hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00982
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7267 | 1.00555407742e-05 | 1.0 | OGDH DLST | KAT2A-Oxoglutarate dehydrogenase complex |
| WP:WP2453 | 4.47097598062e-05 | 1.0 | OGDH DLST | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| WP:WP78 | 5.06710611136e-05 | 1.0 | OGDH DLST | TCA Cycle (aka Krebs or citric acid cycle) |
| KEGG:00020 | 5.9234402919e-05 | 1.0 | OGDH DLST | Citrate cycle (TCA cycle) |
| REAC:R-HSA-71064 | 0.000110610948517 | 1.0 | OGDH DLST | Lysine catabolism |
| REAC:R-HSA-71403 | 0.000351943927099 | 1.0 | OGDH DLST | Citric acid cycle (TCA cycle) |
| REAC:R-HSA-389661 | 0.000729026706133 | 1.0 | OGDH DLST | Glyoxylate metabolism and glycine degradation |
| KEGG:01200 | 0.000939726081777 | 1.0 | OGDH DLST | Carbon metabolism |
| WP:WP3925 | 0.00142624133782 | 1.0 | OGDH DLST | Amino Acid metabolism |
| REAC:R-HSA-71406 | 0.00222227451111 | 1.0 | OGDH DLST | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0018335 | 0.00270494046827 | 1.0 | OGDH DLST | protein succinylation |
| GO:0106077 | 0.00270494046827 | 1.0 | OGDH DLST | histone succinylation |
| GO:0006104 | 0.00676235117068 | 1.0 | OGDH DLST | succinyl-CoA metabolic process |
| GO:0045252 | 0.00946729163895 | 1.0 | OGDH DLST | oxoglutarate dehydrogenase complex |
| REAC:R-HSA-1428517 | 0.0226752444459 | 1.0 | OGDH DLST | The citric acid (TCA) cycle and respiratory electron transport |
| HPA:008050_12 | 0.0242338532659 | 1.0 | OGDH DLST | cerebral cortex; neuropil[Supported,Medium] |
| GO:0045240 | 0.0247952876258 | 1.0 | OGDH DLST | dihydrolipoyl dehydrogenase complex |
| HPA:028010_13 | 0.028650749551 | 1.0 | OGDH DLST | lymph node; germinal center cells[Supported,High] |
| GO:0006554 | 0.029754345151 | 1.0 | OGDH DLST | lysine catabolic process |
| GO:0045239 | 0.0351642260875 | 1.0 | OGDH DLST | tricarboxylic acid cycle enzyme complex |
| GO:0006553 | 0.0351642260875 | 1.0 | OGDH DLST | lysine metabolic process |
| WP:WP4236 | 0.038834152205 | 0.5 | DLST | Disorders of the Krebs cycle |
| GO:0006103 | 0.0410249304355 | 1.0 | OGDH DLST | 2-oxoglutarate metabolic process |
| HPA:040010_13 | 0.0474420413729 | 1.0 | OGDH DLST | seminal vesicle; glandular cells[Supported,High] |
| HPA:007010_13 | 0.0480076655415 | 1.0 | OGDH DLST | cerebellum; Purkinje cells[Supported,High] |
| HP:0004902 | 0.0497341708567 | 0.5 | OGDH | Congenital lactic acidosis |
| WP:WP4297 | 0.0499262710315 | 0.5 | OGDH | Thiamine metabolic pathways |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OGDH | DLST | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_00982 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DLST | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |
| OGDH | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |