hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01040
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NPRL3 | GATOR complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA) | UniProt NCBI |
| BMT2 | S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) | UniProt NCBI |
| SZT2 | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | UniProt NCBI |
| DEPDC5 | GATOR complex protein DEPDC5 (DEP domain-containing protein 5) | UniProt NCBI |
| NPRL2 | GATOR complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) | UniProt NCBI |
| ZBTB5 | Zinc finger and BTB domain-containing protein 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1990130 | 2.94892899195e-13 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | GATOR1 complex |
| GO:0035859 | 3.03945621632e-10 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | Seh1-associated complex |
| CORUM:6215 | 2.25356268047e-09 | 0.5 | DEPDC5 NPRL3 NPRL2 | GATOR1 complex |
| GO:0032007 | 1.36545195896e-08 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | negative regulation of TOR signaling |
| GO:0034198 | 1.8497597492e-08 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | cellular response to amino acid starvation |
| GO:1990928 | 2.13866479475e-08 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | response to amino acid starvation |
| CORUM:6753 | 1.26104188141e-07 | 0.5 | NPRL2 NPRL3 SZT2 | SOG complex |
| CORUM:6217 | 1.26104188141e-07 | 0.5 | DEPDC5 NPRL3 NPRL2 | GATOR complex |
| GO:0032006 | 1.17664441353e-06 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | regulation of TOR signaling |
| HP:0032046 | 1.69374357824e-06 | 0.5 | DEPDC5 NPRL3 NPRL2 | Focal cortical dysplasia |
| GO:0031929 | 2.54188840198e-06 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | TOR signaling |
| GO:0009267 | 3.68082360643e-06 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | cellular response to starvation |
| GO:0042594 | 6.55437615032e-06 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | response to starvation |
| GO:0031669 | 1.62912393021e-05 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | cellular response to nutrient levels |
| GO:0038202 | 2.40824494048e-05 | 0.666666666667 | BMT2 SZT2 NPRL3 DEPDC5 | TORC1 signaling |
| GO:0031668 | 2.42948199319e-05 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | cellular response to extracellular stimulus |
| GO:0071496 | 6.84894530877e-05 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | cellular response to external stimulus |
| HP:0032052 | 7.51372352298e-05 | 0.333333333333 | DEPDC5 NPRL3 | Focal cortical dysplasia type IIa |
| GO:0031667 | 9.02374671517e-05 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | response to nutrient levels |
| GO:0009991 | 0.000129609451849 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | response to extracellular stimulus |
| GO:1904262 | 0.000660060925697 | 0.5 | BMT2 SZT2 DEPDC5 | negative regulation of TORC1 signaling |
| HP:0032051 | 0.000750968775169 | 0.333333333333 | DEPDC5 NPRL3 | Focal cortical dysplasia type II |
| KEGG:04150 | 0.000802296549804 | 0.5 | DEPDC5 NPRL3 NPRL2 | mTOR signaling pathway |
| HP:0002539 | 0.00109361304916 | 0.5 | DEPDC5 NPRL3 NPRL2 | Cortical dysplasia |
| GO:1902532 | 0.00210940994947 | 0.833333333333 | BMT2 NPRL2 SZT2 NPRL3 DEPDC5 | negative regulation of intracellular signal transduction |
| HP:0003829 | 0.00614519903403 | 0.5 | DEPDC5 NPRL3 NPRL2 | Incomplete penetrance |
| GO:1903432 | 0.00896978520187 | 0.5 | BMT2 SZT2 DEPDC5 | regulation of TORC1 signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DEPDC5 | NPRL2 | 0.773 | 0.752 | bioplex (DEPDC5,NPRL2) bioplex_WMM |
| DEPDC5 | BMT2 | 0.533 | 0.638 | bioplex (BMT2) bioplex_WMM |
| BMT2 | SZT2 | 0.353 | 0.539 | bioplex (BMT2) bioplex_WMM |
| NPRL2 | NPRL3 | 0.057 | 0.323 | bioplex (NPRL2,NPRL3) bioplex_WMM |
| DEPDC5 | SZT2 | 0.05 | 0.298 | hein_WMM bioplex (DEPDC5) bioplex_WMM |
| NPRL2 | ZBTB5 | 0.045 | 0.282 | bioplex (NPRL2) bioplex_WMM |
| BMT2 | NPRL3 | 0.027 | 0.225 | bioplex (BMT2) bioplex_WMM |
| BMT2 | NPRL2 | 0.02 | 0.187 | bioplex (BMT2) bioplex_WMM |
| DEPDC5 | NPRL3 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| NPRL2 | SZT2 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| DEPDC5 | ZBTB5 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| NPRL3 | SZT2 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| ZBTB5 | NPRL3 | 0.007 | 0.01 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_01040 has an average edge precision of 0.268 which is ranked 5061 out of all 6965 complexes.
Related Complexes