hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01003
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDK1 | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | UniProt NCBI |
| CKS1B | Cyclin-dependent kinases regulatory subunit 1 (CKS-1) | UniProt NCBI |
| CCNA2 | Cyclin-A2 (Cyclin-A) (Cyclin A) | UniProt NCBI |
| CCNB1 | G2/mitotic-specific cyclin-B1 | UniProt NCBI |
| CCNE1 | G1/S-specific cyclin-E1 | UniProt NCBI |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | UniProt NCBI |
| PKMYT1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | UniProt NCBI |
| RBL2 | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | UniProt NCBI |
| SKP2 | S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) | UniProt NCBI |
| CDK2 | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | UniProt NCBI |
| CCNB2 | G2/mitotic-specific cyclin-B2 | UniProt NCBI |
| CKS2 | Cyclin-dependent kinases regulatory subunit 2 (CKS-2) | UniProt NCBI |
| GMNN | Geminin | UniProt NCBI |
| RBL1 | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | UniProt NCBI |
| CDT1 | DNA replication factor Cdt1 (Double parked homolog) (DUP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-69206 | 1.39223827702e-20 | 0.8 | RBL2 CCNE1 SKP2 CKS1B GMNN CDKN1B CDK2 CDK1 CCNA2 RBL1 CCNB1 CDT1 | G1/S Transition |
| REAC:R-HSA-453279 | 6.45397065272e-20 | 0.8 | RBL2 CCNE1 SKP2 CKS1B GMNN CDKN1B CDK2 CDK1 CCNA2 RBL1 CCNB1 CDT1 | Mitotic G1-G1/S phases |
| WP:WP179 | 3.62063762189e-19 | 0.733333333333 | RBL2 SKP2 RBL1 CCNE1 CDKN1B CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | Cell Cycle |
| KEGG:04110 | 4.12546481647e-19 | 0.733333333333 | RBL2 SKP2 RBL1 CCNE1 CDKN1B CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | Cell cycle |
| REAC:R-HSA-69278 | 1.18025886722e-17 | 0.933333333333 | RBL2 SKP2 RBL1 CKS1B CCNE1 GMNN CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CDKN1B CCNB2 CDT1 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 1.50899878198e-16 | 0.933333333333 | RBL2 SKP2 RBL1 CKS1B CCNE1 GMNN CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CDKN1B CCNB2 CDT1 | Cell Cycle |
| WP:WP2446 | 1.74050327005e-15 | 0.6 | SKP2 CCNE1 CDKN1B CDK2 CDK1 CCNA2 CCNB1 CCNB2 CDT1 | Retinoblastoma Gene in Cancer |
| GO:0000278 | 7.13809539628e-15 | 1.0 | RBL2 SKP2 RBL1 CKS2 CCNE1 CCNA2 CDK2 CDK1 PKMYT1 CCNB1 CDKN1B CCNB2 GMNN CDT1 CKS1B | mitotic cell cycle |
| REAC:R-HSA-6791312 | 1.07083983004e-14 | 0.533333333333 | RBL2 CCNE1 CDKN1B CCNA2 CDK2 CDK1 RBL1 CCNB1 | TP53 Regulates Transcription of Cell Cycle Genes |
| GO:0051726 | 2.34184469391e-14 | 1.0 | RBL2 SKP2 RBL1 CKS2 CCNE1 CCNA2 CDK2 CDK1 PKMYT1 CCNB1 CDKN1B CCNB2 GMNN CDT1 CKS1B | regulation of cell cycle |
| GO:0000307 | 1.24907440686e-13 | 0.533333333333 | CKS2 CCNE1 CCNA2 CDK2 CDK1 CCNB1 CCNB2 CKS1B | cyclin-dependent protein kinase holoenzyme complex |
| GO:0044772 | 1.26061621232e-13 | 0.866666666667 | RBL2 SKP2 RBL1 CCNE1 GMNN CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CDKN1B CCNB2 CDT1 | mitotic cell cycle phase transition |
| GO:0044843 | 2.56435773556e-13 | 0.733333333333 | RBL2 CCNE1 SKP2 GMNN CDKN1B CDK2 CDK1 CCNA2 RBL1 CCNB1 CDT1 | cell cycle G1/S phase transition |
| GO:0044770 | 2.91589479795e-13 | 0.866666666667 | RBL2 SKP2 RBL1 CCNE1 GMNN CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CDKN1B CCNB2 CDT1 | cell cycle phase transition |
| CORUM:3015 | 1.36169126961e-12 | 0.333333333333 | CKS1B SKP2 CDK2 CCNE1 CDKN1B | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex |
| GO:0007049 | 6.03676066905e-12 | 1.0 | RBL2 SKP2 RBL1 CKS2 CCNE1 CCNA2 CDK2 CDK1 PKMYT1 CCNB1 CDKN1B CCNB2 GMNN CDT1 CKS1B | cell cycle |
| REAC:R-HSA-69273 | 1.55776873863e-11 | 0.4 | CCNA2 PKMYT1 CDK2 CDK1 CCNB1 CCNB2 | Cyclin A/B1/B2 associated events during G2/M transition |
| KEGG:04218 | 2.15573590278e-11 | 0.533333333333 | RBL2 RBL1 CCNE1 CCNA2 CDK2 CDK1 CCNB1 CCNB2 | Cellular senescence |
| GO:0000082 | 2.26676452337e-11 | 0.666666666667 | RBL2 CCNE1 SKP2 CDKN1B GMNN CDK2 CDK1 RBL1 CCNB1 CDT1 | G1/S transition of mitotic cell cycle |
| REAC:R-HSA-1538133 | 2.6009991151e-11 | 0.4 | RBL2 CCNA2 CCNE1 CDK2 CDK1 RBL1 | G0 and Early G1 |
| GO:1903047 | 3.05346995483e-11 | 0.866666666667 | RBL2 SKP2 RBL1 CCNE1 GMNN CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CDKN1B CCNB2 CDT1 | mitotic cell cycle process |
| GO:1902554 | 7.86892636748e-11 | 0.533333333333 | CKS2 CCNE1 CCNA2 CDK2 CDK1 CCNB1 CCNB2 CKS1B | serine/threonine protein kinase complex |
| GO:0016538 | 1.01390198825e-10 | 0.466666666667 | CKS2 CDKN1B CCNE1 CCNA2 CCNB1 CCNB2 CKS1B | cyclin-dependent protein serine/threonine kinase regulator activity |
