hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01010
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDK1 | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | UniProt NCBI |
| CKS1B | Cyclin-dependent kinases regulatory subunit 1 (CKS-1) | UniProt NCBI |
| CCNB1 | G2/mitotic-specific cyclin-B1 | UniProt NCBI |
| CCNB2 | G2/mitotic-specific cyclin-B2 | UniProt NCBI |
| CKS2 | Cyclin-dependent kinases regulatory subunit 2 (CKS-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000307 | 2.6593619452e-09 | 1.0 | CCNB2 CDK1 CCNB1 CKS1B CKS2 | cyclin-dependent protein kinase holoenzyme complex |
| CORUM:310 | 2.70211703843e-08 | 0.6 | CCNB2 CCNB1 CDK1 | Cell cycle kinase complex CDC2 |
| REAC:R-HSA-69478 | 2.7185712528e-08 | 0.6 | CCNB2 CCNB1 CDK1 | G2/M DNA replication checkpoint |
| REAC:R-HSA-2980767 | 9.51308232652e-08 | 0.6 | CCNB2 CCNB1 CDK1 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| GO:1902554 | 1.31961833602e-07 | 1.0 | CCNB2 CDK1 CCNB1 CKS1B CKS2 | serine/threonine protein kinase complex |
| GO:1902911 | 3.20924936678e-07 | 1.0 | CCNB2 CDK1 CCNB1 CKS1B CKS2 | protein kinase complex |
| REAC:R-HSA-2514853 | 4.48293159034e-07 | 0.6 | CCNB2 CCNB1 CDK1 | Condensation of Prometaphase Chromosomes |
| REAC:R-HSA-162658 | 7.76884875116e-07 | 0.6 | CCNB2 CCNB1 CDK1 | Golgi Cisternae Pericentriolar Stack Reorganization |
| REAC:R-HSA-69273 | 6.24012216224e-06 | 0.6 | CCNB2 CCNB1 CDK1 | Cyclin A/B1/B2 associated events during G2/M transition |
| CORUM:5550 | 6.70868171695e-06 | 0.4 | CDK1 CCNB1 | CDK1-CCNB1-CCNF complex |
| CORUM:5543 | 6.70868171695e-06 | 0.4 | CDK1 CCNB1 | CCNB1-CDC2 complex |
| CORUM:5542 | 6.70868171695e-06 | 0.4 | CCNB2 CDK1 | CCNB2-CDC2 complex |
| GO:0016538 | 8.04174090024e-06 | 0.8 | CCNB2 CCNB1 CKS1B CKS2 | cyclin-dependent protein serine/threonine kinase regulator activity |
| REAC:R-HSA-3301854 | 1.34474619847e-05 | 0.6 | CCNB2 CCNB1 CDK1 | Nuclear Pore Complex (NPC) Disassembly |
| CORUM:5551 | 2.0123342217e-05 | 0.4 | CDK1 CCNB1 | CDC2-CCNB1-PTCH1 complex |
| CORUM:243 | 2.0123342217e-05 | 0.4 | CDK1 CCNB1 | RalBP1-CDC2-CCNB1 complex |
| GO:0061575 | 3.17736949706e-05 | 0.6 | CKS2 CCNB1 CKS1B | cyclin-dependent protein serine/threonine kinase activator activity |
| WP:WP707 | 3.20197280625e-05 | 0.6 | CCNB2 CCNB1 CDK1 | DNA Damage Response |
| KEGG:04115 | 3.58157342459e-05 | 0.6 | CCNB2 CCNB1 CDK1 | p53 signaling pathway |
| GO:0061695 | 3.59850228871e-05 | 1.0 | CCNB2 CDK1 CCNB1 CKS1B CKS2 | transferase complex, transferring phosphorus-containing groups |
| WP:WP1530 | 3.65771562028e-05 | 0.6 | CCNB2 CCNB1 CDK1 | miRNA Regulation of DNA Damage Response |
