hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00994
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EXOSC4 | Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A) | UniProt NCBI |
| EXOSC2 | Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:822 | 7.54165558069e-05 | 1.0 | EXOSC4 EXOSC2 | mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) |
| CORUM:788 | 7.54165558069e-05 | 1.0 | EXOSC4 EXOSC2 | Exosome |
| CORUM:789 | 9.21757904306e-05 | 1.0 | EXOSC4 EXOSC2 | Exosome |
| CORUM:7443 | 0.000110610948517 | 1.0 | EXOSC4 EXOSC2 | Exosome |
| REAC:R-HSA-429958 | 0.000201110815485 | 1.0 | EXOSC4 EXOSC2 | mRNA decay by 3' to 5' exoribonuclease |
| REAC:R-HSA-450513 | 0.000227925590883 | 1.0 | EXOSC4 EXOSC2 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
| REAC:R-HSA-450604 | 0.000227925590883 | 1.0 | EXOSC4 EXOSC2 | KSRP (KHSRP) binds and destabilizes mRNA |
| REAC:R-HSA-450385 | 0.000227925590883 | 1.0 | EXOSC4 EXOSC2 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA |
| KEGG:03018 | 0.000415808000786 | 1.0 | EXOSC4 EXOSC2 | RNA degradation |
| REAC:R-HSA-380994 | 0.000462554875615 | 1.0 | EXOSC4 EXOSC2 | ATF4 activates genes in response to endoplasmic reticulum stress |
| REAC:R-HSA-381042 | 0.000680424925724 | 1.0 | EXOSC4 EXOSC2 | PERK regulates gene expression |
| REAC:R-HSA-429914 | 0.00258092213206 | 1.0 | EXOSC4 EXOSC2 | Deadenylation-dependent mRNA decay |
| REAC:R-HSA-381119 | 0.00570316754246 | 1.0 | EXOSC4 EXOSC2 | Unfolded Protein Response (UPR) |
| REAC:R-HSA-450531 | 0.00584226918984 | 1.0 | EXOSC4 EXOSC2 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| WP:WP4352 | 0.0083331540652 | 1.0 | EXOSC4 EXOSC2 | Ciliary landscape |
| GO:0071051 | 0.00946729163895 | 1.0 | EXOSC4 EXOSC2 | polyadenylation-dependent snoRNA 3'-end processing |
| GO:0034475 | 0.0126230555186 | 1.0 | EXOSC4 EXOSC2 | U4 snRNA 3'-end processing |
| GO:0034427 | 0.0162296428096 | 1.0 | EXOSC4 EXOSC2 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' |
| GO:0031126 | 0.0247952876258 | 1.0 | EXOSC4 EXOSC2 | snoRNA 3'-end processing |
| REAC:R-HSA-6791226 | 0.0273007932021 | 1.0 | EXOSC4 EXOSC2 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 0.0304096312248 | 1.0 | EXOSC4 EXOSC2 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.0336860615937 | 1.0 | EXOSC4 EXOSC2 | rRNA processing |
| GO:0071028 | 0.0351642260875 | 1.0 | EXOSC4 EXOSC2 | nuclear mRNA surveillance |
| GO:0071027 | 0.0351642260875 | 1.0 | EXOSC4 EXOSC2 | nuclear RNA surveillance |
| GO:0043144 | 0.0351642260875 | 1.0 | EXOSC4 EXOSC2 | snoRNA processing |
| GO:0071025 | 0.0410249304355 | 1.0 | EXOSC4 EXOSC2 | RNA surveillance |
| GO:0016074 | 0.0410249304355 | 1.0 | EXOSC4 EXOSC2 | snoRNA metabolic process |
| GO:0000177 | 0.0410249304355 | 1.0 | EXOSC4 EXOSC2 | cytoplasmic exosome (RNase complex) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EXOSC4 | EXOSC2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (EXOSC2,EXOSC4) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_00994 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EXOSC4 | HuMAP2_00994 HuMAP2_03073 HuMAP2_05790 |
| EXOSC2 | HuMAP2_00994 HuMAP2_03073 HuMAP2_05790 |