hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01017
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| H3C1 | Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l) | UniProt NCBI |
| HIRA | Protein HIRA (TUP1-like enhancer of split protein 1) | UniProt NCBI |
| ASF1A | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | UniProt NCBI |
| IPO4 | Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) | UniProt NCBI |
| TONSL | Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2) | UniProt NCBI |
| PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) | UniProt NCBI |
| CDAN1 | Codanin-1 | UniProt NCBI |
| CABIN1 | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | UniProt NCBI |
| UBN2 | Ubinuclein-2 | UniProt NCBI |
| CDX1 | Homeobox protein CDX-1 (Caudal-type homeobox protein 1) | UniProt NCBI |
| UBN1 | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | UniProt NCBI |
| ASF1B | Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II) | UniProt NCBI |
| PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) | UniProt NCBI |
| C15orf41 | Uncharacterized protein C15orf41 (Protein HH114) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1150 | 6.98297487258e-10 | 0.307692307692 | ASF1A ASF1B HIRA IPO4 | Histone H3.3 complex |
| CORUM:6149 | 2.97527064635e-08 | 0.230769230769 | ASF1A CDAN1 IPO4 | Codanin-1-Asf1-histone H3.1-histone H4-importin-4 complex, cytosolic |
| CORUM:7382 | 1.1895088487e-07 | 0.230769230769 | UBN1 HIRA CABIN1 | Prohibitin-HIRA complex |
| CORUM:7383 | 1.1895088487e-07 | 0.230769230769 | UBN1 HIRA CABIN1 | OGT-HIRA complex |
| GO:0006336 | 1.43500372005e-07 | 0.461538461538 | UBN1 CABIN1 ASF1B ASF1A IPO4 HIRA | DNA replication-independent nucleosome assembly |
| REAC:R-HSA-2559584 | 1.510152609e-07 | 0.307692307692 | ASF1A UBN1 HIRA CABIN1 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
| GO:0034724 | 1.61006775474e-07 | 0.461538461538 | UBN1 CABIN1 ASF1B ASF1A IPO4 HIRA | DNA replication-independent nucleosome organization |
| CORUM:2235 | 2.97227432175e-07 | 0.230769230769 | ASF1A HIRA ASF1B | ASF1-interacting protein complex |
| GO:0031497 | 3.91229400986e-07 | 0.538461538462 | UBN1 ASF1B IPO4 CABIN1 ASF1A CDAN1 HIRA | chromatin assembly |
| GO:0006333 | 9.8329603123e-07 | 0.538461538462 | UBN1 ASF1B IPO4 CABIN1 ASF1A CDAN1 HIRA | chromatin assembly or disassembly |
| CORUM:1149 | 1.66195974904e-06 | 0.230769230769 | ASF1A IPO4 ASF1B | Histone H3.1 complex |
| GO:0006323 | 1.80608651226e-06 | 0.538461538462 | UBN1 ASF1B IPO4 CABIN1 ASF1A CDAN1 HIRA | DNA packaging |
| GO:0006334 | 1.04022726943e-05 | 0.461538461538 | UBN1 CABIN1 ASF1B ASF1A IPO4 HIRA | nucleosome assembly |
| GO:0071103 | 1.71081591854e-05 | 0.538461538462 | UBN1 ASF1B IPO4 CABIN1 ASF1A CDAN1 HIRA | DNA conformation change |
| GO:0034728 | 8.27715903905e-05 | 0.461538461538 | UBN1 CABIN1 ASF1B ASF1A IPO4 HIRA | nucleosome organization |
| REAC:R-HSA-2559586 | 0.000120923462767 | 0.307692307692 | ASF1A UBN1 HIRA CABIN1 | DNA Damage/Telomere Stress Induced Senescence |
| GO:0065004 | 0.000307352591057 | 0.461538461538 | UBN1 CABIN1 ASF1B ASF1A IPO4 HIRA | protein-DNA complex assembly |
| CORUM:2236 | 0.000603007115095 | 0.153846153846 | ASF1A ASF1B | ASF1-histone containing complex |
| GO:0071824 | 0.00116147766683 | 0.461538461538 | UBN1 CABIN1 ASF1B ASF1A IPO4 HIRA | protein-DNA complex subunit organization |
| REAC:R-HSA-2559583 | 0.00384740173459 | 0.307692307692 | ASF1A UBN1 HIRA CABIN1 | Cellular Senescence |
