hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01057

Confidence: High

Genename	Protein Name	Links
NOP58	Nucleolar protein 58 (Nucleolar protein 5)	UniProt NCBI
NOC3L	Nucleolar complex protein 3 homolog (NOC3 protein homolog) (Factor for adipocyte differentiation 24) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein)	UniProt NCBI
NOP2	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)	UniProt NCBI
RRP15	RRP15-like protein (Ribosomal RNA-processing protein 15)	UniProt NCBI
MRTO4	mRNA turnover protein 4 homolog (Ribosome assembly factor MRTO4)	UniProt NCBI
GTPBP4	Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)	UniProt NCBI
DDX18	ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb)	UniProt NCBI
DKC1	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)	UniProt NCBI
NOP56	Nucleolar protein 56 (Nucleolar protein 5A)	UniProt NCBI
PES1	Pescadillo homolog	UniProt NCBI
DDX24	ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005730	5.13000068247e-08	0.909090909091	DDX24 NOP2 NOP56 PES1 GTPBP4 MRTO4 DDX18 DKC1 NOC3L NOP58	nucleolus
GO:0006364	4.00791838573e-07	0.636363636364	DKC1 NOP56 PES1 NOP58 MRTO4 DDX18 NOP2	rRNA processing
GO:0016072	5.73905505782e-07	0.636363636364	DKC1 NOP56 PES1 NOP58 MRTO4 DDX18 NOP2	rRNA metabolic process
GO:0042254	3.48247614385e-06	0.636363636364	DKC1 NOP56 PES1 NOP58 MRTO4 DDX18 NOP2	ribosome biogenesis
KEGG:03008	9.54871378668e-06	0.363636363636	GTPBP4 NOP56 NOP58 DKC1	Ribosome biogenesis in eukaryotes
REAC:R-HSA-6790901	1.685878186e-05	0.363636363636	NOP56 DKC1 NOP2 NOP58	rRNA modification in the nucleus and cytosol
GO:0034470	2.71838840465e-05	0.636363636364	DKC1 NOP56 PES1 NOP58 MRTO4 DDX18 NOP2	ncRNA processing
REAC:R-HSA-8868773	3.13262040958e-05	0.454545454545	NOP56 PES1 NOP2 DKC1 NOP58	rRNA processing in the nucleus and cytosol
GO:0003723	3.22704440191e-05	0.909090909091	DDX24 NOP2 NOP56 PES1 GTPBP4 MRTO4 DDX18 DKC1 NOC3L NOP58	RNA binding
REAC:R-HSA-72312	4.04015463746e-05	0.454545454545	NOP56 PES1 NOP2 DKC1 NOP58	rRNA processing
GO:0030684	5.55613333118e-05	0.454545454545	NOP56 MRTO4 PES1 RRP15 NOP58	preribosome
GO:0022613	8.35959996597e-05	0.636363636364	DKC1 NOP56 PES1 NOP58 MRTO4 DDX18 NOP2	ribonucleoprotein complex biogenesis
GO:0034660	0.000146378521185	0.636363636364	DKC1 NOP56 PES1 NOP58 MRTO4 DDX18 NOP2	ncRNA metabolic process
GO:0042273	0.00469004521715	0.363636363636	DDX18 PES1 NOP2 MRTO4	ribosomal large subunit biogenesis
GO:0003676	0.00902997612677	0.909090909091	DDX24 NOP2 NOP56 PES1 GTPBP4 MRTO4 DDX18 DKC1 NOC3L NOP58	nucleic acid binding
HPA:022020_13	0.0126018485717	0.363636363636	PES1 NOP2 DKC1 NOP58	hippocampus; neuronal cells[Supported,High]
REAC:R-HSA-8953854	0.0128710237229	0.454545454545	NOP56 PES1 NOP2 DKC1 NOP58	Metabolism of RNA
GO:0006396	0.0134479288239	0.636363636364	DKC1 NOP56 PES1 NOP58 MRTO4 DDX18 NOP2	RNA processing
GO:0005732	0.0144271800391	0.272727272727	NOP56 NOP58 DKC1	small nucleolar ribonucleoprotein complex
GO:0030687	0.0263254502884	0.272727272727	PES1 RRP15 MRTO4	preribosome, large subunit precursor
GO:0030515	0.0263254502884	0.272727272727	NOP56 NOP58 DKC1	snoRNA binding

