hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01021
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) | UniProt NCBI |
| CPSF6 | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | UniProt NCBI |
| CPSF7 | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1990120 | 9.08185760231e-08 | 1.0 | NUDT21 CPSF7 CPSF6 | messenger ribonucleoprotein complex assembly |
| CORUM:1141 | 1.02537101962e-07 | 1.0 | NUDT21 CPSF7 CPSF6 | CF IIAm complex (Cleavage factor IIAm complex) |
| GO:0110104 | 3.63274304092e-07 | 1.0 | NUDT21 CPSF7 CPSF6 | mRNA alternative polyadenylation |
| KEGG:03015 | 3.30002227102e-06 | 1.0 | NUDT21 CPSF7 CPSF6 | mRNA surveillance pathway |
| GO:0098789 | 1.99800867251e-05 | 1.0 | NUDT21 CPSF7 CPSF6 | pre-mRNA cleavage required for polyadenylation |
| CORUM:1769 | 2.01342304124e-05 | 0.666666666667 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A complex |
| GO:0098787 | 2.59741127426e-05 | 1.0 | NUDT21 CPSF7 CPSF6 | mRNA cleavage involved in mRNA processing |
| CORUM:1767 | 3.35555483123e-05 | 0.666666666667 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex |
| CORUM:1768 | 5.03310689057e-05 | 0.666666666667 | NUDT21 CPSF6 | CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex |
| GO:0005847 | 5.08584025729e-05 | 1.0 | NUDT21 CPSF7 CPSF6 | mRNA cleavage and polyadenylation specificity factor complex |
| GO:1900363 | 5.08584025729e-05 | 1.0 | NUDT21 CPSF7 CPSF6 | regulation of mRNA polyadenylation |
| GO:0006379 | 7.41079580349e-05 | 1.0 | NUDT21 CPSF7 CPSF6 | mRNA cleavage |
| GO:0005849 | 8.80032001664e-05 | 1.0 | NUDT21 CPSF7 CPSF6 | mRNA cleavage factor complex |
| GO:0031440 | 0.00023612829766 | 1.0 | NUDT21 CPSF7 CPSF6 | regulation of mRNA 3'-end processing |
| GO:0006378 | 0.000897287531108 | 1.0 | NUDT21 CPSF7 CPSF6 | mRNA polyadenylation |
| GO:0043631 | 0.00104259725275 | 1.0 | NUDT21 CPSF7 CPSF6 | RNA polyadenylation |
| REAC:R-HSA-77595 | 0.00114404160216 | 0.666666666667 | NUDT21 CPSF7 | Processing of Intronless Pre-mRNAs |
| GO:0051290 | 0.00128871559377 | 1.0 | NUDT21 CPSF7 CPSF6 | protein heterotetramerization |
| GO:0090501 | 0.0015707980909 | 1.0 | NUDT21 CPSF7 CPSF6 | RNA phosphodiester bond hydrolysis |
| REAC:R-HSA-75067 | 0.00252791438215 | 0.666666666667 | NUDT21 CPSF7 | Processing of Capped Intronless Pre-mRNA |
| GO:0051291 | 0.00435066388439 | 1.0 | NUDT21 CPSF7 CPSF6 | protein heterooligomerization |
| REAC:R-HSA-72187 | 0.00955880978777 | 0.666666666667 | NUDT21 CPSF7 | mRNA 3'-end processing |
| GO:0031124 | 0.0117851633362 | 1.0 | NUDT21 CPSF7 CPSF6 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 0.0130404028432 | 0.666666666667 | NUDT21 CPSF7 | RNA Polymerase II Transcription Termination |
| GO:0042382 | 0.0135228859698 | 0.666666666667 | NUDT21 CPSF6 | paraspeckles |
| HPA:047020_13 | 0.0149221793772 | 0.666666666667 | CPSF6 CPSF7 | soft tissue 1; chondrocytes[Supported,High] |
| HPA:008010_13 | 0.0250437145165 | 0.666666666667 | CPSF6 CPSF7 | cerebral cortex; endothelial cells[Supported,High] |
| GO:0050684 | 0.0261539335231 | 1.0 | NUDT21 CPSF7 CPSF6 | regulation of mRNA processing |
| HPA:024020_03 | 0.026478163727 | 1.0 | NUDT21 CPSF7 CPSF6 | kidney; cells in tubules[Uncertain,High] |
| GO:0090305 | 0.0310032822085 | 1.0 | NUDT21 CPSF7 CPSF6 | nucleic acid phosphodiester bond hydrolysis |
| GO:0051262 | 0.0310032822085 | 1.0 | NUDT21 CPSF7 CPSF6 | protein tetramerization |
| HPA:048010_13 | 0.0310755999363 | 0.666666666667 | CPSF6 CPSF7 | soft tissue 2; adipocytes[Supported,High] |
| HPA:051010_03 | 0.0321008510664 | 1.0 | NUDT21 CPSF7 CPSF6 | stomach 1; glandular cells[Uncertain,High] |
| CORUM:351 | 0.0324522040239 | 0.666666666667 | NUDT21 CPSF6 | Spliceosome |
| HPA:004010_13 | 0.0329176593671 | 0.666666666667 | CPSF6 CPSF7 | breast; adipocytes[Supported,High] |
| GO:0031123 | 0.0356085105614 | 1.0 | NUDT21 CPSF7 CPSF6 | RNA 3'-end processing |
| HPA:050020_02 | 0.0385825976264 | 1.0 | NUDT21 CPSF7 CPSF6 | spleen; cells in white pulp[Uncertain,Medium] |
| HPA:047020_03 | 0.044531062015 | 0.666666666667 | CPSF6 CPSF7 | soft tissue 1; chondrocytes[Uncertain,High] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUDT21 | CPSF6 | 1.0 | 0.949 | hein_WMM bioplex (CPSF6) bioplex_WMM Guru boldt youn_WMM hein (NUDT21) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| CPSF6 | CPSF7 | 0.993 | 0.918 | hein_WMM bioplex (CPSF6) bioplex_WMM youn_WMM hein (CPSF7) gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT21 | CPSF7 | 0.553 | 0.645 | hein_WMM bioplex_WMM youn_WMM hein (CPSF7,NUDT21) gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_01021 has an average edge precision of 0.837 which is ranked 822 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NUDT21 | HuMAP2_00504 HuMAP2_01021 HuMAP2_02463 HuMAP2_05632 |
| CPSF6 | HuMAP2_01021 HuMAP2_05632 |
| CPSF7 | HuMAP2_01021 HuMAP2_03566 HuMAP2_05632 |