hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01065
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATP6V1A | V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) | UniProt NCBI |
| ATP6V1B2 | V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2) | UniProt NCBI |
| ATP6V0D1 | V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1) | UniProt NCBI |
| ATP6V1D | V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 2.28595445261e-10 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Collecting duct acid secretion |
| REAC:R-HSA-77387 | 9.63670018313e-10 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Insulin receptor recycling |
| REAC:R-HSA-917977 | 2.15397389469e-09 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Transferrin endocytosis and recycling |
| REAC:R-HSA-1222556 | 3.26120589672e-09 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | ROS and RNS production in phagocytes |
| KEGG:05110 | 3.5162135762e-09 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Vibrio cholerae infection |
| KEGG:05323 | 6.6372190585e-09 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Rheumatoid arthritis |
| KEGG:05120 | 9.43033012544e-09 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04721 | 1.38508961964e-08 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Synaptic vesicle cycle |
| REAC:R-HSA-917937 | 2.86807459968e-08 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Iron uptake and transport |
| GO:0046961 | 3.32999412455e-08 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | proton-transporting ATPase activity, rotational mechanism |
| REAC:R-HSA-74752 | 4.12752946315e-08 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Signaling by Insulin receptor |
| KEGG:00190 | 1.38672231517e-07 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Oxidative phosphorylation |
| KEGG:04145 | 2.39127731928e-07 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Phagosome |
| CORUM:6888 | 2.4564793089e-07 | 0.75 | ATP6V1B2 ATP6V0D1 ATP6V1A | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| GO:0044769 | 3.08603851103e-07 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism |
| GO:0090383 | 4.28142101727e-07 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | phagosome acidification |
| GO:0033572 | 9.98266370523e-07 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | transferrin transport |
| GO:0009678 | 1.27735159239e-06 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | pyrophosphate hydrolysis-driven proton transmembrane transporter activity |
| GO:0090382 | 1.43702054144e-06 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | phagosome maturation |
| REAC:R-HSA-983712 | 2.38463075313e-06 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Ion channel transport |
| GO:0051452 | 2.47053849812e-06 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | intracellular pH reduction |
| GO:0045851 | 2.73059518213e-06 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | pH reduction |
| KEGG:05165 | 6.99843546146e-06 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Human papillomavirus infection |
| GO:0019829 | 7.71512067313e-06 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | ATPase-coupled cation transmembrane transporter activity |
| GO:0006826 | 8.3202281769e-06 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | iron ion transport |
| GO:0042625 | 1.03503048148e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | ATPase-coupled ion transmembrane transporter activity |
| GO:0051453 | 1.86987098651e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | regulation of intracellular pH |
| GO:0030641 | 2.10899871844e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | regulation of cellular pH |
| GO:0006885 | 2.50979095633e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | regulation of pH |
| GO:0030004 | 4.05878712438e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cellular monovalent inorganic cation homeostasis |
| GO:0000041 | 4.70712600242e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | transition metal ion transport |
| GO:0008286 | 7.43942887385e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | insulin receptor signaling pathway |
| GO:0015078 | 8.10410789889e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | proton transmembrane transporter activity |
| GO:0042626 | 8.45267167948e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | ATPase-coupled transmembrane transporter activity |
| GO:0015399 | 9.96052473331e-05 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | primary active transmembrane transporter activity |
| REAC:R-HSA-9006934 | 0.00010216546718 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Signaling by Receptor Tyrosine Kinases |
| GO:0055067 | 0.000116616394242 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | monovalent inorganic cation homeostasis |
| KEGG:04150 | 0.00013020910184 | 0.75 | ATP6V1B2 ATP6V1A ATP6V1D | mTOR signaling pathway |