| KEGG:05203 | 1.7694019221e-10 | 0.533333333333 | RBL2 CCNE1 SKP2 CDKN1B CCNA2 CDK2 CDK1 RBL1 | Viral carcinogenesis |
| REAC:R-HSA-69202 | 1.97062732105e-10 | 0.466666666667 | RBL2 CCNE1 SKP2 CKS1B CDKN1B CCNA2 CDK2 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69242 | 2.29438442529e-10 | 0.533333333333 | RBL2 CCNE1 SKP2 CKS1B CDKN1B CCNA2 CDK2 CDT1 | S Phase |
| REAC:R-HSA-69656 | 2.34556476888e-10 | 0.466666666667 | RBL2 CCNE1 SKP2 CKS1B CDKN1B CCNA2 CDK2 | Cyclin A:Cdk2-associated events at S phase entry |
| GO:1902911 | 3.33628063025e-10 | 0.533333333333 | CKS2 CCNE1 CCNA2 CDK2 CDK1 CCNB1 CCNB2 CKS1B | protein kinase complex |
| REAC:R-HSA-69478 | 8.94630670909e-10 | 0.266666666667 | CCNB2 CDK1 PKMYT1 CCNB1 | G2/M DNA replication checkpoint |
| WP:WP707 | 2.20952623538e-09 | 0.4 | CDKN1B CCNE1 CDK2 CDK1 CCNB1 CCNB2 | DNA Damage Response |
| WP:WP1530 | 2.89844931937e-09 | 0.4 | CDKN1B CCNE1 CDK2 CDK1 CCNB1 CCNB2 | miRNA Regulation of DNA Damage Response |
| REAC:R-HSA-187577 | 3.89390322908e-09 | 0.4 | CCNE1 SKP2 CKS1B CDKN1B CCNA2 CDK2 | SCF(Skp2)-mediated degradation of p27/p21 |
| GO:0007346 | 4.67997111126e-09 | 0.733333333333 | RBL2 RBL1 CKS2 CDKN1B CCNE1 CDK2 CDK1 PKMYT1 CKS1B CCNB1 CDT1 | regulation of mitotic cell cycle |
| KEGG:04914 | 5.51006644272e-09 | 0.4 | CCNA2 PKMYT1 CDK2 CDK1 CCNB1 CCNB2 | Progesterone-mediated oocyte maturation |
| GO:0022402 | 7.83263446832e-09 | 0.866666666667 | RBL2 SKP2 RBL1 CCNE1 GMNN CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CDKN1B CCNB2 CDT1 | cell cycle process |
| KEGG:05222 | 1.20374352563e-08 | 0.4 | SKP2 CKS2 CCNE1 CDKN1B CDK2 CKS1B | Small cell lung cancer |
| REAC:R-HSA-69205 | 1.2832132813e-08 | 0.333333333333 | RBL2 CDT1 CCNE1 RBL1 CDK1 | G1/S-Specific Transcription |
| WP:WP53 | 2.26911334541e-08 | 0.266666666667 | RBL2 CDK2 CCNE1 RBL1 | ID signaling pathway |
| REAC:R-HSA-69620 | 2.6545572172e-08 | 0.533333333333 | CCNE1 CDKN1B CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | Cell Cycle Checkpoints |
| KEGG:04114 | 3.02711226291e-08 | 0.4 | CCNE1 PKMYT1 CDK2 CDK1 CCNB1 CCNB2 | Oocyte meiosis |
| CORUM:1656 | 4.09133189015e-08 | 0.2 | CDK2 CCNE1 CDKN1B | p27-cyclinE-CDK2 complex |
| CORUM:5559 | 4.09133189015e-08 | 0.2 | CDK2 CCNA2 CDK1 | CDC2-CCNA2-CDK2 complex |
| KEGG:04068 | 4.45080753321e-08 | 0.4 | RBL2 SKP2 CDKN1B CDK2 CCNB1 CCNB2 | FoxO signaling pathway |
| REAC:R-HSA-69231 | 1.10201025965e-07 | 0.333333333333 | RBL2 SKP2 CDKN1B RBL1 CKS1B | Cyclin D associated events in G1 |
| REAC:R-HSA-69236 | 1.10201025965e-07 | 0.333333333333 | RBL2 SKP2 CDKN1B RBL1 CKS1B | G1 Phase |
| REAC:R-HSA-3700989 | 1.22984501032e-07 | 0.533333333333 | RBL2 CCNE1 CDKN1B CCNA2 CDK2 CDK1 RBL1 CCNB1 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-6804116 | 1.78154499964e-07 | 0.266666666667 | CDKN1B CDK2 CCNA2 CCNE1 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| KEGG:04115 | 1.93871964737e-07 | 0.333333333333 | CDK1 CCNB2 CDK2 CCNE1 CCNB1 | p53 signaling pathway |
| WP:WP45 | 2.31509239612e-07 | 0.333333333333 | CDKN1B CCNB1 CDK2 CCNE1 CDK1 | G1 to S cell cycle control |
| REAC:R-HSA-1362300 | 3.23534389377e-07 | 0.266666666667 | RBL2 CCNA2 RBL1 CDK1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| REAC:R-HSA-69306 | 4.11050291461e-07 | 0.4 | CCNE1 SKP2 GMNN CCNA2 CDK2 CDT1 | DNA Replication |
| GO:2000045 | 5.3071596123e-07 | 0.466666666667 | RBL2 CDKN1B CCNE1 CDK2 CDK1 RBL1 CCNB1 | regulation of G1/S transition of mitotic cell cycle |
| REAC:R-HSA-6804114 | 5.43321384826e-07 | 0.266666666667 | CCNB1 CDK1 RBL1 RBL2 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| GO:0061695 | 6.55030430516e-07 | 0.533333333333 | CKS2 CCNE1 CCNA2 CDK2 CDK1 CCNB1 CCNB2 CKS1B | transferase complex, transferring phosphorus-containing groups |
| CORUM:310 | 8.16783593962e-07 | 0.2 | CCNB2 CDK1 CCNB1 | Cell cycle kinase complex CDC2 |
| GO:1902806 | 9.95626760843e-07 | 0.466666666667 | RBL2 CDKN1B CCNE1 CDK2 CDK1 RBL1 CCNB1 | regulation of cell cycle G1/S phase transition |
| GO:0019887 | 1.3716131488e-06 | 0.466666666667 | CKS2 CDKN1B CCNE1 CCNA2 CCNB1 CCNB2 CKS1B | protein kinase regulator activity |
| WP:WP4658 | 1.87440015891e-06 | 0.333333333333 | CKS2 CDK2 CKS1B CCNE1 CDKN1B | Small cell lung cancer |
| REAC:R-HSA-8849470 | 2.2189525236e-06 | 0.2 | CDK2 CCNE1 CDKN1B | PTK6 Regulates Cell Cycle |
| GO:0000079 | 2.28782719415e-06 | 0.4 | CDKN1B CCNE1 PKMYT1 CCNA2 CCNB1 CCNB2 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:1904029 | 2.95464447633e-06 | 0.4 | CDKN1B CCNE1 PKMYT1 CCNA2 CCNB1 CCNB2 | regulation of cyclin-dependent protein kinase activity |
