hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00999

Confidence: Medium

Genename	Protein Name	Links
DAZL	Deleted in azoospermia-like (DAZ homolog) (DAZ-like autosomal) (Deleted in azoospermia-like 1) (SPGY-like-autosomal)	UniProt NCBI
ELAVL3	ELAV-like protein 3 (Hu-antigen C) (HuC) (Paraneoplastic cerebellar degeneration-associated antigen) (Paraneoplastic limbic encephalitis antigen 21)	UniProt NCBI
SUGP2	SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14)	UniProt NCBI
TAF15	TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)	UniProt NCBI
IGF2BP2	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)	UniProt NCBI
RO60	60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (Ro60) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2)	UniProt NCBI
PUM2	Pumilio homolog 2 (Pumilio-2)	UniProt NCBI
TOP3B	DNA topoisomerase 3-beta-1 (EC 5.6.2.2) (DNA topoisomerase III beta-1)	UniProt NCBI
ELAVL2	ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Hel-N1)	UniProt NCBI
ELAVL1	ELAV-like protein 1 (Hu-antigen R) (HuR)	UniProt NCBI
HNRNPCL1	Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1)	UniProt NCBI
RBMS2	RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3)	UniProt NCBI
RBM6	RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3)	UniProt NCBI
RBMXL1	RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)	UniProt NCBI
APOBEC3B	DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0003723	2.51377457998e-11	1.0	RBMS2 APOBEC3B IGF2BP2 TAF15 RBM6 PUM2 HNRNPCL1 ELAVL2 DAZL SUGP2 ELAVL1 TOP3B ELAVL3 RBMXL1 RO60	RNA binding
GO:0003676	1.33436727846e-07	1.0	RBMS2 APOBEC3B IGF2BP2 TAF15 RBM6 PUM2 HNRNPCL1 ELAVL2 DAZL SUGP2 ELAVL1 TOP3B ELAVL3 RBMXL1 RO60	nucleic acid binding
GO:0003730	2.95464447633e-06	0.4	IGF2BP2 PUM2 ELAVL2 ELAVL3 ELAVL1 DAZL	mRNA 3'-UTR binding
GO:1901363	3.7253411766e-06	1.0	RBMS2 APOBEC3B IGF2BP2 TAF15 RBM6 PUM2 HNRNPCL1 ELAVL2 DAZL SUGP2 ELAVL1 TOP3B ELAVL3 RBMXL1 RO60	heterocyclic compound binding
GO:0097159	4.83176930268e-06	1.0	RBMS2 APOBEC3B IGF2BP2 TAF15 RBM6 PUM2 HNRNPCL1 ELAVL2 DAZL SUGP2 ELAVL1 TOP3B ELAVL3 RBMXL1 RO60	organic cyclic compound binding
GO:0003729	0.00200212155883	0.4	IGF2BP2 PUM2 ELAVL2 ELAVL3 ELAVL1 DAZL	mRNA binding
GO:1903311	0.0102935545465	0.4	PUM2 TAF15 RBMXL1 IGF2BP2 ELAVL1 DAZL	regulation of mRNA metabolic process
GO:0043488	0.0179311221039	0.333333333333	ELAVL1 IGF2BP2 DAZL PUM2 TAF15	regulation of mRNA stability
GO:0043487	0.0202891594379	0.333333333333	ELAVL1 IGF2BP2 DAZL PUM2 TAF15	regulation of RNA stability
GO:0061013	0.0314079463625	0.333333333333	ELAVL1 IGF2BP2 DAZL PUM2 TAF15	regulation of mRNA catabolic process

