hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01050
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CTC1 | CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) | UniProt NCBI |
| TEN1 | CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog) | UniProt NCBI |
| STN1 | CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6075 | 2.25356268047e-10 | 1.0 | STN1 CTC1 TEN1 | CST complex |
| GO:1990879 | 9.08185760231e-08 | 1.0 | STN1 CTC1 TEN1 | CST complex |
| GO:0000782 | 1.99800867251e-05 | 1.0 | STN1 CTC1 TEN1 | telomere cap complex |
| GO:0000783 | 1.99800867251e-05 | 1.0 | STN1 CTC1 TEN1 | nuclear telomere cap complex |
| GO:0032211 | 0.000103533176666 | 1.0 | STN1 CTC1 TEN1 | negative regulation of telomere maintenance via telomerase |
| GO:1904357 | 0.000265644334868 | 1.0 | STN1 CTC1 TEN1 | negative regulation of telomere maintenance via telomere lengthening |
| GO:2000279 | 0.000368723418654 | 1.0 | STN1 CTC1 TEN1 | negative regulation of DNA biosynthetic process |
| GO:0032205 | 0.000594407580071 | 1.0 | STN1 CTC1 TEN1 | negative regulation of telomere maintenance |
| GO:0042162 | 0.000648444632805 | 1.0 | STN1 CTC1 TEN1 | telomeric DNA binding |
| HP:0007763 | 0.00106009615223 | 0.666666666667 | CTC1 STN1 | Retinal telangiectasia |
| GO:0032210 | 0.00189129684568 | 1.0 | STN1 CTC1 TEN1 | regulation of telomere maintenance via telomerase |
| GO:0016233 | 0.00212751596192 | 1.0 | STN1 CTC1 TEN1 | telomere capping |
| GO:1904356 | 0.00295242108794 | 1.0 | STN1 CTC1 TEN1 | regulation of telomere maintenance via telomere lengthening |
| HP:0002216 | 0.00358457001899 | 0.666666666667 | CTC1 STN1 | Premature graying of hair |
| GO:0007004 | 0.00435066388439 | 1.0 | STN1 CTC1 TEN1 | telomere maintenance via telomerase |
| GO:0006278 | 0.00455146375597 | 1.0 | STN1 CTC1 TEN1 | RNA-dependent DNA biosynthetic process |
| GO:0032204 | 0.00638454589443 | 1.0 | STN1 CTC1 TEN1 | regulation of telomere maintenance |
| GO:0010833 | 0.00690911398953 | 1.0 | STN1 CTC1 TEN1 | telomere maintenance via telomere lengthening |
| GO:2000278 | 0.00996606725847 | 1.0 | STN1 CTC1 TEN1 | regulation of DNA biosynthetic process |
| GO:0051053 | 0.0125706532002 | 1.0 | STN1 CTC1 TEN1 | negative regulation of DNA metabolic process |
| GO:0000784 | 0.0242409310378 | 1.0 | STN1 CTC1 TEN1 | nuclear chromosome, telomeric region |
| GO:2001251 | 0.0261539335231 | 1.0 | STN1 CTC1 TEN1 | negative regulation of chromosome organization |
| HP:0009887 | 0.028539256711 | 0.666666666667 | CTC1 STN1 | Abnormality of hair pigmentation |
| GO:0032993 | 0.0380729634404 | 1.0 | STN1 CTC1 TEN1 | protein-DNA complex |
| GO:0000781 | 0.0397775372938 | 1.0 | STN1 CTC1 TEN1 | chromosome, telomeric region |
| GO:0071897 | 0.043337807111 | 1.0 | STN1 CTC1 TEN1 | DNA biosynthetic process |
| HP:0007495 | 0.0435644243888 | 0.666666666667 | CTC1 STN1 | Prematurely aged appearance |
| HP:0001009 | 0.0480420769795 | 0.666666666667 | CTC1 STN1 | Telangiectasia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TEN1 | STN1 | 0.857 | 0.794 | bioplex (STN1,TEN1) bioplex_WMM |
| CTC1 | STN1 | 0.683 | 0.711 | bioplex (STN1) bioplex_WMM |
| CTC1 | TEN1 | 0.13 | 0.401 | hein_WMM bioplex (TEN1) bioplex_WMM hein (TEN1) |
Images
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Complex HuMAP2_01050 has an average edge precision of 0.635 which is ranked 1744 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CTC1 | HuMAP2_01050 HuMAP2_01115 |
| TEN1 | HuMAP2_01050 HuMAP2_01115 HuMAP2_02935 |
| STN1 | HuMAP2_01050 HuMAP2_01115 HuMAP2_02935 |