| REAC:R-HSA-2980766 | 3.84212387398e-05 | 0.6 | CCNB2 CCNB1 CDK1 | Nuclear Envelope Breakdown |
| CORUM:5544 | 4.0241279111e-05 | 0.4 | CDK1 CCNB1 | CDC2-PCNA-CCNB1-GADD45A complex |
| CORUM:5545 | 4.0241279111e-05 | 0.4 | CDK1 CCNB1 | CDC2-PCNA-CCNB1-GADD45B complex |
| CORUM:5546 | 4.0241279111e-05 | 0.4 | CDK1 CCNB1 | CDC2-PCNA-CCNB1-GADD45G complex |
| WP:WP2446 | 7.07040269841e-05 | 0.6 | CCNB2 CCNB1 CDK1 | Retinoblastoma Gene in Cancer |
| KEGG:04914 | 7.32179527008e-05 | 0.6 | CCNB2 CCNB1 CDK1 | Progesterone-mediated oocyte maturation |
| GO:0007077 | 0.000149729915117 | 0.6 | CCNB2 CCNB1 CDK1 | mitotic nuclear envelope disassembly |
| WP:WP179 | 0.000168575165363 | 0.6 | CCNB2 CCNB1 CDK1 | Cell Cycle |
| KEGG:04114 | 0.000169883843985 | 0.6 | CCNB2 CCNB1 CDK1 | Oocyte meiosis |
| REAC:R-HSA-8852276 | 0.000189751148448 | 0.6 | CCNB2 CCNB1 CDK1 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-176417 | 0.000202356855584 | 0.4 | CDK1 CCNB1 | Phosphorylation of Emi1 |
| KEGG:04110 | 0.000240055495634 | 0.6 | CCNB2 CCNB1 CDK1 | Cell cycle |
| REAC:R-HSA-2565942 | 0.00025697910325 | 0.6 | CCNB2 CCNB1 CDK1 | Regulation of PLK1 Activity at G2/M Transition |
| GO:0030397 | 0.000259479548289 | 0.6 | CCNB2 CCNB1 CDK1 | membrane disassembly |
| GO:0051081 | 0.000259479548289 | 0.6 | CCNB2 CCNB1 CDK1 | nuclear envelope disassembly |
| KEGG:04218 | 0.000424294655338 | 0.6 | CCNB2 CCNB1 CDK1 | Cellular senescence |
| REAC:R-HSA-113507 | 0.000485460775426 | 0.4 | CDK1 CCNB1 | E2F-enabled inhibition of pre-replication complex formation |
| CORUM:1005 | 0.000522504524138 | 0.4 | CDK1 CCNB1 | RC complex during G2/M-phase of cell cycle |
| REAC:R-HSA-2465910 | 0.000606744453221 | 0.4 | CDK1 CCNB1 | MASTL Facilitates Mitotic Progression |
| REAC:R-HSA-2500257 | 0.000754665480287 | 0.6 | CCNB2 CCNB1 CDK1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-4419969 | 0.000889652787086 | 0.4 | CDK1 CCNB1 | Depolymerisation of the Nuclear Lamina |
| REAC:R-HSA-69206 | 0.000960389260783 | 0.6 | CDK1 CCNB1 CKS1B | G1/S Transition |
| REAC:R-HSA-68875 | 0.00100555265154 | 0.6 | CCNB2 CCNB1 CDK1 | Mitotic Prophase |
| REAC:R-HSA-69278 | 0.00103692271301 | 0.8 | CCNB2 CCNB1 CKS1B CDK1 | Cell Cycle, Mitotic |
| REAC:R-HSA-75035 | 0.00105126658749 | 0.4 | CDK1 CCNB1 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| KEGG:05170 | 0.00109699385517 | 0.6 | CCNB2 CCNB1 CDK1 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-453279 | 0.00138993331814 | 0.6 | CDK1 CCNB1 CKS1B | Mitotic G1-G1/S phases |
| REAC:R-HSA-156711 | 0.00161668141155 | 0.4 | CCNB2 CCNB1 | Polo-like kinase mediated events |