| WP:WP2516 | 3.71069731206e-06 | 0.266666666667 | CCNB1 CDK2 CCNE1 CDK1 | ATM Signaling Pathway |
| GO:0019207 | 3.96420516104e-06 | 0.466666666667 | CKS2 CDKN1B CCNE1 CCNA2 CCNB1 CCNB2 CKS1B | kinase regulator activity |
| REAC:R-HSA-174143 | 4.14800405231e-06 | 0.333333333333 | CCNB1 SKP2 CDK2 CCNA2 CDK1 | APC/C-mediated degradation of cell cycle proteins |
| REAC:R-HSA-453276 | 4.14800405231e-06 | 0.333333333333 | CCNB1 SKP2 CDK2 CCNA2 CDK1 | Regulation of mitotic cell cycle |
| REAC:R-HSA-69275 | 4.87002317596e-06 | 0.4 | CCNA2 PKMYT1 CDK2 CDK1 CCNB1 CCNB2 | G2/M Transition |
| REAC:R-HSA-453274 | 5.1847374182e-06 | 0.4 | CCNA2 PKMYT1 CDK2 CDK1 CCNB1 CCNB2 | Mitotic G2-G2/M phases |
| REAC:R-HSA-69052 | 5.23717930413e-06 | 0.333333333333 | CDK2 SKP2 CDT1 CCNA2 CCNE1 | Switching of origins to a post-replicative state |
| GO:1990234 | 5.90347316799e-06 | 0.666666666667 | SKP2 CKS2 CCNE1 CCNA2 CDK2 CDK1 CCNB1 CDKN1B CCNB2 CKS1B | transferase complex |
| KEGG:05200 | 7.64822286731e-06 | 0.466666666667 | CCNE1 SKP2 CKS2 CDKN1B CCNA2 CDK2 CKS1B | Pathways in cancer |
| REAC:R-HSA-2980767 | 7.7569485367e-06 | 0.2 | CCNB2 CDK1 CCNB1 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| GO:2000134 | 7.99988888764e-06 | 0.4 | RBL2 CDKN1B CDK2 CDK1 RBL1 CCNB1 | negative regulation of G1/S transition of mitotic cell cycle |
| GO:1902807 | 8.58078080378e-06 | 0.4 | RBL2 CDKN1B CDK2 CDK1 RBL1 CCNB1 | negative regulation of cell cycle G1/S phase transition |
| CORUM:1005 | 1.16306758462e-05 | 0.2 | CCNB1 CCNA2 CDK1 | RC complex during G2/M-phase of cell cycle |
| WP:000000 | 1.34980501208e-05 | 1.0 | RBL2 SKP2 RBL1 CKS2 CCNE1 CCNA2 CDK2 CDK1 PKMYT1 CCNB1 CDKN1B CCNB2 GMNN CDT1 CKS1B | WIKIPATHWAYS |
| CORUM:0000000 | 1.56863806762e-05 | 0.866666666667 | RBL2 SKP2 RBL1 CKS1B CCNE1 GMNN CDK2 CDK1 CCNA2 CCNB1 CDKN1B CCNB2 CDT1 | CORUM root |
| KEGG:05165 | 1.83657031039e-05 | 0.4 | RBL2 CCNE1 CDKN1B CCNA2 CDK2 RBL1 | Human papillomavirus infection |
| GO:1901991 | 1.94055580051e-05 | 0.466666666667 | RBL2 CDKN1B CDK2 CDK1 RBL1 CCNB1 CDT1 | negative regulation of mitotic cell cycle phase transition |
| REAC:R-HSA-69239 | 2.17188510759e-05 | 0.333333333333 | CDK2 SKP2 CDT1 CCNA2 CCNE1 | Synthesis of DNA |
| GO:1901990 | 2.2875117192e-05 | 0.533333333333 | RBL2 CDKN1B CCNE1 CDK2 CDK1 RBL1 CCNB1 CDT1 | regulation of mitotic cell cycle phase transition |
| WP:WP2032 | 3.00776163747e-05 | 0.266666666667 | RBL2 CDK2 CCNE1 CDKN1B | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| GO:1901988 | 3.03014682615e-05 | 0.466666666667 | RBL2 CDKN1B CDK2 CDK1 RBL1 CCNB1 CDT1 | negative regulation of cell cycle phase transition |
| GO:0090068 | 3.13212596878e-05 | 0.466666666667 | RBL2 CDKN1B CCNE1 CDK2 CDK1 CCNB1 CDT1 | positive regulation of cell cycle process |
| REAC:R-HSA-212436 | 3.32569753434e-05 | 0.6 | RBL2 CCNE1 SKP2 CDKN1B CCNA2 CDK2 CDK1 RBL1 CCNB1 | Generic Transcription Pathway |
| REAC:R-HSA-2514853 | 3.64801385431e-05 | 0.2 | CCNB2 CDK1 CCNB1 | Condensation of Prometaphase Chromosomes |
| GO:0043549 | 3.81357926358e-05 | 0.6 | RBL2 RBL1 CCNE1 CDKN1B PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | regulation of kinase activity |
| KEGG:05169 | 3.84921786642e-05 | 0.333333333333 | CDKN1B CDK2 SKP2 CCNA2 CCNE1 | Epstein-Barr virus infection |
| GO:1901987 | 3.96411361184e-05 | 0.533333333333 | RBL2 CDKN1B CCNE1 CDK2 CDK1 RBL1 CCNB1 CDT1 | regulation of cell cycle phase transition |
| GO:0000086 | 4.60359984183e-05 | 0.466666666667 | SKP2 CCNA2 PKMYT1 CDK2 CDK1 CCNB1 CCNB2 | G2/M transition of mitotic cell cycle |
| CORUM:5557 | 4.68677803909e-05 | 0.133333333333 | CCNA2 CDK1 | CDC2-CCNA2 complex |
| CORUM:5556 | 4.68677803909e-05 | 0.133333333333 | CDK2 CCNA2 | CDK2-CCNA2 complex |
| CORUM:5550 | 4.68677803909e-05 | 0.133333333333 | CCNB1 CDK1 | CDK1-CCNB1-CCNF complex |
| CORUM:5543 | 4.68677803909e-05 | 0.133333333333 | CCNB1 CDK1 | CCNB1-CDC2 complex |
| CORUM:6140 | 4.68677803909e-05 | 0.133333333333 | GMNN CDT1 | Cdt1-Geminin complex |
| CORUM:5542 | 4.68677803909e-05 | 0.133333333333 | CCNB2 CDK1 | CCNB2-CDC2 complex |
| CORUM:5560 | 4.68677803909e-05 | 0.133333333333 | CDK2 CCNE1 | CDK2-CCNE1 complex |
| GO:0010564 | 5.70949957703e-05 | 0.6 | RBL2 CDKN1B CCNE1 CDK2 CDK1 PKMYT1 RBL1 CCNB1 CDT1 | regulation of cell cycle process |
| REAC:R-HSA-162658 | 6.3155820455e-05 | 0.2 | CCNB2 CDK1 CCNB1 | Golgi Cisternae Pericentriolar Stack Reorganization |
