hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01066
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MTREX | Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) | UniProt NCBI |
| NCBP1 | Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) | UniProt NCBI |
| NCBP2 | Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) | UniProt NCBI |
| TTC4 | Tetratricopeptide repeat protein 4 (TPR repeat protein 4) | UniProt NCBI |
| NUDC | Nuclear migration protein nudC (Nuclear distribution protein C homolog) | UniProt NCBI |
| CAPN11 | Calpain-11 (EC 3.4.22.-) (Calcium-activated neutral proteinase 11) (CANP 11) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:775 | 8.39001385941e-06 | 0.333333333333 | NCBP1 NCBP2 | CBC complex (cap binding complex) |
| CORUM:1172 | 8.39001385941e-06 | 0.333333333333 | NCBP1 NCBP2 | CBC complex (cap binding complex) |
| CORUM:1174 | 2.51655344529e-05 | 0.333333333333 | NCBP1 NCBP2 | PHAX-CBC complex (cap binding complex) |
| CORUM:1176 | 8.38550741504e-05 | 0.333333333333 | NCBP1 NCBP2 | CRM1-RAN-PHAX-CBC complex (cap binding complex) |
| CORUM:6129 | 0.000125760085813 | 0.333333333333 | NCBP1 NCBP2 | CBP80/20- dependent translation complex |
| CORUM:351 | 0.000987922291724 | 0.5 | NCBP2 NCBP1 MTREX | Spliceosome |
| REAC:R-HSA-111367 | 0.000996295422965 | 0.333333333333 | NCBP1 NCBP2 | SLBP independent Processing of Histone Pre-mRNAs |
| REAC:R-HSA-77588 | 0.0012174763081 | 0.333333333333 | NCBP1 NCBP2 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| REAC:R-HSA-8851708 | 0.00377982352449 | 0.333333333333 | NCBP1 NCBP2 | Signaling by FGFR2 IIIa TM |
| REAC:R-HSA-77595 | 0.00377982352449 | 0.333333333333 | NCBP1 NCBP2 | Processing of Intronless Pre-mRNAs |
| REAC:R-HSA-72163 | 0.00535958541971 | 0.5 | NCBP2 NCBP1 MTREX | mRNA Splicing - Major Pathway |
| REAC:R-HSA-167242 | 0.0055883638448 | 0.333333333333 | NCBP1 NCBP2 | Abortive elongation of HIV-1 transcript in the absence of Tat |
| REAC:R-HSA-72172 | 0.00611221514505 | 0.5 | NCBP2 NCBP1 MTREX | mRNA Splicing |
| REAC:R-HSA-1839126 | 0.00662414399653 | 0.333333333333 | NCBP1 NCBP2 | FGFR2 mutant receptor activation |
| GO:0005846 | 0.00676235117068 | 0.333333333333 | NCBP1 NCBP2 | nuclear cap binding complex |
| REAC:R-HSA-6803529 | 0.00717487015656 | 0.333333333333 | NCBP1 NCBP2 | FGFR2 alternative splicing |
| REAC:R-HSA-75067 | 0.00834193552282 | 0.333333333333 | NCBP1 NCBP2 | Processing of Capped Intronless Pre-mRNA |
| REAC:R-HSA-72086 | 0.00895825109095 | 0.333333333333 | NCBP1 NCBP2 | mRNA Capping |
| REAC:R-HSA-159227 | 0.00959640616298 | 0.333333333333 | NCBP1 NCBP2 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-159230 | 0.0102563889288 | 0.333333333333 | NCBP1 NCBP2 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-167158 | 0.0116417903194 | 0.333333333333 | NCBP1 NCBP2 | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-113418 | 0.0116417903194 | 0.333333333333 | NCBP1 NCBP2 | Formation of the Early Elongation Complex |
| REAC:R-HSA-72203 | 0.0122769600403 | 0.5 | NCBP2 NCBP1 MTREX | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-5655253 | 0.012367185342 | 0.333333333333 | NCBP1 NCBP2 | Signaling by FGFR2 in disease |
