hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01043
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BCAR3 | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | UniProt NCBI |
| BCAR1 | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | UniProt NCBI |
| NEDD9 | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | UniProt NCBI |
| APOC2 | Apolipoprotein C-II (Apo-CII) (ApoC-II) (Apolipoprotein C2) [Cleaved into: Proapolipoprotein C-II (ProapoC-II)] | UniProt NCBI |
| GAST | Gastrin [Cleaved into: Gastrin-71 (Gastrin component I); Gastrin-52 (G52); Big gastrin (Gastrin component II) (Gastrin-34) (G34); Gastrin (Gastrin component III) (Gastrin-17) (G17); Gastrin-14 (G14); Gastrin-6 (G6)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP366 | 0.0250517914711 | 0.4 | NEDD9 BCAR1 | TGF-beta Signaling Pathway |
| WP:WP2597 | 0.0372906105173 | 0.2 | GAST | Secretion of Hydrochloric Acid in Parietal Cells |
| WP:WP2596 | 0.0372906105173 | 0.2 | GAST | Gastric acid production |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BCAR3 | BCAR1 | 1.0 | 0.949 | bioplex (BCAR3) bioplex_WMM youn_WMM |
| BCAR3 | NEDD9 | 0.442 | 0.586 | bioplex (BCAR3) bioplex_WMM youn_WMM |
| APOC2 | GAST | 0.075 | 0.357 | bioplex (GAST) bioplex_WMM |
| BCAR3 | GAST | 0.074 | 0.356 | bioplex (BCAR3) bioplex_WMM |
| NEDD9 | BCAR1 | 0.009 | 0.097 | bioplex_WMM youn_WMM WMM_only |
| BCAR1 | GAST | 0.008 | 0.085 | bioplex_WMM WMM_only |
| NEDD9 | GAST | 0.008 | 0.06 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01043 has an average edge precision of 0.356 which is ranked 3833 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BCAR3 | HuMAP2_01043 HuMAP2_01259 HuMAP2_05998 HuMAP2_06085 |
| BCAR1 | HuMAP2_01043 HuMAP2_01259 HuMAP2_05998 HuMAP2_06085 |
| NEDD9 | HuMAP2_01043 HuMAP2_02488 HuMAP2_05998 HuMAP2_06085 |
| APOC2 | HuMAP2_01043 HuMAP2_01591 HuMAP2_02581 HuMAP2_03546 |
| GAST | HuMAP2_01043 HuMAP2_01591 HuMAP2_02581 HuMAP2_03546 |