| GO:0006977 | 7.56915745029e-05 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| GO:0044839 | 7.89650037254e-05 | 0.466666666667 | SKP2 CCNA2 PKMYT1 CDK2 CDK1 CCNB1 CCNB2 | cell cycle G2/M phase transition |
| GO:1902400 | 8.32140362253e-05 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | intracellular signal transduction involved in G1 DNA damage checkpoint |
| GO:0072431 | 8.32140362253e-05 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | signal transduction involved in mitotic G1 DNA damage checkpoint |
| REAC:R-HSA-73857 | 8.49650248443e-05 | 0.6 | RBL2 CCNE1 SKP2 CDKN1B CCNA2 CDK2 CDK1 RBL1 CCNB1 | RNA Polymerase II Transcription |
| GO:0072413 | 9.13210279608e-05 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | signal transduction involved in mitotic cell cycle checkpoint |
| GO:1902403 | 9.13210279608e-05 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | signal transduction involved in mitotic DNA integrity checkpoint |
| GO:1902402 | 9.13210279608e-05 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | signal transduction involved in mitotic DNA damage checkpoint |
| REAC:R-HSA-69481 | 0.000123045701948 | 0.333333333333 | CCNB2 CDK2 CDK1 PKMYT1 CCNB1 | G2/M Checkpoints |
| REAC:R-HSA-156711 | 0.000123437628475 | 0.2 | CCNB2 PKMYT1 CCNB1 | Polo-like kinase mediated events |
| REAC:R-HSA-69580 | 0.000124383788889 | 0.266666666667 | CDKN1B CDK2 CCNA2 CCNE1 | p53-Dependent G1/S DNA damage checkpoint |
| REAC:R-HSA-69563 | 0.000124383788889 | 0.266666666667 | CDKN1B CDK2 CCNA2 CCNE1 | p53-Dependent G1 DNA Damage Response |
| GO:0031571 | 0.000130276640623 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | mitotic G1 DNA damage checkpoint |
| GO:0044819 | 0.000130276640623 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | mitotic G1/S transition checkpoint |
| GO:0051338 | 0.000134965376984 | 0.6 | RBL2 RBL1 CCNE1 CDKN1B PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | regulation of transferase activity |
| REAC:R-HSA-69615 | 0.000140382342063 | 0.266666666667 | CDKN1B CDK2 CCNA2 CCNE1 | G1/S DNA Damage Checkpoints |
| CORUM:5159 | 0.000140521514535 | 0.133333333333 | RBL1 CCNE1 | E2F4-p107-cyclinE complex |
| CORUM:5144 | 0.000140521514535 | 0.133333333333 | RBL1 CCNA2 | E2F1-p107-cyclinA complex |
| CORUM:6954 | 0.000140521514535 | 0.133333333333 | GMNN CDT1 | Idas-Geminin-Cdt1 complex |
| CORUM:1661 | 0.000140521514535 | 0.133333333333 | RBL1 CCNA2 | E2F4-p107-cyclinA complex |
| CORUM:5551 | 0.000140521514535 | 0.133333333333 | CCNB1 CDK1 | CDC2-CCNB1-PTCH1 complex |
| CORUM:243 | 0.000140521514535 | 0.133333333333 | CCNB1 CDK1 | RalBP1-CDC2-CCNB1 complex |
| GO:0044783 | 0.000141828876147 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | G1 DNA damage checkpoint |
| GO:0031570 | 0.000144577284398 | 0.4 | RBL2 CDKN1B CDK2 CDK1 CCNB1 CDT1 | DNA integrity checkpoint |
| GO:0045787 | 0.000156575229486 | 0.466666666667 | RBL2 CDKN1B CCNE1 CDK2 CDK1 CCNB1 CDT1 | positive regulation of cell cycle |
| GO:0045930 | 0.000160697929935 | 0.466666666667 | RBL2 CDKN1B CDK2 CDK1 RBL1 CCNB1 CDT1 | negative regulation of mitotic cell cycle |
| REAC:R-HSA-68949 | 0.000167191453421 | 0.266666666667 | CDK2 CDT1 CCNA2 SKP2 | Orc1 removal from chromatin |
| GO:0007093 | 0.000202148577876 | 0.4 | RBL2 CDKN1B CDK2 CDK1 CCNB1 CDT1 | mitotic cell cycle checkpoint |
| REAC:R-HSA-74160 | 0.000216192408235 | 0.6 | RBL2 CCNE1 SKP2 CDKN1B CCNA2 CDK2 CDK1 RBL1 CCNB1 | Gene expression (Transcription) |
| GO:0010948 | 0.000252392189494 | 0.466666666667 | RBL2 CDKN1B CDK2 CDK1 RBL1 CCNB1 CDT1 | negative regulation of cell cycle process |
| REAC:R-HSA-2559586 | 0.000257316254549 | 0.266666666667 | CDKN1B CDK2 CCNA2 CCNE1 | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-176408 | 0.000257316254549 | 0.266666666667 | CCNB1 CDK2 CCNA2 CDK1 | Regulation of APC/C activators between G1/S and early anaphase |
| GO:0072422 | 0.000266728160103 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | signal transduction involved in DNA damage checkpoint |
| GO:0072401 | 0.000266728160103 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | signal transduction involved in DNA integrity checkpoint |
| CORUM:5544 | 0.000280879474705 | 0.133333333333 | CCNB1 CDK1 | CDC2-PCNA-CCNB1-GADD45A complex |
| CORUM:5546 | 0.000280879474705 | 0.133333333333 | CCNB1 CDK1 | CDC2-PCNA-CCNB1-GADD45G complex |
| CORUM:5545 | 0.000280879474705 | 0.133333333333 | CCNB1 CDK1 | CDC2-PCNA-CCNB1-GADD45B complex |
| GO:0072395 | 0.000287084512507 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | signal transduction involved in cell cycle checkpoint |