Edges

Protein 1	Protein 2	Score	Precision	Evidence
ELAVL2	ELAVL3	0.988	0.901	bioplex (ELAVL2) bioplex_WMM
ELAVL2	ELAVL1	0.797	0.763	hein_WMM youn (ELAVL1) bioplex (ELAVL2) bioplex_WMM youn_WMM hein (ELAVL1)
IGF2BP2	ELAVL2	0.161	0.417	youn (IGF2BP2) bioplex (ELAVL2) bioplex_WMM youn_WMM treiber_WMM
APOBEC3B	ELAVL2	0.159	0.416	bioplex (ELAVL2) bioplex_WMM
ELAVL2	RBMXL1	0.068	0.348	bioplex (ELAVL2) bioplex_WMM
TAF15	RBM6	0.048	0.294	hein_WMM bioplex (RBM6) youn_WMM hein (TAF15) treiber_WMM
HNRNPCL1	ELAVL2	0.046	0.293	bioplex (ELAVL2) bioplex_WMM
TAF15	RBMXL1	0.042	0.269	hein_WMM bioplex_WMM hein (TAF15) treiber_WMM
ELAVL2	PUM2	0.039	0.264	bioplex (ELAVL2) bioplex_WMM youn_WMM
IGF2BP2	TOP3B	0.035	0.26	youn (IGF2BP2,TOP3B) youn_WMM gupta_WMM
RBM6	ELAVL1	0.035	0.263	hein_WMM youn (ELAVL1) bioplex (RBM6) bioplex_WMM youn_WMM gupta_WMM
RBMS2	ELAVL2	0.028	0.23	bioplex (ELAVL2) bioplex_WMM youn_WMM treiber_WMM
ELAVL2	RO60	0.028	0.231	bioplex (ELAVL2) bioplex_WMM youn_WMM
DAZL	TOP3B	0.025	0.21	youn (DAZL)
ELAVL2	SUGP2	0.022	0.21	bioplex (ELAVL2) bioplex_WMM youn_WMM
RBMS2	PUM2	0.01	0.134	bioplex_WMM youn_WMM WMM_only
APOBEC3B	RBMXL1	0.01	0.119	hein_WMM bioplex_WMM WMM_only treiber_WMM
DAZL	PUM2	0.01	0.1	youn (DAZL)
IGF2BP2	RBMXL1	0.009	0.096	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
APOBEC3B	ELAVL3	0.008	0.091	bioplex_WMM WMM_only
RBMS2	ELAVL3	0.008	0.091	bioplex_WMM WMM_only
RBMXL1	PUM2	0.008	0.086	bioplex_WMM youn_WMM WMM_only
RBMS2	APOBEC3B	0.008	0.083	bioplex_WMM WMM_only treiber_WMM
HNRNPCL1	ELAVL3	0.008	0.068	bioplex_WMM WMM_only
RBMXL1	ELAVL1	0.008	0.066	bioplex_WMM youn_WMM gupta_WMM WMM_only
SUGP2	PUM2	0.008	0.062	bioplex_WMM youn_WMM WMM_only treiber_WMM
ELAVL3	PUM2	0.008	0.06	bioplex_WMM WMM_only
ELAVL3	RBMXL1	0.008	0.06	bioplex_WMM WMM_only
APOBEC3B	HNRNPCL1	0.008	0.045	bioplex_WMM WMM_only
RBMS2	HNRNPCL1	0.008	0.045	bioplex_WMM WMM_only
APOBEC3B	PUM2	0.008	0.029	bioplex_WMM WMM_only treiber_WMM
RBMS2	RBMXL1	0.008	0.023	bioplex_WMM youn_WMM WMM_only treiber_WMM
RBM6	RBMXL1	0.008	0.024	hein_WMM bioplex_WMM WMM_only
ELAVL3	ELAVL1	0.008	0.013	bioplex_WMM WMM_only
RBMS2	TOP3B	0.008	0.01	youn_WMM WMM_only
RBMS2	SUGP2	0.007	0.012	bioplex_WMM youn_WMM WMM_only treiber_WMM
RBM6	SUGP2	0.007	0.008	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
ELAVL3	SUGP2	0.007	0.009	bioplex_WMM WMM_only
RBMXL1	SUGP2	0.007	0.009	bioplex_WMM youn_WMM gupta_WMM WMM_only
DAZL	SUGP2	0.007	0.008	youn (DAZL)
TOP3B	SUGP2	0.007	0.008	youn (TOP3B) youn_WMM gupta_WMM treiber_WMM
HNRNPCL1	ELAVL1	0.007	0.005	bioplex_WMM youn_WMM WMM_only
DAZL	ELAVL1	0.007	0.002	youn (DAZL)
APOBEC3B	ELAVL1	0.007	0.004	hein_WMM bioplex_WMM WMM_only treiber_WMM
IGF2BP2	ELAVL3	0.007	0.003	bioplex_WMM WMM_only
RBMS2	TAF15	0.007	0.007	youn_WMM WMM_only treiber_WMM
HNRNPCL1	PUM2	0.007	0.007	bioplex_WMM WMM_only
TAF15	PUM2	0.007	0.01	youn_WMM WMM_only treiber_WMM
TAF15	TOP3B	0.007	0.01	youn_WMM WMM_only treiber_WMM
TOP3B	PUM2	0.007	0.007	youn_WMM WMM_only treiber_WMM
ELAVL3	RO60	0.007	0.008	bioplex_WMM WMM_only
TAF15	RO60	0.007	0.004	bioplex_WMM youn_WMM WMM_only treiber_WMM
TAF15	APOBEC3B	0.007	0.009	hein_WMM bioplex (APOBEC3B) hein (TAF15) treiber_WMM
IGF2BP2	APOBEC3B	0.007	0.004	bioplex_WMM WMM_only treiber_WMM
RBMS2	RO60	0.007	0.007	bioplex_WMM youn_WMM WMM_only
RBMS2	RBM6	0.007	0.004	youn_WMM WMM_only
APOBEC3B	SUGP2	0.007	0.006	hein_WMM bioplex_WMM WMM_only
APOBEC3B	RO60	0.007	0.002	bioplex_WMM WMM_only
ELAVL2	TOP3B	0.007	0.004	youn_WMM WMM_only
RBM6	TOP3B	0.007	0.006	youn_WMM WMM_only treiber_WMM
RBM6	RO60	0.007	0.004	youn_WMM WMM_only
RBMXL1	TOP3B	0.007	0.001	youn_WMM gupta_WMM WMM_only
RBM6	PUM2	0.007	0.006	youn_WMM WMM_only treiber_WMM
TOP3B	RO60	0.007	0.001	youn_WMM gupta_WMM WMM_only
HNRNPCL1	TOP3B	0.007	0.002	youn_WMM WMM_only
RBM6	ELAVL2	0.007	0.003	bioplex_WMM youn_WMM WMM_only
HNRNPCL1	SUGP2	0.007	0.006	bioplex_WMM WMM_only
RBM6	APOBEC3B	0.007	0.002	hein_WMM WMM_only
RBM6	IGF2BP2	0.007	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
TAF15	ELAVL2	0.007	0.004	bioplex (ELAVL2) bioplex_WMM youn_WMM
TAF15	SUGP2	0.007	0.003	hein_WMM bioplex (SUGP2) bioplex_WMM youn_WMM treiber_WMM
HNRNPCL1	RO60	0.007	0.008	bioplex_WMM WMM_only
RO60	PUM2	0.007	0.004	bioplex_WMM youn_WMM WMM_only
ELAVL1	RO60	0.007	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RBMXL1	RO60	0.006	0.004	bioplex_WMM WMM_only
ELAVL1	SUGP2	0.006	0.004	hein_WMM youn (ELAVL1) bioplex (SUGP2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
RBMS2	DAZL	0.006	0.005	youn (DAZL)
TAF15	IGF2BP2	0.006	0.006	youn (IGF2BP2) bioplex_WMM youn_WMM treiber_WMM
SUGP2	RO60	0.006	0.007	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RBMS2	IGF2BP2	0.006	0.007	youn (IGF2BP2) bioplex_WMM youn_WMM treiber_WMM
TAF15	ELAVL1	0.006	0.003	hein_WMM youn (ELAVL1) bioplex_WMM youn_WMM treiber_WMM
RBMS2	ELAVL1	0.006	0.008	youn (ELAVL1) bioplex_WMM youn_WMM treiber_WMM
IGF2BP2	PUM2	0.005	0.011	youn (IGF2BP2) bioplex_WMM youn_WMM treiber_WMM
ELAVL1	PUM2	0.005	0.011	youn (ELAVL1) bioplex_WMM youn_WMM treiber_WMM
RBM6	DAZL	0.005	0.006	youn (DAZL)
TOP3B	ELAVL1	0.005	0.01	youn (ELAVL1,TOP3B) youn_WMM gupta_WMM
DAZL	ELAVL2	0.005	0.009	youn (DAZL)
IGF2BP2	DAZL	0.005	0.009	youn (DAZL)
TAF15	DAZL	0.005	0.008	youn (DAZL)
IGF2BP2	RO60	0.004	0.012	youn (IGF2BP2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
IGF2BP2	SUGP2	0.004	0.009	youn (IGF2BP2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
IGF2BP2	ELAVL1	0.003	0.011	youn (ELAVL1,IGF2BP2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
IGF2BP2	HNRNPCL1	0.0	0.013	bioplex_WMM youn_WMM fraction
HNRNPCL1	RBMXL1	0.0	0.006	bioplex_WMM youn_WMM fraction

