hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01027
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDC27 | Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) | UniProt NCBI |
| ANAPC4 | Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4) | UniProt NCBI |
| CDC23 | Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) | UniProt NCBI |
| ANAPC1 | Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) | UniProt NCBI |
| CDC16 | Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:93 | 6.82660660174e-16 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Anaphase-promoting complex |
| CORUM:96 | 1.53598648539e-15 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Anaphase-promoting complex |
| REAC:R-HSA-176412 | 2.10145025259e-13 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Phosphorylation of the APC/C |
| REAC:R-HSA-176407 | 2.10145025259e-13 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| REAC:R-HSA-141430 | 2.85196819994e-13 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Inactivation of APC/C via direct inhibition of the APC/C complex |
| REAC:R-HSA-141405 | 2.85196819994e-13 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| REAC:R-HSA-174048 | 6.45886915869e-13 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | APC/C:Cdc20 mediated degradation of Cyclin B |
| REAC:R-HSA-179409 | 1.04248414491e-12 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | APC-Cdc20 mediated degradation of Nek2A |
| GO:0005680 | 1.27007650504e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | anaphase-promoting complex |
| REAC:R-HSA-174084 | 1.58712520861e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Autodegradation of Cdh1 by Cdh1:APC/C |
| KEGG:04914 | 1.99895493029e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Progesterone-mediated oocyte maturation |
| REAC:R-HSA-174154 | 2.19193622817e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | APC/C:Cdc20 mediated degradation of Securin |
| REAC:R-HSA-174178 | 3.19335796647e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| REAC:R-HSA-174184 | 3.19335796647e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| REAC:R-HSA-69017 | 3.19335796647e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | CDK-mediated phosphorylation and removal of Cdc6 |
| REAC:R-HSA-179419 | 3.43166826248e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| REAC:R-HSA-176409 | 3.95095310186e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-176814 | 4.2331640377e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-176408 | 5.52771552165e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Regulation of APC/C activators between G1/S and early anaphase |
| GO:0070979 | 6.6133434115e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | protein K11-linked ubiquitination |
| REAC:R-HSA-174143 | 8.04513961076e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | APC/C-mediated degradation of cell cycle proteins |
| REAC:R-HSA-453276 | 8.04513961076e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Regulation of mitotic cell cycle |
| KEGG:04114 | 8.29402009689e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Oocyte meiosis |
| WP:WP179 | 9.73258611228e-10 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Cell Cycle |
| REAC:R-HSA-69052 | 1.01804674096e-09 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Switching of origins to a post-replicative state |
| KEGG:04110 | 1.48685851061e-09 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Cell cycle |
| KEGG:04120 | 2.23322702966e-09 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-2559582 | 2.48556033459e-09 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-69618 | 2.60740152746e-09 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-69239 | 4.29128105718e-09 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Synthesis of DNA |
| REAC:R-HSA-69306 | 5.98998307108e-09 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | DNA Replication |
| GO:0000152 | 6.96861094163e-09 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | nuclear ubiquitin ligase complex |
| KEGG:05166 | 1.83286941887e-08 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-69242 | 1.94925460906e-08 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | S Phase |
| REAC:R-HSA-2467813 | 3.96994964557e-08 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Separation of Sister Chromatids |
| REAC:R-HSA-2559583 | 4.54946534313e-08 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Cellular Senescence |
| REAC:R-HSA-68882 | 4.9284078172e-08 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 5.06018342728e-08 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Mitotic Metaphase and Anaphase |
| GO:0031145 | 1.96934078318e-07 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | anaphase-promoting complex-dependent catabolic process |
| REAC:R-HSA-69620 | 3.84287249539e-07 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Cell Cycle Checkpoints |
| REAC:R-HSA-983168 | 4.19201259121e-07 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-983169 | 1.02822402968e-06 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Class I MHC mediated antigen processing & presentation |
| REAC:R-HSA-68886 | 1.51565133528e-06 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | M Phase |
| REAC:R-HSA-2262752 | 2.22700035802e-06 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Cellular responses to stress |
| GO:0031461 | 4.52759192471e-06 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | cullin-RING ubiquitin ligase complex |
| REAC:R-HSA-8953897 | 5.54154114711e-06 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Cellular responses to external stimuli |
| REAC:R-HSA-69278 | 7.33273154143e-06 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 1.81282652788e-05 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Cell Cycle |
| CORUM:5361 | 2.0123342217e-05 | 0.4 | CDC27 CDC16 | Cell division cycle complex (CDC27, CDC16, ANAPC7) |
| GO:0007091 | 2.17063078318e-05 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | metaphase/anaphase transition of mitotic cell cycle |
| REAC:R-HSA-1280218 | 2.29940671928e-05 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Adaptive Immune System |
| GO:0044784 | 2.36783333556e-05 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | metaphase/anaphase transition of cell cycle |
| GO:0010965 | 2.57816855599e-05 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | regulation of mitotic sister chromatid separation |