| GO:0071158 | 0.000355684051272 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | positive regulation of cell cycle arrest |
| GO:0045786 | 0.000357248925768 | 0.533333333333 | RBL2 CDKN1B GMNN CDK2 CDK1 RBL1 CCNB1 CDT1 | negative regulation of cell cycle |
| WP:WP366 | 0.000402438446937 | 0.266666666667 | CCNB2 CDK1 RBL1 RBL2 | TGF-beta Signaling Pathway |
| CORUM:3036 | 0.000467860031987 | 0.133333333333 | CKS1B SKP2 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) |
| WP:WP466 | 0.000640836321513 | 0.2 | CDK2 GMNN CDT1 | DNA Replication |
| GO:0071900 | 0.000651715518405 | 0.466666666667 | CCNE1 CDKN1B PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | regulation of protein serine/threonine kinase activity |
| WP:WP1971 | 0.000688482466207 | 0.2 | CDK2 CDK1 CDKN1B | Integrated Cancer Pathway |
| CORUM:6444 | 0.000701381656183 | 0.133333333333 | RBL2 RBL1 | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex |
| REAC:R-HSA-170145 | 0.000763046933764 | 0.133333333333 | CCNA2 CDK1 | Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes |
| GO:0000075 | 0.000877678117142 | 0.4 | RBL2 CDKN1B CDK2 CDK1 CCNB1 CDT1 | cell cycle checkpoint |
| GO:0044773 | 0.000919906414684 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | mitotic DNA damage checkpoint |
| REAC:R-HSA-3301854 | 0.00108277709149 | 0.2 | CCNB2 CDK1 CCNB1 | Nuclear Pore Complex (NPC) Disassembly |
| GO:1902494 | 0.00110169940671 | 0.666666666667 | SKP2 CKS2 CCNE1 CCNA2 CDK2 CDK1 CCNB1 CDKN1B CCNB2 CKS1B | catalytic complex |
| REAC:R-HSA-68962 | 0.00119033466003 | 0.2 | CDK2 GMNN CDT1 | Activation of the pre-replicative complex |
| GO:0071156 | 0.0012845870962 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | regulation of cell cycle arrest |
| GO:0030330 | 0.0012845870962 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | DNA damage response, signal transduction by p53 class mediator |
| REAC:R-HSA-6804757 | 0.00142619539443 | 0.2 | CDK2 CCNA2 CDK1 | Regulation of TP53 Degradation |
| GO:0061575 | 0.00144279242783 | 0.2 | CKS2 CKS1B CCNB1 | cyclin-dependent protein serine/threonine kinase activator activity |
| GO:0044774 | 0.00150565768226 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | mitotic DNA integrity checkpoint |
| REAC:R-HSA-69200 | 0.00152520574974 | 0.133333333333 | CDK2 CCNE1 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes |
| REAC:R-HSA-6806003 | 0.00155490877992 | 0.2 | CDK2 CCNA2 CDK1 | Regulation of TP53 Expression and Degradation |
| CORUM:1003 | 0.00168037910698 | 0.133333333333 | CDK2 CCNA2 | RC complex (Replication competent complex) |
| KEGG:05166 | 0.00193114785528 | 0.266666666667 | CCNB2 CDK2 CCNA2 CCNE1 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-68911 | 0.00254053028122 | 0.133333333333 | CDK2 CCNA2 | G2 Phase |
| REAC:R-HSA-2980766 | 0.0030734409473 | 0.2 | CCNB2 CDK1 CCNB1 | Nuclear Envelope Breakdown |
| REAC:R-HSA-9006927 | 0.00328587879893 | 0.2 | CDK2 CCNE1 CDKN1B | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 0.00328587879893 | 0.2 | CDK2 CCNE1 CDKN1B | Signaling by PTK6 |
| GO:0065009 | 0.00334765478095 | 0.733333333333 | RBL2 RBL1 CCNE1 GMNN PKMYT1 CDK1 CCNA2 CCNB1 CDKN1B CCNB2 CDT1 | regulation of molecular function |
| CORUM:1004 | 0.00363235504799 | 0.133333333333 | CDK2 CCNA2 | RC complex during S-phase of cell cycle |
| REAC:R-HSA-176417 | 0.00380857781046 | 0.133333333333 | CCNB1 CDK1 | Phosphorylation of Emi1 |
| GO:0042770 | 0.00387070881637 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | signal transduction in response to DNA damage |
| WP:WP2261 | 0.00482538818253 | 0.2 | CDK2 CCNE1 CDKN1B | Signaling Pathways in Glioblastoma |
| KEGG:05215 | 0.00492060244326 | 0.2 | CDK2 CCNE1 CDKN1B | Prostate cancer |
| GO:0000077 | 0.00607426704128 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | DNA damage checkpoint |
| WP:WP2431 | 0.00616162734528 | 0.2 | CDK2 CDK1 CDKN1B | Spinal Cord Injury |
| GO:0005654 | 0.00655743441911 | 0.866666666667 | RBL2 CCNE1 SKP2 CKS1B GMNN CDKN1B CDK2 PKMYT1 CDK1 CCNA2 RBL1 CCNB1 CDT1 | nucleoplasm |
| GO:0007077 | 0.00678530576901 | 0.2 | CCNB2 CDK1 CCNB1 | mitotic nuclear envelope disassembly |
| WP:WP1545 | 0.00682276728523 | 0.133333333333 | CCNE1 CDKN1B | miRNAs involved in DNA damage response |
| GO:0019901 | 0.00747972877784 | 0.466666666667 | CKS2 CDKN1B CCNE1 CCNA2 CCNB1 CCNB2 CKS1B | protein kinase binding |
| REAC:R-HSA-2559583 | 0.00809148192538 | 0.266666666667 | CDKN1B CDK2 CCNA2 CCNE1 | Cellular Senescence |
| CORUM:5614 | 0.00881207362225 | 0.133333333333 | RBL2 RBL1 | Emerin complex 32 |