| GO:0019887 | 0.0016512304967 | 0.8 | CCNB2 CCNB1 CKS1B CKS2 | protein kinase regulator activity |
| REAC:R-HSA-69481 | 0.00203883898451 | 0.6 | CCNB2 CCNB1 CDK1 | G2/M Checkpoints |
| REAC:R-HSA-6804114 | 0.00206071490935 | 0.4 | CDK1 CCNB1 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| REAC:R-HSA-176412 | 0.00206071490935 | 0.4 | CDK1 CCNB1 | Phosphorylation of the APC/C |
| REAC:R-HSA-1640170 | 0.0021256129161 | 0.8 | CCNB2 CCNB1 CKS1B CDK1 | Cell Cycle |
| WP:WP2516 | 0.00246224573223 | 0.4 | CDK1 CCNB1 | ATM Signaling Pathway |
| REAC:R-HSA-69275 | 0.00300215492023 | 0.6 | CCNB2 CCNB1 CDK1 | G2/M Transition |
| GO:0019207 | 0.00302325172609 | 0.8 | CCNB2 CCNB1 CKS1B CKS2 | kinase regulator activity |
| REAC:R-HSA-68877 | 0.00304975168622 | 0.6 | CCNB2 CCNB1 CDK1 | Mitotic Prometaphase |
| REAC:R-HSA-453274 | 0.00309784557874 | 0.6 | CCNB2 CCNB1 CDK1 | Mitotic G2-G2/M phases |
| REAC:R-HSA-174048 | 0.0031096034254 | 0.4 | CDK1 CCNB1 | APC/C:Cdc20 mediated degradation of Cyclin B |
| REAC:R-HSA-113510 | 0.0031096034254 | 0.4 | CDK1 CCNB1 | E2F mediated regulation of DNA replication |
| GO:0097125 | 0.00450823411379 | 0.4 | CDK1 CCNB1 | cyclin B1-CDK1 complex |
| WP:WP45 | 0.00646864373199 | 0.4 | CDK1 CCNB1 | G1 to S cell cycle control |
| GO:0006998 | 0.00893946499793 | 0.6 | CCNB2 CCNB1 CDK1 | nuclear envelope organization |
| REAC:R-HSA-69620 | 0.0103005771752 | 0.6 | CCNB2 CCNB1 CDK1 | Cell Cycle Checkpoints |
| GO:1990234 | 0.0112296002627 | 1.0 | CCNB2 CDK1 CCNB1 CKS1B CKS2 | transferase complex |
| WP:WP4658 | 0.0147251965341 | 0.4 | CKS2 CKS1B | Small cell lung cancer |
| REAC:R-HSA-6791312 | 0.0151315666639 | 0.4 | CDK1 CCNB1 | TP53 Regulates Transcription of Cell Cycle Genes |
| KEGG:05222 | 0.0177565608839 | 0.4 | CKS2 CKS1B | Small cell lung cancer |
| REAC:R-HSA-68886 | 0.0231915667986 | 0.6 | CCNB2 CCNB1 CDK1 | M Phase |
| CORUM:7185 | 0.0249780992026 | 0.2 | CCNB1 | CCNB1-CCNF complex |
| WP:WP366 | 0.0250517914711 | 0.4 | CCNB2 CDK1 | TGF-beta Signaling Pathway |
| GO:0000278 | 0.02689008569 | 1.0 | CCNB2 CDK1 CCNB1 CKS1B CKS2 | mitotic cell cycle |
| GO:1905448 | 0.0270421395626 | 0.4 | CDK1 CCNB1 | positive regulation of mitochondrial ATP synthesis coupled electron transport |
| KEGG:04068 | 0.0272411437938 | 0.4 | CCNB2 CCNB1 | FoxO signaling pathway |
| GO:0030295 | 0.0293579111372 | 0.6 | CKS2 CCNB1 CKS1B | protein kinase activator activity |
| REAC:R-HSA-2299718 | 0.0341769281663 | 0.4 | CDK1 CCNB1 | Condensation of Prophase Chromosomes |
| GO:0019209 | 0.0358473364726 | 0.6 | CKS2 CCNB1 CKS1B | kinase activator activity |
