hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01034
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PMM1 | Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22) | UniProt NCBI |
| PMM2 | Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446205 | 1.67592346237e-05 | 1.0 | PMM2 PMM1 | Synthesis of GDP-mannose |
| KEGG:00051 | 7.70339033036e-05 | 1.0 | PMM2 PMM1 | Fructose and mannose metabolism |
| KEGG:00520 | 0.00015100395818 | 1.0 | PMM2 PMM1 | Amino sugar and nucleotide sugar metabolism |
| GO:0004615 | 0.000450823411379 | 1.0 | PMM2 PMM1 | phosphomannomutase activity |
| GO:0009298 | 0.00270494046827 | 1.0 | PMM2 PMM1 | GDP-mannose biosynthetic process |
| REAC:R-HSA-446219 | 0.00277030148331 | 1.0 | PMM2 PMM1 | Synthesis of substrates in N-glycan biosythesis |
| REAC:R-HSA-446193 | 0.00440432685912 | 1.0 | PMM2 PMM1 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| GO:0019673 | 0.00676235117068 | 1.0 | PMM2 PMM1 | GDP-mannose metabolic process |
| GO:0006013 | 0.00946729163895 | 1.0 | PMM2 PMM1 | mannose metabolic process |
| GO:0016868 | 0.020287053512 | 1.0 | PMM2 PMM1 | intramolecular transferase activity, phosphotransferases |
| REAC:R-HSA-4043911 | 0.0249595281251 | 0.5 | PMM2 | Defective PMM2 causes PMM2-CDG (CDG-1a) |
| HP:0012509 | 0.0497341708567 | 0.5 | PMM2 | Reduced thyroxin-binding globulin |
| HP:0012882 | 0.0497341708567 | 0.5 | PMM2 | Hyperplastic labia majora |
| HP:0040238 | 0.0497341708567 | 0.5 | PMM2 | Impaired neutrophil chemotaxis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PMM2 | PMM1 | 0.995 | 0.923 | bioplex (PMM1) bioplex_WMM |
Images
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Complex HuMAP2_01034 has an average edge precision of 0.923 which is ranked 461 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PMM1 | HuMAP2_00312 HuMAP2_00655 HuMAP2_01034 HuMAP2_02764 HuMAP2_04511 HuMAP2_07014 |
| PMM2 | HuMAP2_00312 HuMAP2_00655 HuMAP2_01034 HuMAP2_04511 |