| REAC:R-HSA-113507 | 0.00912463923681 | 0.133333333333 | CCNB1 CDK1 | E2F-enabled inhibition of pre-replication complex formation |
| GO:0042325 | 0.00914923189491 | 0.6 | RBL2 RBL1 CCNE1 CDKN1B PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | regulation of phosphorylation |
| KEGG:04151 | 0.00987139237413 | 0.266666666667 | RBL2 CDK2 CCNE1 CDKN1B | PI3K-Akt signaling pathway |
| WP:WP3640 | 0.00992440486013 | 0.133333333333 | CDKN1B SKP2 | Imatinib and Chronic Myeloid Leukemia |
| WP:WP4172 | 0.0107777790073 | 0.266666666667 | RBL2 CDK2 CCNE1 CDKN1B | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-2465910 | 0.011399162282 | 0.133333333333 | CCNB1 CDK1 | MASTL Facilitates Mitotic Progression |
| GO:0004672 | 0.0114201546299 | 0.466666666667 | CCNE1 CCNA2 CDK2 CDK1 PKMYT1 CCNB1 CCNB2 | protein kinase activity |
| GO:0051081 | 0.0117469826046 | 0.2 | CCNB2 CDK1 CCNB1 | nuclear envelope disassembly |
| GO:0030397 | 0.0117469826046 | 0.2 | CCNB2 CDK1 CCNB1 | membrane disassembly |
| GO:1901992 | 0.0118601785689 | 0.266666666667 | CCNB1 CDT1 CCNE1 CDK1 | positive regulation of mitotic cell cycle phase transition |
| REAC:R-HSA-69017 | 0.0121861122868 | 0.2 | CDK2 CCNA2 CCNE1 | CDK-mediated phosphorylation and removal of Cdc6 |
| REAC:R-HSA-176409 | 0.0137961647736 | 0.2 | CCNB1 CCNA2 CDK1 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| KEGG:05162 | 0.0139732163913 | 0.2 | CDK2 CCNE1 CDKN1B | Measles |
| REAC:R-HSA-176814 | 0.0143623112133 | 0.2 | CCNB1 CCNA2 CDK1 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-8852276 | 0.0149434975051 | 0.2 | CCNB2 CDK1 CCNB1 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| KEGG:05226 | 0.0149598607597 | 0.2 | CDK2 CCNE1 CDKN1B | Gastric cancer |
| GO:0045859 | 0.0163481446133 | 0.466666666667 | CCNE1 CDKN1B PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | regulation of protein kinase activity |
| MIRNA:hsa-miR-892b | 0.0164171550085 | 0.2 | RBL1 CCNE1 CDK2 | hsa-miR-892b |
| REAC:R-HSA-4419969 | 0.0166993211532 | 0.133333333333 | CCNB1 CDK1 | Depolymerisation of the Nuclear Lamina |
| GO:0019900 | 0.0176584807084 | 0.466666666667 | CKS2 CDKN1B CCNE1 CCNA2 CCNB1 CCNB2 CKS1B | kinase binding |
| WP:WP2877 | 0.0176765277107 | 0.2 | CDK2 CCNE1 CDKN1B | Vitamin D Receptor Pathway |
| KEGG:04934 | 0.0185718464011 | 0.2 | CDK2 CCNE1 CDKN1B | Cushing syndrome |
| REAC:R-HSA-75035 | 0.0197240784864 | 0.133333333333 | CCNB1 CDK1 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| REAC:R-HSA-2565942 | 0.0201564623878 | 0.2 | CCNB2 CDK1 CCNB1 | Regulation of PLK1 Activity at G2/M Transition |
| HPA:048040_23 | 0.0206088024907 | 0.2 | CKS2 CDT1 CKS1B | soft tissue 2; peripheral nerve[Approved,High] |
| REAC:R-HSA-69002 | 0.0208812525558 | 0.2 | CDK2 GMNN CDT1 | DNA Replication Pre-Initiation |
| GO:0019220 | 0.0221013453005 | 0.6 | RBL2 RBL1 CCNE1 CDKN1B PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | regulation of phosphate metabolic process |
| GO:0051174 | 0.0222596907076 | 0.6 | RBL2 RBL1 CCNE1 CDKN1B PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | regulation of phosphorus metabolic process |
| GO:0016310 | 0.0238199083439 | 0.666666666667 | RBL2 RBL1 CCNE1 CDKN1B CDK2 PKMYT1 CDK1 CCNA2 CCNB1 CCNB2 | phosphorylation |
| KEGG:05161 | 0.0245106244433 | 0.2 | CDK2 CCNA2 CCNE1 | Hepatitis B |
| GO:1901989 | 0.02458972876 | 0.266666666667 | CCNB1 CDT1 CCNE1 CDK1 | positive regulation of cell cycle phase transition |
| KEGG:00000 | 0.0252253336476 | 0.866666666667 | RBL2 SKP2 RBL1 CKS2 CCNE1 CCNA2 CDK2 CDK1 PKMYT1 CCNB1 CDKN1B CCNB2 CKS1B | KEGG root term |
| MIRNA:hsa-miR-24-3p | 0.0256655238525 | 0.4 | CDKN1B CCNA2 CDK1 PKMYT1 RBL1 CCNB1 | hsa-miR-24-3p |
| MIRNA:hsa-miR-212-3p | 0.0300754797928 | 0.2 | CCNB1 CCNA2 GMNN | hsa-miR-212-3p |
| HPA:027020_23 | 0.0304837670928 | 0.266666666667 | CKS2 CDT1 CDKN1B CKS1B | lung; pneumocytes[Approved,High] |
| HP:0009892 | 0.0336546695944 | 0.133333333333 | GMNN CDT1 | Anotia |
| HP:0011267 | 0.0336546695944 | 0.133333333333 | GMNN CDT1 | Microtia, third degree |
| REAC:R-HSA-9617828 | 0.0343107362007 | 0.133333333333 | RBL2 CDKN1B | FOXO-mediated transcription of cell cycle genes |
| GO:0016773 | 0.0360229728832 | 0.466666666667 | CCNE1 CCNA2 CDK2 CDK1 PKMYT1 CCNB1 CCNB2 | phosphotransferase activity, alcohol group as acceptor |
| MIRNA:hsa-miR-193b-3p | 0.0361092717262 | 0.4 | GMNN CCNA2 CDK1 PKMYT1 RBL1 CDT1 | hsa-miR-193b-3p |
| MIRNA:hsa-miR-4667-5p | 0.037131888202 | 0.2 | CDT1 CDKN1B PKMYT1 | hsa-miR-4667-5p |
| REAC:R-HSA-8878166 | 0.0380589147813 | 0.2 | CCNB1 CDK1 SKP2 | Transcriptional regulation by RUNX2 |
