hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01067
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CHM | Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) | UniProt NCBI |
| CHML | Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2) | UniProt NCBI |
| RAB31 | Ras-related protein Rab-31 (Ras-related protein Rab-22B) | UniProt NCBI |
| RAB9A | Ras-related protein Rab-9A | UniProt NCBI |
| RABGGTA | Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8873719 | 1.58712520861e-10 | 1.0 | CHM RAB9A RAB31 RABGGTA CHML | RAB geranylgeranylation |
| REAC:R-HSA-8876198 | 7.36239529367e-07 | 0.8 | CHM RAB9A RAB31 CHML | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-9007101 | 2.59920773791e-06 | 0.8 | CHM RAB9A RAB31 CHML | Rab regulation of trafficking |
| GO:0005968 | 3.6323771075e-06 | 0.6 | CHM RABGGTA CHML | Rab-protein geranylgeranyltransferase complex |
| CORUM:6956 | 2.0123342217e-05 | 0.4 | CHM RABGGTA | REP-RGGT-Rab complex |
| GO:0018344 | 3.17736949706e-05 | 0.6 | CHM RABGGTA CHML | protein geranylgeranylation |
| GO:0018342 | 7.62415024416e-05 | 0.6 | CHM RABGGTA CHML | protein prenylation |
| GO:0097354 | 7.62415024416e-05 | 0.6 | CHM RABGGTA CHML | prenylation |
| REAC:R-HSA-597592 | 0.000641406598892 | 1.0 | CHM RAB9A RAB31 RABGGTA CHML | Post-translational protein modification |
| REAC:R-HSA-6803205 | 0.00105126658749 | 0.4 | CHM RABGGTA | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| REAC:R-HSA-199991 | 0.00166286547268 | 0.8 | CHM RAB9A RAB31 CHML | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0020580612036 | 0.8 | CHM RAB9A RAB31 CHML | Vesicle-mediated transport |
| REAC:R-HSA-392499 | 0.0039377533293 | 1.0 | CHM RAB9A RAB31 RABGGTA CHML | Metabolism of proteins |
| REAC:R-HSA-5633008 | 0.0104745816743 | 0.4 | CHM RABGGTA | TP53 Regulates Transcription of Cell Death Genes |
| GO:0004663 | 0.0135228859698 | 0.4 | CHM RABGGTA | Rab geranylgeranyltransferase activity |
| GO:0004661 | 0.0450641792523 | 0.4 | CHM RABGGTA | protein geranylgeranyltransferase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CHML | RAB31 | 0.52 | 0.633 | bioplex (RAB31) bioplex_WMM |
| CHM | RAB31 | 0.401 | 0.561 | bioplex (RAB31) bioplex_WMM |
| RABGGTA | RAB31 | 0.275 | 0.487 | bioplex (RAB31) bioplex_WMM |
| CHM | CHML | 0.099 | 0.358 | bioplex_WMM WMM_only boldt_WMM |
| CHML | RAB9A | 0.085 | 0.348 | bioplex (RAB9A) bioplex_WMM youn_WMM |
| CHML | RABGGTA | 0.052 | 0.302 | bioplex (RABGGTA) bioplex_WMM |
| CHM | RAB9A | 0.043 | 0.268 | bioplex (RAB9A) bioplex_WMM |
| CHM | RABGGTA | 0.04 | 0.268 | bioplex (RABGGTA) bioplex_WMM |
| RABGGTA | RAB9A | 0.014 | 0.138 | bioplex (RAB9A) bioplex_WMM |
| RAB31 | RAB9A | 0.009 | 0.106 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_01067 has an average edge precision of 0.347 which is ranked 4036 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CHM | HuMAP2_01067 HuMAP2_02250 HuMAP2_03796 HuMAP2_07002 |
| CHML | HuMAP2_01067 HuMAP2_03796 HuMAP2_04752 HuMAP2_07002 |
| RAB31 | HuMAP2_01067 HuMAP2_03796 HuMAP2_04471 HuMAP2_04752 HuMAP2_07002 |
| RAB9A | HuMAP2_01067 HuMAP2_03796 HuMAP2_07002 |
| RABGGTA | HuMAP2_01067 HuMAP2_02113 HuMAP2_03796 HuMAP2_07002 |