| REAC:R-HSA-159231 | 0.0146740061797 | 0.333333333333 | NCBP1 NCBP2 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.0154864524203 | 0.333333333333 | NCBP1 NCBP2 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-167200 | 0.0208171179433 | 0.333333333333 | NCBP1 NCBP2 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167169 | 0.0208171179433 | 0.333333333333 | NCBP1 NCBP2 | HIV Transcription Elongation |
| REAC:R-HSA-167246 | 0.0208171179433 | 0.333333333333 | NCBP1 NCBP2 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167152 | 0.0227674337622 | 0.333333333333 | NCBP1 NCBP2 | Formation of HIV elongation complex in the absence of HIV Tat |
| KEGG:03015 | 0.0236020276363 | 0.333333333333 | NCBP1 NCBP2 | mRNA surveillance pathway |
| REAC:R-HSA-194441 | 0.0269276420577 | 0.333333333333 | NCBP1 NCBP2 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 0.0269276420577 | 0.333333333333 | NCBP1 NCBP2 | snRNP Assembly |
| REAC:R-HSA-72165 | 0.029137346631 | 0.333333333333 | NCBP1 NCBP2 | mRNA Splicing - Minor Pathway |
| REAC:R-HSA-1226099 | 0.0302745579484 | 0.333333333333 | NCBP1 NCBP2 | Signaling by FGFR in disease |
| REAC:R-HSA-72187 | 0.0314333263146 | 0.333333333333 | NCBP1 NCBP2 | mRNA 3'-end processing |
| REAC:R-HSA-5654738 | 0.036283735834 | 0.333333333333 | NCBP1 NCBP2 | Signaling by FGFR2 |
| REAC:R-HSA-75955 | 0.0375501136505 | 0.333333333333 | NCBP1 NCBP2 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 0.0375501136505 | 0.333333333333 | NCBP1 NCBP2 | Formation of RNA Pol II elongation complex |
| WP:WP411 | 0.0423673641592 | 0.333333333333 | NCBP1 NCBP2 | mRNA Processing |
| REAC:R-HSA-73856 | 0.0428303754683 | 0.333333333333 | NCBP1 NCBP2 | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-190236 | 0.0484536768126 | 0.333333333333 | NCBP1 NCBP2 | Signaling by FGFR |
| REAC:R-HSA-159236 | 0.0499130144295 | 0.333333333333 | NCBP1 NCBP2 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| CORUM:1190 | 0.0499726005494 | 0.166666666667 | NCBP1 | NCBP-NIP1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NCBP2 | MTREX | 0.968 | 0.88 | hein_WMM youn (NCBP2) bioplex_WMM youn_WMM hein (NCBP2) fraction |
| MTREX | NCBP1 | 0.329 | 0.519 | hein_WMM bioplex_WMM youn_WMM hein (NCBP1) gupta_WMM fraction treiber_WMM |
| MTREX | NUDC | 0.062 | 0.342 | bioplex_WMM youn_WMM gupta_WMM fraction |
| MTREX | TTC4 | 0.059 | 0.328 | bioplex_WMM youn_WMM gupta_WMM fraction |
| NCBP2 | NCBP1 | 0.048 | 0.293 | hein_WMM youn (NCBP2) bioplex_WMM Guru youn_WMM hein (NCBP1,NCBP2) fraction |
| MTREX | CAPN11 | 0.047 | 0.292 | fraction |
| NCBP2 | NUDC | 0.007 | 0.009 | youn (NCBP2) bioplex_WMM youn_WMM |
| TTC4 | NUDC | 0.007 | 0.006 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NCBP1 | NUDC | 0.007 | 0.003 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| NCBP1 | CAPN11 | 0.007 | 0.002 | bioplex (CAPN11) |
| NCBP1 | TTC4 | 0.0 | 0.01 | bioplex_WMM youn_WMM fraction |
Images
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Complex HuMAP2_01066 has an average edge precision of 0.244 which is ranked 5472 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MTREX | HuMAP2_00359 HuMAP2_01066 HuMAP2_06283 |
| NCBP1 | HuMAP2_00427 HuMAP2_01066 HuMAP2_06019 HuMAP2_06277 |
| NCBP2 | HuMAP2_00359 HuMAP2_00427 HuMAP2_01066 HuMAP2_06019 HuMAP2_06262 HuMAP2_06277 HuMAP2_06561 |
| TTC4 | HuMAP2_01066 HuMAP2_02102 HuMAP2_02616 HuMAP2_06283 HuMAP2_06348 |
| NUDC | HuMAP2_01066 HuMAP2_03995 |
| CAPN11 | HuMAP2_01066 HuMAP2_03142 HuMAP2_06283 |