| GO:0006325 | 0.00938163181323 | 0.538461538462 | UBN1 ASF1B IPO4 CABIN1 ASF1A CDAN1 HIRA | chromatin organization |
| HP:0012132 | 0.0153389514134 | 0.153846153846 | C15orf41 CDAN1 | Erythroid hyperplasia |
| GO:0031251 | 0.0351642260875 | 0.153846153846 | PAN3 PAN2 | PAN complex |
| HP:0011273 | 0.0426248406715 | 0.153846153846 | C15orf41 CDAN1 | Anisocytosis |
| HP:0012131 | 0.049704495568 | 0.153846153846 | C15orf41 CDAN1 | Abnormal number of erythroid precursors |
| REAC:R-HSA-429947 | 0.0499064431929 | 0.153846153846 | PAN3 PAN2 | Deadenylation of mRNA |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ASF1A | CDAN1 | 1.0 | 0.949 | hein_WMM bioplex (ASF1A) bioplex_WMM hein (ASF1A) |
| ASF1A | C15orf41 | 0.999 | 0.945 | hein_WMM bioplex (ASF1A) bioplex_WMM hein (ASF1A) |
| ASF1A | UBN1 | 0.973 | 0.886 | hein_WMM bioplex (ASF1A) bioplex_WMM hein (ASF1A) |
| HIRA | ASF1A | 0.971 | 0.883 | hein_WMM bioplex (ASF1A) bioplex_WMM youn_WMM hein (ASF1A) |
| ASF1A | UBN2 | 0.96 | 0.866 | hein_WMM bioplex (ASF1A) bioplex_WMM youn_WMM hein (ASF1A) |
| ASF1A | CABIN1 | 0.948 | 0.856 | hein_WMM bioplex (ASF1A) bioplex_WMM hein (ASF1A) |
| CDAN1 | ASF1B | 0.941 | 0.854 | hein_WMM bioplex (ASF1B) bioplex_WMM |
| UBN1 | ASF1B | 0.897 | 0.822 | hein_WMM bioplex (ASF1B) bioplex_WMM youn_WMM |
| ASF1B | C15orf41 | 0.809 | 0.769 | hein_WMM bioplex (ASF1B) bioplex_WMM |
| CABIN1 | ASF1B | 0.773 | 0.751 | hein_WMM bioplex (ASF1B) bioplex_WMM |
| ASF1B | UBN2 | 0.738 | 0.738 | hein_WMM bioplex (ASF1B) bioplex_WMM youn_WMM |
| ASF1A | IPO4 | 0.677 | 0.706 | hein_WMM bioplex (ASF1A) bioplex_WMM youn_WMM hein (ASF1A) |
| ASF1A | PAN3 | 0.5 | 0.621 | bioplex (ASF1A) bioplex_WMM |
| HIRA | ASF1B | 0.457 | 0.596 | hein_WMM bioplex (ASF1B) bioplex_WMM youn_WMM |
| ASF1A | PAN2 | 0.344 | 0.533 | bioplex (ASF1A) bioplex_WMM |
| ASF1B | PAN3 | 0.148 | 0.41 | bioplex (ASF1B) bioplex_WMM |
| ASF1B | TONSL | 0.13 | 0.4 | bioplex (ASF1B) bioplex_WMM |
| ASF1B | PAN2 | 0.105 | 0.369 | bioplex (ASF1B) bioplex_WMM |
| IPO4 | ASF1B | 0.066 | 0.349 | hein_WMM bioplex (ASF1B) bioplex_WMM youn_WMM |
| ASF1A | TONSL | 0.054 | 0.299 | bioplex (ASF1A) bioplex_WMM |
| CDX1 | CABIN1 | 0.026 | 0.217 | bioplex (CDX1) bioplex_WMM |
| ASF1A | H3C1 | 0.025 | 0.211 | bioplex (ASF1A) bioplex_WMM |
| HIRA | CABIN1 | 0.019 | 0.186 | hein_WMM bioplex_WMM WMM_only |
| ASF1A | ASF1B | 0.015 | 0.151 | hein_WMM bioplex (ASF1A,ASF1B) bioplex_WMM youn_WMM hein (ASF1A) |
| HIRA | UBN2 | 0.015 | 0.143 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| HIRA | CDX1 | 0.014 | 0.137 | bioplex (CDX1) bioplex_WMM |
| CABIN1 | UBN2 | 0.014 | 0.137 | hein_WMM bioplex_WMM WMM_only |
| PAN3 | PAN2 | 0.013 | 0.151 | bioplex_WMM boldt youn_WMM boldt_WMM |
| CDAN1 | C15orf41 | 0.013 | 0.154 | hein_WMM bioplex_WMM WMM_only |
| UBN1 | UBN2 | 0.013 | 0.151 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CDAN1 | UBN1 | 0.012 | 0.149 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| UBN1 | C15orf41 | 0.012 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| CDAN1 | CABIN1 | 0.011 | 0.144 | hein_WMM bioplex_WMM WMM_only |
| CABIN1 | C15orf41 | 0.011 | 0.143 | hein_WMM bioplex_WMM WMM_only |
| HIRA | CDAN1 | 0.011 | 0.14 | hein_WMM bioplex_WMM WMM_only |
| CDAN1 | UBN2 | 0.011 | 0.137 | hein_WMM bioplex_WMM WMM_only |
| HIRA | C15orf41 | 0.011 | 0.137 | hein_WMM bioplex_WMM WMM_only |
| C15orf41 | UBN2 | 0.011 | 0.134 | hein_WMM bioplex_WMM WMM_only |
| CABIN1 | UBN1 | 0.011 | 0.142 | hein_WMM bioplex_WMM WMM_only |
| CDAN1 | PAN3 | 0.011 | 0.143 | bioplex_WMM WMM_only |