| REAC:R-HSA-176412 | 0.0385771221176 | 0.133333333333 | CCNB1 CDK1 | Phosphorylation of the APC/C |
| REAC:R-HSA-2559582 | 0.0402706236184 | 0.2 | CDK2 CCNA2 CDKN1B | Senescence-Associated Secretory Phenotype (SASP) |
| HPA:024010_23 | 0.0406865088166 | 0.266666666667 | CKS2 CDT1 CDKN1B CKS1B | kidney; cells in glomeruli[Approved,High] |
| MIRNA:hsa-miR-4700-5p | 0.0410328798164 | 0.2 | CDT1 CDKN1B PKMYT1 | hsa-miR-4700-5p |
| HP:0009939 | 0.0411095510007 | 0.133333333333 | GMNN CDT1 | Mandibular aplasia |
| GO:0007050 | 0.0422666557867 | 0.333333333333 | CCNB1 CDK2 RBL2 CDK1 CDKN1B | cell cycle arrest |
| REAC:R-HSA-1362277 | 0.0430905242414 | 0.133333333333 | RBL2 RBL1 | Transcription of E2F targets under negative control by DREAM complex |
| MIRNA:hsa-miR-8089 | 0.0451926825894 | 0.2 | CDT1 CDKN1B PKMYT1 | hsa-miR-8089 |
| GO:0097125 | 0.0473364581948 | 0.133333333333 | CCNB1 CDK1 | cyclin B1-CDK1 complex |
| CORUM:7185 | 0.0498572752401 | 0.0666666666667 | CCNB1 | CCNB1-CCNF complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCNA2 | CDK2 | 1.0 | 0.949 | hein_WMM bioplex (CCNA2,CDK2) bioplex_WMM boldt hein (CCNA2,CDK2) gupta_WMM boldt_WMM |
| CCNE1 | CDK2 | 1.0 | 0.949 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) |
| CCNB1 | CDK1 | 1.0 | 0.949 | hein_WMM bioplex (CDK1) bioplex_WMM Guru hein (CCNB1,CDK1) gupta_WMM fraction boldt_WMM |
| CCNB2 | CDK1 | 1.0 | 0.949 | hein_WMM bioplex (CDK1) bioplex_WMM Guru hein (CCNB2,CDK1) gupta_WMM fraction |
| CKS2 | CDK1 | 1.0 | 0.949 | hein_WMM bioplex (CDK1,CKS2) bioplex_WMM Guru hein (CDK1) fraction |
| GMNN | CDT1 | 1.0 | 0.949 | hein_WMM bioplex (GMNN) bioplex_WMM hein (CDT1,GMNN) |
| CDKN1B | CDK2 | 0.999 | 0.949 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) gupta_WMM |
| SKP2 | CDK2 | 0.996 | 0.927 | hein_WMM bioplex (CDK2,SKP2) bioplex_WMM youn_WMM hein (CDK2) |
| CDK1 | CKS1B | 0.996 | 0.926 | hein_WMM bioplex (CDK1,CKS1B) bioplex_WMM Guru hein (CDK1) gupta_WMM fraction |
| CCNA2 | RBL1 | 0.989 | 0.903 | bioplex (CCNA2) bioplex_WMM boldt boldt_WMM |
| RBL1 | CDK2 | 0.988 | 0.902 | bioplex (CDK2) bioplex_WMM boldt boldt_WMM |
| CCNA2 | PKMYT1 | 0.973 | 0.886 | hein_WMM bioplex (CCNA2) bioplex_WMM hein (CCNA2) |
| CCNB1 | CDK2 | 0.969 | 0.88 | hein_WMM bioplex (CDK2) bioplex_WMM youn_WMM hein (CDK2) gupta_WMM |
| CCNA2 | CKS1B | 0.966 | 0.876 | hein_WMM bioplex (CCNA2,CKS1B) bioplex_WMM hein (CCNA2) |
| CKS1B | SKP2 | 0.96 | 0.865 | hein_WMM bioplex (CKS1B) bioplex_WMM youn_WMM |
| CCNA2 | SKP2 | 0.959 | 0.865 | hein_WMM bioplex (CCNA2) bioplex_WMM hein (CCNA2) |
| CCNA2 | CDK1 | 0.957 | 0.863 | hein_WMM bioplex (CCNA2,CDK1) bioplex_WMM hein (CCNA2,CDK1) gupta_WMM |
| CCNA2 | GMNN | 0.926 | 0.844 | hein_WMM bioplex (CCNA2,GMNN) bioplex_WMM boldt hein (CCNA2,GMNN) boldt_WMM |
| CKS1B | CDK2 | 0.906 | 0.83 | hein_WMM bioplex (CDK2,CKS1B) bioplex_WMM youn_WMM hein (CDK2) gupta_WMM fraction |
| CCNA2 | CDT1 | 0.89 | 0.818 | hein_WMM bioplex (CCNA2) bioplex_WMM hein (CCNA2,CDT1) |
| CCNB1 | CKS1B | 0.815 | 0.773 | hein_WMM bioplex (CKS1B) bioplex_WMM youn_WMM hein (CCNB1) |
| CCNA2 | CDKN1B | 0.797 | 0.763 | hein_WMM bioplex (CCNA2) bioplex_WMM hein (CCNA2) |
| CCNB1 | CKS2 | 0.765 | 0.749 | hein_WMM bioplex (CKS2) bioplex_WMM youn_WMM hein (CCNB1) |
| CCNA2 | RBL2 | 0.704 | 0.725 | bioplex (CCNA2) bioplex_WMM boldt_WMM |
| RBL2 | CDK2 | 0.667 | 0.701 | bioplex (CDK2) bioplex_WMM boldt_WMM |
| CDK1 | PKMYT1 | 0.462 | 0.6 | hein_WMM bioplex (CDK1) bioplex_WMM hein (CDK1) gupta_WMM |
| CCNB2 | CKS1B | 0.403 | 0.562 | hein_WMM bioplex (CKS1B) bioplex_WMM youn_WMM gupta_WMM |
| PKMYT1 | CKS1B | 0.348 | 0.536 | hein_WMM bioplex (CKS1B) bioplex_WMM |
| CKS1B | CDT1 | 0.322 | 0.511 | hein_WMM bioplex (CKS1B) bioplex_WMM |
| CCNB2 | CKS2 | 0.229 | 0.468 | hein_WMM bioplex (CKS2) bioplex_WMM youn_WMM |
| CDK1 | SKP2 | 0.219 | 0.466 | hein_WMM bioplex (CDK1,SKP2) bioplex_WMM hein (CDK1) |
| GMNN | CKS1B | 0.134 | 0.406 | hein_WMM bioplex (CKS1B,GMNN) bioplex_WMM hein (GMNN) |
| CKS2 | CDK2 | 0.13 | 0.4 | hein_WMM bioplex (CDK2,CKS2) bioplex_WMM youn_WMM hein (CDK2) |
| CCNA2 | CKS2 | 0.115 | 0.385 | hein_WMM bioplex (CCNA2,CKS2) bioplex_WMM |
| CKS2 | CDKN1B | 0.072 | 0.356 | hein_WMM bioplex (CKS2) bioplex_WMM |
| CKS2 | CDT1 | 0.063 | 0.348 | bioplex (CKS2) bioplex_WMM |
| GMNN | SKP2 | 0.059 | 0.333 | hein_WMM bioplex (GMNN) bioplex_WMM hein (GMNN) |
| CDKN1B | CKS1B | 0.056 | 0.312 | hein_WMM bioplex (CKS1B) bioplex_WMM |
| CKS2 | CKS1B | 0.053 | 0.302 | hein_WMM bioplex (CKS1B) bioplex_WMM youn_WMM |