Edges

Protein 1	Protein 2	Score	Precision	Evidence
NOP56	NOP58	1.0	0.949	hein_WMM bioplex_WMM Guru youn_WMM hein (NOP56) Malo gupta_WMM fraction treiber_WMM
DKC1	NOP2	1.0	0.949	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
NOP56	NOP2	1.0	0.949	hein_WMM bioplex_WMM Guru youn_WMM hein (NOP56) gupta_WMM fraction treiber_WMM
MRTO4	NOP2	0.999	0.949	hein_WMM bioplex (MRTO4) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DKC1	NOP56	0.997	0.929	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
PES1	NOP2	0.996	0.926	hein_WMM bioplex (PES1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
GTPBP4	NOP2	0.979	0.895	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DDX18	GTPBP4	0.978	0.893	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRP15	NOP2	0.973	0.886	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction
RRP15	NOP56	0.962	0.87	hein_WMM bioplex_WMM youn_WMM hein (NOP56) gupta_WMM fraction treiber_WMM
DKC1	NOP58	0.955	0.862	bioplex (DKC1) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
GTPBP4	NOP56	0.95	0.857	hein_WMM bioplex_WMM Guru youn_WMM hein (NOP56) gupta_WMM fraction treiber_WMM
DKC1	RRP15	0.947	0.857	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DDX18	NOP2	0.821	0.773	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
NOP56	DDX24	0.809	0.77	hein_WMM bioplex_WMM Guru youn_WMM hein (NOP56) gupta_WMM fraction treiber_WMM
DKC1	GTPBP4	0.792	0.758	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DKC1	DDX24	0.766	0.749	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DDX24	NOP2	0.7	0.722	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DDX18	NOP56	0.683	0.711	hein_WMM bioplex_WMM Guru youn_WMM hein (NOP56) gupta_WMM fraction treiber_WMM
MRTO4	RRP15	0.682	0.709	hein_WMM bioplex (MRTO4) bioplex_WMM Guru youn_WMM fraction treiber_WMM
NOP2	NOC3L	0.664	0.698	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
MRTO4	GTPBP4	0.522	0.634	hein_WMM bioplex (MRTO4) bioplex_WMM youn_WMM gupta_WMM fraction
GTPBP4	NOP58	0.461	0.599	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
MRTO4	PES1	0.451	0.595	hein_WMM bioplex (MRTO4,PES1) bioplex_WMM youn_WMM gupta_WMM fraction
GTPBP4	RRP15	0.432	0.578	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRP15	DDX24	0.396	0.556	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction
DKC1	PES1	0.314	0.508	bioplex (PES1) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DDX18	NOP58	0.277	0.485	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
GTPBP4	DDX24	0.147	0.409	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
PES1	NOC3L	0.146	0.409	bioplex (PES1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
MRTO4	DDX24	0.118	0.391	hein_WMM bioplex (MRTO4) bioplex_WMM youn_WMM gupta_WMM fraction
PES1	NOP58	0.113	0.382	hein_WMM bioplex (PES1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DKC1	MRTO4	0.102	0.366	bioplex (MRTO4) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
MRTO4	NOP56	0.1	0.36	hein_WMM bioplex (MRTO4) bioplex_WMM youn_WMM hein (NOP56) gupta_WMM fraction
NOP56	PES1	0.093	0.355	hein_WMM bioplex (PES1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DKC1	DDX18	0.083	0.349	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
NOP58	NOC3L	0.062	0.345	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
NOP2	NOP58	0.047	0.293	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRP15	PES1	0.041	0.271	bioplex (PES1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DDX18	MRTO4	0.038	0.265	hein_WMM bioplex (MRTO4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
GTPBP4	PES1	0.03	0.236	hein_WMM bioplex (PES1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DDX24	PES1	0.028	0.233	hein_WMM bioplex (PES1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRP15	NOC3L	0.028	0.231	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction
GTPBP4	NOC3L	0.026	0.219	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RRP15	NOP58	0.026	0.218	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
MRTO4	NOC3L	0.026	0.216	hein_WMM bioplex (MRTO4) bioplex_WMM youn_WMM gupta_WMM
DDX18	RRP15	0.025	0.213	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction
DDX18	DDX24	0.023	0.209	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DDX24	NOC3L	0.019	0.187	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DDX18	PES1	0.018	0.178	hein_WMM bioplex (PES1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
DDX18	NOC3L	0.009	0.107	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
DDX24	NOP58	0.008	0.064	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DKC1	NOC3L	0.007	0.012	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
NOP56	NOC3L	0.005	0.009	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
MRTO4	NOP58	0.0	0.009	hein_WMM bioplex (MRTO4) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM

Images

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Complex HuMAP2_01057 has an average edge precision of 0.512 which is ranked 2440 out of all 6965 complexes.

Related Complexes

Genename	Complexes
NOP58	HuMAP2_01057 HuMAP2_02420 HuMAP2_03778 HuMAP2_04028 HuMAP2_04502 HuMAP2_04574 HuMAP2_04828
NOC3L	HuMAP2_01057 HuMAP2_06731
NOP2	HuMAP2_00465 HuMAP2_00537 HuMAP2_01057 HuMAP2_01318 HuMAP2_02076 HuMAP2_02100 HuMAP2_02371 HuMAP2_02746 HuMAP2_05727
RRP15	HuMAP2_00275 HuMAP2_00465 HuMAP2_00537 HuMAP2_00574 HuMAP2_01057 HuMAP2_01318 HuMAP2_01509 HuMAP2_02076 HuMAP2_02100 HuMAP2_05727
MRTO4	HuMAP2_00236 HuMAP2_00465 HuMAP2_01057 HuMAP2_01318 HuMAP2_01531 HuMAP2_02100 HuMAP2_02911
GTPBP4	HuMAP2_00236 HuMAP2_00537 HuMAP2_01057 HuMAP2_02100 HuMAP2_04959 HuMAP2_05727 HuMAP2_06347
DDX18	HuMAP2_00236 HuMAP2_01057 HuMAP2_02100 HuMAP2_02371 HuMAP2_02899 HuMAP2_04199 HuMAP2_04959
DKC1	HuMAP2_00041 HuMAP2_00275 HuMAP2_00537 HuMAP2_01057 HuMAP2_01164 HuMAP2_01512 HuMAP2_01695 HuMAP2_02076 HuMAP2_03262 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
NOP56	HuMAP2_00275 HuMAP2_00610 HuMAP2_01057 HuMAP2_03778 HuMAP2_03902 HuMAP2_04199 HuMAP2_04502 HuMAP2_04505 HuMAP2_05196 HuMAP2_05727 HuMAP2_06347
PES1	HuMAP2_00325 HuMAP2_01057 HuMAP2_01344 HuMAP2_01531 HuMAP2_02420 HuMAP2_04175 HuMAP2_04828
DDX24	HuMAP2_00275 HuMAP2_00537 HuMAP2_01057 HuMAP2_04505 HuMAP2_05439 HuMAP2_05727

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01057