| GO:0051306 | 3.04052805885e-05 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | mitotic sister chromatid separation |
| GO:1905818 | 3.56241182538e-05 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | regulation of chromosome separation |
| GO:0033047 | 5.93016865488e-05 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | regulation of mitotic sister chromatid segregation |
| GO:0000151 | 7.35990796011e-05 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | ubiquitin ligase complex |
| GO:0000209 | 9.61471171118e-05 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | protein polyubiquitination |
| GO:0033045 | 0.000111444253056 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | regulation of sister chromatid segregation |
| GO:0051304 | 0.000139822988547 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | chromosome separation |
| GO:0051983 | 0.000310236355112 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | regulation of chromosome segregation |
| GO:1901990 | 0.000338506670814 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | regulation of mitotic cell cycle phase transition |
| GO:0043161 | 0.000418527715825 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO:1901987 | 0.0004797982371 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | regulation of cell cycle phase transition |
| GO:0010498 | 0.000810360313539 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | proteasomal protein catabolic process |
| GO:0007088 | 0.00146369592834 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | regulation of mitotic nuclear division |
| GO:0044772 | 0.00151627970582 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | mitotic cell cycle phase transition |
| GO:0006511 | 0.00177594994385 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | ubiquitin-dependent protein catabolic process |
| GO:0000070 | 0.00180327283687 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | mitotic sister chromatid segregation |
| GO:0019941 | 0.00185087474313 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | modification-dependent protein catabolic process |
| GO:0051783 | 0.00185620980997 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | regulation of nuclear division |
| GO:0043632 | 0.00207003662248 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | modification-dependent macromolecule catabolic process |
| GO:0044770 | 0.00209094608332 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | cell cycle phase transition |
| GO:0007346 | 0.00244913233484 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | regulation of mitotic cell cycle |
| REAC:R-HSA-168256 | 0.00339317023665 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | Immune System |
| GO:0000819 | 0.00360020272665 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | sister chromatid segregation |
| GO:0016567 | 0.00400049209339 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | protein ubiquitination |
| GO:0051603 | 0.0041074517567 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | proteolysis involved in cellular protein catabolic process |
| GO:0010564 | 0.00544233743161 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | regulation of cell cycle process |
| GO:0044257 | 0.00640677563005 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | cellular protein catabolic process |
| GO:0032446 | 0.00732992354676 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | protein modification by small protein conjugation |
| GO:0098813 | 0.00896454920435 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | nuclear chromosome segregation |
| GO:1990234 | 0.0112296002627 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | transferase complex |
| GO:1903047 | 0.0124910964308 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | mitotic cell cycle process |
| GO:0140014 | 0.0129837343661 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | mitotic nuclear division |
| GO:0030163 | 0.0138634979379 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | protein catabolic process |
| GO:0007059 | 0.0197450207423 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | chromosome segregation |
| GO:0070647 | 0.023802724014 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | protein modification by small protein conjugation or removal |
| GO:0000278 | 0.02689008569 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | mitotic cell cycle |
| GO:0033044 | 0.0284335460005 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | regulation of chromosome organization |
| GO:0051726 | 0.0398642747089 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | regulation of cell cycle |
| GO:0000280 | 0.0441192366731 | 0.8 | CDC27 ANAPC1 ANAPC4 CDC23 | nuclear division |
| CORUM:0000000 | 0.0474603483533 | 1.0 | CDC27 ANAPC1 CDC16 ANAPC4 CDC23 | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDC16 | ANAPC1 | 1.0 | 0.949 | hein_WMM bioplex (CDC16) bioplex_WMM youn_WMM hein (CDC16) Malo gupta_WMM fraction boldt_WMM |
| CDC27 | ANAPC1 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction boldt_WMM |
| CDC27 | CDC23 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt (CDC23) youn_WMM hein (CDC23) Malo gupta_WMM fraction boldt_WMM |
| ANAPC4 | CDC16 | 1.0 | 0.949 | hein_WMM bioplex (CDC16) bioplex_WMM youn_WMM hein (CDC16) Malo gupta_WMM fraction boldt_WMM |
| CDC27 | CDC16 | 1.0 | 0.949 | hein_WMM bioplex (CDC16) bioplex_WMM boldt youn_WMM hein (CDC16) Malo gupta_WMM fraction boldt_WMM |
| CDC16 | CDC23 | 1.0 | 0.949 | hein_WMM bioplex (CDC16) bioplex_WMM boldt (CDC23) youn_WMM hein (CDC16,CDC23) Malo gupta_WMM fraction boldt_WMM |
| ANAPC4 | ANAPC1 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction boldt_WMM |
| CDC27 | ANAPC4 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction boldt_WMM |
| ANAPC4 | CDC23 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (CDC23) Malo gupta_WMM fraction boldt_WMM |
| ANAPC1 | CDC23 | 0.764 | 0.748 | hein_WMM bioplex_WMM youn_WMM hein (CDC23) gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_01027 has an average edge precision of 0.929 which is ranked 437 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDC27 | HuMAP2_00729 HuMAP2_01027 HuMAP2_01190 HuMAP2_03601 |
| ANAPC4 | HuMAP2_00729 HuMAP2_01027 HuMAP2_01190 HuMAP2_03601 |
| CDC23 | HuMAP2_00729 HuMAP2_01027 HuMAP2_01190 HuMAP2_03601 |
| ANAPC1 | HuMAP2_00729 HuMAP2_01027 HuMAP2_01190 HuMAP2_03601 |
| CDC16 | HuMAP2_00729 HuMAP2_01027 HuMAP2_01190 HuMAP2_03601 HuMAP2_04342 |