0.822 | 0.774 | youn (AGO2) bioplex_WMM youn_WMM treiber_WMM |
| AGO2 | TNRC6C | 0.112 | 0.38 | youn (AGO2,TNRC6C) bioplex_WMM youn_WMM |
| XPO1 | TNRC6C | 0.058 | 0.323 | youn (TNRC6C) bioplex_WMM youn_WMM gupta_WMM fraction |
| XPO1 | TM9SF3 | 0.035 | 0.265 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| AGO1 | TNRC6C | 0.024 | 0.213 | youn (TNRC6C) bioplex_WMM youn_WMM fraction |
| AGO2 | XPO1 | 0.007 | 0.01 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| TNRC6C | TM9SF3 | 0.007 | 0.006 | youn (TNRC6C) bioplex_WMM youn_WMM gupta_WMM |
| AGO2 | TM9SF3 | 0.006 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| AGO1 | TM9SF3 | 0.006 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| AGO1 | XPO1 | 0.0 | 0.007 | bioplex_WMM youn_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_00976 has an average edge precision of 0.198 which is ranked 6196 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TM9SF3 | HuMAP2_00976 HuMAP2_01855 |
| AGO1 | HuMAP2_00153 HuMAP2_00288 HuMAP2_00478 HuMAP2_00976 HuMAP2_04674 |
| XPO1 | HuMAP2_00741 HuMAP2_00976 HuMAP2_01855 HuMAP2_03926 HuMAP2_06176 |
| TNRC6C | HuMAP2_00976 HuMAP2_03926 |
| AGO2 | HuMAP2_00288 HuMAP2_00976 HuMAP2_03926 HuMAP2_04674 HuMAP2_06846 |