| REAC:R-HSA-176409 | 0.0361060371214 | 0.4 | CDK1 CCNB1 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-176814 | 0.0370902496619 | 0.4 | CDK1 CCNB1 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| GO:0051726 | 0.0398642747089 | 1.0 | CCNB2 CDK1 CCNB1 CKS1B CKS2 | regulation of cell cycle |
| REAC:R-HSA-176408 | 0.0411580285567 | 0.4 | CDK1 CCNB1 | Regulation of APC/C activators between G1/S and early anaphase |
| HPA:014010_23 | 0.0430128383603 | 0.4 | CKS2 CKS1B | endometrium 2; cells in endometrial stroma[Approved,High] |
| GO:1905446 | 0.0450641792523 | 0.4 | CDK1 CCNB1 | regulation of mitochondrial ATP synthesis coupled electron transport |
| REAC:R-HSA-174143 | 0.0476518941102 | 0.4 | CDK1 CCNB1 | APC/C-mediated degradation of cell cycle proteins |
| REAC:R-HSA-453276 | 0.0476518941102 | 0.4 | CDK1 CCNB1 | Regulation of mitotic cell cycle |
| HPA:047040_23 | 0.0484895361996 | 0.4 | CKS2 CKS1B | soft tissue 1; peripheral nerve[Approved,High] |
| HPA:048040_23 | 0.0496237822589 | 0.4 | CKS2 CKS1B | soft tissue 2; peripheral nerve[Approved,High] |
| CORUM:5557 | 0.0499494897235 | 0.2 | CDK1 | CDC2-CCNA2 complex |
| CORUM:5643 | 0.0499494897235 | 0.2 | CDK1 | ESPL1-CDC2 complex |
| CORUM:5319 | 0.0499494897235 | 0.2 | CKS1B | CDH1-CKS1B complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCNB1 | CDK1 | 1.0 | 0.949 | hein_WMM bioplex (CDK1) bioplex_WMM Guru hein (CCNB1,CDK1) gupta_WMM fraction boldt_WMM |
| CCNB2 | CDK1 | 1.0 | 0.949 | hein_WMM bioplex (CDK1) bioplex_WMM Guru hein (CCNB2,CDK1) gupta_WMM fraction |
| CKS2 | CDK1 | 1.0 | 0.949 | hein_WMM bioplex (CDK1,CKS2) bioplex_WMM Guru hein (CDK1) fraction |
| CDK1 | CKS1B | 0.996 | 0.926 | hein_WMM bioplex (CDK1,CKS1B) bioplex_WMM Guru hein (CDK1) gupta_WMM fraction |
| CCNB1 | CKS1B | 0.815 | 0.773 | hein_WMM bioplex (CKS1B) bioplex_WMM youn_WMM hein (CCNB1) |
| CCNB1 | CKS2 | 0.765 | 0.749 | hein_WMM bioplex (CKS2) bioplex_WMM youn_WMM hein (CCNB1) |
| CCNB2 | CKS1B | 0.403 | 0.562 | hein_WMM bioplex (CKS1B) bioplex_WMM youn_WMM gupta_WMM |
| CCNB2 | CKS2 | 0.229 | 0.468 | hein_WMM bioplex (CKS2) bioplex_WMM youn_WMM |
| CKS2 | CKS1B | 0.053 | 0.302 | hein_WMM bioplex (CKS1B) bioplex_WMM youn_WMM |
| CCNB1 | CCNB2 | 0.017 | 0.174 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_01010 has an average edge precision of 0.68 which is ranked 1461 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDK1 | HuMAP2_01003 HuMAP2_01010 HuMAP2_02530 |
| CKS1B | HuMAP2_01003 HuMAP2_01010 HuMAP2_02530 |
| CCNB1 | HuMAP2_00550 HuMAP2_01003 HuMAP2_01010 HuMAP2_02530 HuMAP2_05166 |
| CCNB2 | HuMAP2_00557 HuMAP2_01003 HuMAP2_01010 HuMAP2_02530 HuMAP2_04188 |
| CKS2 | HuMAP2_01003 HuMAP2_01010 HuMAP2_02530 |