| CDAN1 | PAN2 | 0.011 | 0.143 | bioplex_WMM WMM_only |
| HIRA | UBN1 | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| UBN1 | PAN2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| UBN1 | PAN3 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| PAN3 | C15orf41 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| C15orf41 | PAN2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| CDX1 | UBN2 | 0.01 | 0.131 | bioplex (CDX1) bioplex_WMM |
| H3C1 | TONSL | 0.01 | 0.129 | bioplex_WMM WMM_only |
| ASF1B | H3C1 | 0.01 | 0.119 | bioplex (ASF1B) bioplex_WMM |
| HIRA | PAN2 | 0.01 | 0.103 | bioplex_WMM WMM_only |
| HIRA | PAN3 | 0.01 | 0.103 | bioplex_WMM WMM_only |
| PAN3 | UBN2 | 0.01 | 0.104 | bioplex_WMM youn_WMM WMM_only |
| PAN2 | UBN2 | 0.01 | 0.104 | bioplex_WMM youn_WMM WMM_only |
| CABIN1 | PAN2 | 0.009 | 0.113 | bioplex_WMM WMM_only |
| CABIN1 | PAN3 | 0.009 | 0.113 | bioplex_WMM WMM_only |
| CDAN1 | TONSL | 0.009 | 0.107 | bioplex_WMM WMM_only |
| PAN3 | TONSL | 0.009 | 0.108 | bioplex_WMM WMM_only |
| TONSL | PAN2 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| UBN1 | TONSL | 0.009 | 0.108 | bioplex_WMM WMM_only |
| TONSL | C15orf41 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| CDAN1 | IPO4 | 0.009 | 0.108 | hein_WMM bioplex_WMM WMM_only |
| IPO4 | C15orf41 | 0.009 | 0.11 | hein_WMM bioplex_WMM WMM_only |
| IPO4 | TONSL | 0.009 | 0.106 | bioplex_WMM WMM_only |
| CDAN1 | H3C1 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| H3C1 | PAN2 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| UBN1 | H3C1 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| H3C1 | PAN3 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| H3C1 | C15orf41 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| IPO4 | PAN2 | 0.009 | 0.098 | bioplex_WMM youn_WMM WMM_only |
| IPO4 | PAN3 | 0.009 | 0.098 | bioplex_WMM youn_WMM WMM_only |
| IPO4 | UBN1 | 0.008 | 0.095 | hein_WMM bioplex_WMM WMM_only |
| HIRA | TONSL | 0.008 | 0.082 | bioplex_WMM WMM_only |
| TONSL | UBN2 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| CABIN1 | TONSL | 0.008 | 0.078 | bioplex_WMM WMM_only |
| IPO4 | CABIN1 | 0.008 | 0.061 | hein_WMM bioplex_WMM WMM_only |
| IPO4 | H3C1 | 0.008 | 0.061 | bioplex_WMM WMM_only |
| IPO4 | UBN2 | 0.008 | 0.042 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| HIRA | IPO4 | 0.008 | 0.044 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| HIRA | H3C1 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| H3C1 | UBN2 | 0.008 | 0.039 | bioplex_WMM WMM_only |
| CABIN1 | H3C1 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| CDX1 | H3C1 | 0.006 | 0.009 | bioplex (CDX1) bioplex_WMM |
| ASF1A | CDX1 | 0.006 | 0.007 | bioplex (CDX1) bioplex_WMM |
| CDX1 | ASF1B | 0.005 | 0.012 | bioplex (CDX1) |
Images
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Complex HuMAP2_01017 has an average edge precision of 0.247 which is ranked 5423 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| H3C1 | HuMAP2_01017 HuMAP2_04079 |
| HIRA | HuMAP2_01017 |
| ASF1A | HuMAP2_01017 HuMAP2_03138 |
| IPO4 | HuMAP2_01017 HuMAP2_06544 |
| TONSL | HuMAP2_01017 HuMAP2_06636 |
| PAN2 | HuMAP2_01017 |
| CDAN1 | HuMAP2_01017 HuMAP2_03138 |
| CABIN1 | HuMAP2_01017 HuMAP2_02693 HuMAP2_03138 HuMAP2_05099 |
| UBN2 | HuMAP2_01017 HuMAP2_03138 |
| CDX1 | HuMAP2_01017 HuMAP2_02693 HuMAP2_05099 |
| UBN1 | HuMAP2_01017 HuMAP2_03138 |
| ASF1B | HuMAP2_01017 HuMAP2_03138 |
| PAN3 | HuMAP2_01017 |
| C15orf41 | HuMAP2_01017 HuMAP2_03138 |