hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01048
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KRT6A | Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5) | UniProt NCBI |
| KRT17 | Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) | UniProt NCBI |
| KRT5 | Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0025125 | 5.75184314813e-07 | 1.0 | KRT5 KRT17 KRT6A | White lesion of the oral mucosa |
| HP:0002745 | 5.75184314813e-07 | 1.0 | KRT5 KRT17 KRT6A | Oral leukoplakia |
| HP:0001805 | 5.75184314813e-07 | 1.0 | KRT5 KRT17 KRT6A | Onychogryposis |
| HP:0010765 | 3.23860229269e-06 | 1.0 | KRT5 KRT17 KRT6A | Palmar hyperkeratosis |
| HP:0007556 | 5.42477755735e-06 | 1.0 | KRT5 KRT17 KRT6A | Plantar hyperkeratosis |
| HP:0100872 | 3.11003168115e-05 | 1.0 | KRT5 KRT17 KRT6A | Abnormality of the plantar skin of foot |
| HP:0008066 | 3.39263772065e-05 | 1.0 | KRT5 KRT17 KRT6A | Abnormal blistering of the skin |
| REAC:R-HSA-6809371 | 6.83818917763e-05 | 1.0 | KRT5 KRT17 KRT6A | Formation of the cornified envelope |
| HP:0008404 | 8.48114911254e-05 | 1.0 | KRT5 KRT17 KRT6A | Nail dystrophy |
| HP:0000975 | 0.00012118403403 | 1.0 | KRT5 KRT17 KRT6A | Hyperhidrosis |
| REAC:R-HSA-6805567 | 0.000153481595091 | 1.0 | KRT5 KRT17 KRT6A | Keratinization |
| HP:0000982 | 0.000222392730018 | 1.0 | KRT5 KRT17 KRT6A | Palmoplantar keratoderma |
| HP:0200040 | 0.000318128568027 | 0.666666666667 | KRT17 KRT6A | Epidermoid cyst |
| HP:0007550 | 0.000333876983978 | 1.0 | KRT5 KRT17 KRT6A | Hypohidrosis or hyperhidrosis |
| HP:0025276 | 0.000375567459056 | 1.0 | KRT5 KRT17 KRT6A | Abnormality of skin adnexa physiology |
| HP:0040211 | 0.000756344224146 | 1.0 | KRT5 KRT17 KRT6A | Abnormality of the skin of the palm |
| HP:0200035 | 0.000803978270478 | 0.666666666667 | KRT17 KRT6A | Skin plaque |
| HP:0025245 | 0.000803978270478 | 0.666666666667 | KRT17 KRT6A | Cutaneous cyst |
| HP:0000962 | 0.000942605406959 | 1.0 | KRT5 KRT17 KRT6A | Hyperkeratosis |
| HP:0100643 | 0.00106009615223 | 0.666666666667 | KRT17 KRT6A | Abnormality of nail color |
| HP:0011830 | 0.00112686264524 | 1.0 | KRT5 KRT17 KRT6A | Abnormal oral mucosa morphology |
| HP:0011061 | 0.00140207320345 | 1.0 | KRT5 KRT17 KRT6A | Abnormality of dental structure |
| HP:0100871 | 0.00192567434784 | 1.0 | KRT5 KRT17 KRT6A | Abnormality of the palm |
| HP:0011356 | 0.00205742657748 | 1.0 | KRT5 KRT17 KRT6A | Regional abnormality of skin |
| HP:0011368 | 0.00321143982185 | 1.0 | KRT5 KRT17 KRT6A | Epidermal thickening |
| HP:0001597 | 0.00349099720641 | 1.0 | KRT5 KRT17 KRT6A | Abnormality of the nail |
| HP:0000972 | 0.00358457001899 | 0.666666666667 | KRT5 KRT17 | Palmoplantar hyperkeratosis |
| HP:0001072 | 0.00435163677096 | 1.0 | KRT5 KRT17 KRT6A | Thickened skin |
| HP:0002093 | 0.00781090802149 | 1.0 | KRT5 KRT17 KRT6A | Respiratory insufficiency |
| GO:0005200 | 0.0106693663112 | 1.0 | KRT5 KRT17 KRT6A | structural constituent of cytoskeleton |
| HP:0001601 | 0.0108053329976 | 0.666666666667 | KRT17 KRT6A | Laryngomalacia |
| GO:0070268 | 0.0117851633362 | 1.0 | KRT5 KRT17 KRT6A | cornification |
| HP:0001798 | 0.0121532611158 | 0.666666666667 | KRT17 KRT6A | Anonychia |
| HP:0001131 | 0.0225234057432 | 0.666666666667 | KRT17 KRT6A | Corneal dystrophy |
| HP:0011355 | 0.0259340813389 | 1.0 | KRT5 KRT17 KRT6A | Localized skin lesion |
| GO:0031424 | 0.0281650200706 | 1.0 | KRT5 KRT17 KRT6A | keratinization |
| HP:0000164 | 0.0293567877248 | 1.0 | KRT5 KRT17 KRT6A | Abnormality of the dentition |
| HP:0025423 | 0.0329433889933 | 0.666666666667 | KRT17 KRT6A | Abnormal larynx morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KRT17 | KRT5 | 0.037 | 0.263 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT17 | KRT6A | 0.022 | 0.206 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT6A | KRT5 | 0.005 | 0.017 | youn_WMM gupta_WMM WMM_only boldt_WMM |
Images
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Complex HuMAP2_01048 has an average edge precision of 0.162 which is ranked 6607 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KRT6A | HuMAP2_00172 HuMAP2_01048 HuMAP2_01970 |
| KRT17 | HuMAP2_00172 HuMAP2_01048 HuMAP2_01970 |
| KRT5 | HuMAP2_00172 HuMAP2_00512 HuMAP2_01048 HuMAP2_01970 HuMAP2_04038 |