| CKS2 | CCNE1 | 0.052 | 0.299 | hein_WMM bioplex (CKS2) bioplex_WMM |
| CCNB1 | CDKN1B | 0.052 | 0.301 | hein_WMM bioplex_WMM hein (CCNB1) |
| CCNE1 | CKS1B | 0.043 | 0.272 | hein_WMM bioplex (CKS1B) bioplex_WMM |
| CCNB2 | PKMYT1 | 0.043 | 0.272 | hein_WMM bioplex_WMM hein (CCNB2) |
| CCNB1 | PKMYT1 | 0.037 | 0.268 | hein_WMM bioplex_WMM hein (CCNB1) gupta_WMM |
| CKS2 | PKMYT1 | 0.036 | 0.266 | hein_WMM bioplex (CKS2) bioplex_WMM |
| CKS2 | GMNN | 0.021 | 0.185 | bioplex (CKS2,GMNN) bioplex_WMM |
| CCNA2 | CCNE1 | 0.019 | 0.183 | hein_WMM bioplex_WMM WMM_only |
| GMNN | CDK2 | 0.018 | 0.18 | hein_WMM bioplex (CDK2,GMNN) bioplex_WMM boldt boldt_WMM |
| CCNB1 | CCNB2 | 0.017 | 0.174 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| CCNE1 | CDKN1B | 0.015 | 0.152 | hein_WMM bioplex_WMM WMM_only |
| CKS2 | SKP2 | 0.015 | 0.143 | hein_WMM bioplex_WMM WMM_only |
| CCNB1 | CCNE1 | 0.014 | 0.138 | hein_WMM bioplex_WMM WMM_only |
| CDKN1B | CDT1 | 0.013 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| PKMYT1 | CDT1 | 0.012 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| CCNB1 | CCNA2 | 0.012 | 0.152 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| RBL2 | RBL1 | 0.011 | 0.149 | bioplex_WMM WMM_only boldt_WMM |
| CDKN1B | RBL2 | 0.011 | 0.138 | bioplex_WMM WMM_only |
| CDKN1B | SKP2 | 0.011 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| CDKN1B | PKMYT1 | 0.011 | 0.144 | hein_WMM bioplex_WMM WMM_only |
| GMNN | CDKN1B | 0.01 | 0.139 | hein_WMM bioplex_WMM WMM_only |
| CCNE1 | CDT1 | 0.01 | 0.126 | bioplex_WMM WMM_only |
| CCNE1 | SKP2 | 0.01 | 0.116 | hein_WMM bioplex_WMM WMM_only |
| CCNB2 | CCNA2 | 0.01 | 0.106 | hein_WMM bioplex_WMM WMM_only |
| CCNB1 | CDT1 | 0.01 | 0.097 | bioplex_WMM WMM_only |
| CCNE1 | GMNN | 0.01 | 0.099 | bioplex_WMM WMM_only |
| CCNB2 | CDT1 | 0.01 | 0.104 | bioplex_WMM WMM_only |
| CCNB2 | CDKN1B | 0.009 | 0.114 | bioplex_WMM WMM_only |
| GMNN | PKMYT1 | 0.009 | 0.115 | hein_WMM bioplex_WMM WMM_only |
| CCNB2 | CCNE1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| CDK1 | RBL2 | 0.009 | 0.105 | bioplex_WMM WMM_only |
| CCNB2 | GMNN | 0.009 | 0.102 | bioplex_WMM WMM_only |
| PKMYT1 | SKP2 | 0.009 | 0.098 | hein_WMM bioplex_WMM WMM_only |
| PKMYT1 | CDK2 | 0.009 | 0.096 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| CCNB1 | GMNN | 0.009 | 0.095 | bioplex_WMM WMM_only |
| CDK1 | CDK2 | 0.008 | 0.087 | hein_WMM bioplex (CDK1,CDK2) bioplex_WMM gupta_WMM |
| CKS1B | RBL1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| CCNE1 | PKMYT1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| RBL2 | CKS1B | 0.008 | 0.081 | bioplex_WMM WMM_only |
| CKS2 | RBL1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SKP2 | RBL1 | 0.008 | 0.071 | bioplex_WMM WMM_only |
| CCNE1 | CDK1 | 0.008 | 0.07 | bioplex_WMM WMM_only |
| CDKN1B | RBL1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| CKS2 | RBL2 | 0.008 | 0.053 | bioplex_WMM WMM_only |
| RBL2 | SKP2 | 0.008 | 0.047 | bioplex_WMM WMM_only |
| GMNN | RBL1 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| CCNE1 | RBL1 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| GMNN | RBL2 | 0.008 | 0.023 | bioplex_WMM WMM_only |
| CCNE1 | RBL2 | 0.008 | 0.015 | bioplex_WMM WMM_only |
| CCNB2 | RBL1 | 0.008 | 0.014 | bioplex_WMM WMM_only |
| CCNB2 | RBL2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| RBL1 | CDT1 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| PKMYT1 | RBL1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| RBL2 | CDT1 | 0.007 | 0.012 | bioplex_WMM WMM_only |
| CDK1 | RBL1 | 0.007 | 0.01 | bioplex_WMM gupta_WMM WMM_only |
| CCNB1 | RBL1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| PKMYT1 | RBL2 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| CCNB1 | RBL2 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| SKP2 | CDT1 | 0.005 | 0.008 | hein_WMM bioplex_WMM hein (CDT1) |
| CDK1 | CDT1 | 0.005 | 0.006 | hein_WMM bioplex (CDK1) bioplex_WMM |
| CDK1 | CDKN1B | 0.003 | 0.013 | hein_WMM bioplex (CDK1) bioplex_WMM gupta_WMM |
| CCNB2 | SKP2 | 0.003 | 0.007 | hein_WMM bioplex_WMM fraction |
| CCNB2 | CDK2 | 0.0 | 0.011 | bioplex (CDK2) bioplex_WMM youn_WMM gupta_WMM |
| CDT1 | CDK2 | 0.0 | 0.014 | hein_WMM bioplex_WMM hein (CDT1) |
| CDK1 | GMNN | 0.0 | 0.012 | hein_WMM bioplex (CDK1,GMNN) bioplex_WMM |
| CCNB1 | SKP2 | 0.0 | 0.012 | hein_WMM bioplex_WMM fraction |
Images
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Complex HuMAP2_01003 has an average edge precision of 0.325 which is ranked 4276 out of all 6965 complexes.
Related Complexes