| GO:0032869 | 0.000384893528585 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cellular response to insulin stimulus |
| GO:0016241 | 0.000419088323416 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | regulation of macroautophagy |
| GO:0032868 | 0.000468165581659 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | response to insulin |
| REAC:R-HSA-382551 | 0.000491356075286 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Transport of small molecules |
| GO:0022853 | 0.00100892420578 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | active ion transmembrane transporter activity |
| GO:0071375 | 0.0014249330287 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cellular response to peptide hormone stimulus |
| KEGG:01100 | 0.00203701694021 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Metabolic pathways |
| GO:0043434 | 0.00231676827382 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | response to peptide hormone |
| REAC:R-HSA-168249 | 0.00243001134371 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Innate Immune System |
| GO:1901653 | 0.00291933071066 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cellular response to peptide |
| GO:0022804 | 0.00297010167954 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | active transmembrane transporter activity |
| GO:0016469 | 0.00386509246613 | 0.75 | ATP6V1D ATP6V0D1 ATP6V1A | proton-transporting two-sector ATPase complex |
| GO:0016236 | 0.004264164573 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | macroautophagy |
| GO:0015077 | 0.00460927796737 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | monovalent inorganic cation transmembrane transporter activity |
| GO:0010506 | 0.0047530290566 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | regulation of autophagy |
| GO:0005765 | 0.00482615258054 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | lysosomal membrane |
| GO:0098852 | 0.00482615258054 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | lytic vacuole membrane |
| GO:1901652 | 0.00512711596139 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | response to peptide |
| GO:0005774 | 0.00806983640441 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | vacuolar membrane |
| GO:0071417 | 0.0191533398135 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cellular response to organonitrogen compound |
| GO:0061919 | 0.0243708967076 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | process utilizing autophagic mechanism |
| GO:0006914 | 0.0243708967076 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | autophagy |
| GO:0030003 | 0.0258916606244 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cellular cation homeostasis |
| GO:0032870 | 0.0274825106713 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cellular response to hormone stimulus |
| GO:0006873 | 0.0277546147374 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cellular ion homeostasis |
| GO:1901699 | 0.0297163373299 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cellular response to nitrogen compound |
| GO:0022890 | 0.0308829845728 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | inorganic cation transmembrane transporter activity |
| REAC:R-HSA-168256 | 0.0358063812597 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | Immune System |
| GO:0044437 | 0.0375813449419 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | vacuolar part |
| GO:0055080 | 0.0382716890733 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cation homeostasis |
| GO:0098771 | 0.0403998712414 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | inorganic ion homeostasis |
| GO:0008324 | 0.0433740392707 | 1.0 | ATP6V1B2 ATP6V1A ATP6V0D1 ATP6V1D | cation transmembrane transporter activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP6V1B2 | ATP6V1A | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction treiber_WMM |
| ATP6V0D1 | ATP6V1B2 | 0.924 | 0.844 | hein_WMM bioplex (ATP6V0D1) bioplex_WMM Guru fraction |
| ATP6V1B2 | ATP6V1D | 0.852 | 0.791 | hein_WMM bioplex_WMM Guru fraction |
| ATP6V0D1 | ATP6V1A | 0.75 | 0.743 | hein_WMM bioplex (ATP6V0D1) bioplex_WMM Guru fraction |
| ATP6V1A | ATP6V1D | 0.147 | 0.408 | hein_WMM bioplex_WMM Guru fraction |
| ATP6V0D1 | ATP6V1D | 0.11 | 0.379 | hein_WMM bioplex (ATP6V0D1) bioplex_WMM fraction |
Images
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Complex HuMAP2_01065 has an average edge precision of 0.686 which is ranked 1435 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATP6V1A | HuMAP2_00849 HuMAP2_01065 HuMAP2_01514 HuMAP2_04825 HuMAP2_05288 HuMAP2_05478 HuMAP2_06925 |
| ATP6V1B2 | HuMAP2_00772 HuMAP2_01065 HuMAP2_01514 HuMAP2_06925 |
| ATP6V0D1 | HuMAP2_00515 HuMAP2_00772 HuMAP2_01018 HuMAP2_01065 HuMAP2_01270 HuMAP2_02034 HuMAP2_02651 HuMAP2_04677 HuMAP2_06925 |
| ATP6V1D | HuMAP2_01065 HuMAP2_01165 HuMAP2_05625 HuMAP2_06925 |