Images

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Complex HuMAP2_00999 has an average edge precision of 0.075 which is ranked 6967 out of all 6965 complexes.

Related Complexes

Genename	Complexes
DAZL	HuMAP2_00902 HuMAP2_00999 HuMAP2_03185 HuMAP2_06246
ELAVL3	HuMAP2_00913 HuMAP2_00999 HuMAP2_02016 HuMAP2_05399 HuMAP2_06202 HuMAP2_06650
SUGP2	HuMAP2_00999 HuMAP2_02016 HuMAP2_03605 HuMAP2_05013 HuMAP2_05222 HuMAP2_06650
TAF15	HuMAP2_00529 HuMAP2_00999 HuMAP2_02857 HuMAP2_03994
IGF2BP2	HuMAP2_00556 HuMAP2_00999 HuMAP2_04632 HuMAP2_06202 HuMAP2_06751
RO60	HuMAP2_00999 HuMAP2_02016 HuMAP2_06650
PUM2	HuMAP2_00999 HuMAP2_02016 HuMAP2_06650
TOP3B	HuMAP2_00999 HuMAP2_01454 HuMAP2_04768 HuMAP2_06246
ELAVL2	HuMAP2_00913 HuMAP2_00999 HuMAP2_02016 HuMAP2_05399 HuMAP2_06202 HuMAP2_06650
ELAVL1	HuMAP2_00999 HuMAP2_02857 HuMAP2_03232 HuMAP2_05399
HNRNPCL1	HuMAP2_00913 HuMAP2_00999 HuMAP2_02016 HuMAP2_06202 HuMAP2_06650
RBMS2	HuMAP2_00002 HuMAP2_00999 HuMAP2_02016 HuMAP2_04289 HuMAP2_06099 HuMAP2_06650
RBM6	HuMAP2_00529 HuMAP2_00999 HuMAP2_02857 HuMAP2_03994
RBMXL1	HuMAP2_00999 HuMAP2_03337 HuMAP2_05525
APOBEC3B	HuMAP2_00913 HuMAP2_00999 HuMAP2_02016 HuMAP2_06202 HuMAP2_06650

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00999