hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01077
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TPM1 | Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) | UniProt NCBI |
| MYH7B | Myosin-7B (Antigen MLAA-21) (Myosin cardiac muscle beta chain) (Myosin heavy chain 7B, cardiac muscle beta isoform) (Slow A MYH14) | UniProt NCBI |
| MYH1 | Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1) | UniProt NCBI |
| TPM3 | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) | UniProt NCBI |
| MYH8 | Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP383 | 5.20922719206e-06 | 0.6 | TPM1 TPM3 MYH8 | Striated Muscle Contraction Pathway |
| REAC:R-HSA-390522 | 1.77393158174e-05 | 0.6 | TPM1 TPM3 MYH8 | Striated Muscle Contraction |
| KEGG:04530 | 0.000424294655338 | 0.6 | MYH7B MYH8 MYH1 | Tight junction |
| KEGG:05130 | 0.000772172961031 | 0.6 | MYH7B MYH8 MYH1 | Pathogenic Escherichia coli infection |
| GO:0044449 | 0.00155534683144 | 0.8 | TPM1 MYH8 TPM3 MYH1 | contractile fiber part |
| GO:0043292 | 0.00191030232031 | 0.8 | TPM1 MYH8 TPM3 MYH1 | contractile fiber |
| REAC:R-HSA-397014 | 0.00222754987811 | 0.6 | TPM1 TPM3 MYH8 | Muscle contraction |
| REAC:R-HSA-445355 | 0.00709716303977 | 0.4 | TPM1 TPM3 | Smooth Muscle Contraction |
| GO:0030049 | 0.00763446836913 | 0.6 | TPM1 TPM3 MYH8 | muscle filament sliding |
| GO:0033275 | 0.00763446836913 | 0.6 | TPM1 TPM3 MYH8 | actin-myosin filament sliding |
| KEGG:04260 | 0.0121154716042 | 0.4 | TPM1 TPM3 | Cardiac muscle contraction |
| KEGG:05410 | 0.0137641082753 | 0.4 | TPM1 TPM3 | Hypertrophic cardiomyopathy (HCM) |
| KEGG:05414 | 0.0151578406027 | 0.4 | TPM1 TPM3 | Dilated cardiomyopathy (DCM) |
| GO:0005862 | 0.0270421395626 | 0.4 | TPM1 TPM3 | muscle thin filament tropomyosin |
| KEGG:04261 | 0.0348468299156 | 0.4 | TPM1 TPM3 | Adrenergic signaling in cardiomyocytes |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TPM1 | TPM3 | 1.0 | 0.949 | hein_WMM bioplex (TPM1) bioplex_WMM boldt youn_WMM hein (TPM1) gupta_WMM fraction boldt_WMM treiber_WMM |
| MYH7B | TPM3 | 0.969 | 0.88 | Guru fraction |
| TPM1 | MYH7B | 0.939 | 0.851 | Guru fraction |
| TPM1 | MYH1 | 0.824 | 0.773 | bioplex_WMM Guru fraction |
| TPM1 | MYH8 | 0.749 | 0.743 | bioplex_WMM Guru fraction |
| MYH1 | MYH8 | 0.01 | 0.126 | bioplex_WMM WMM_only |
| MYH1 | TPM3 | 0.007 | 0.008 | bioplex_WMM WMM_only boldt_WMM |
Images
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Complex HuMAP2_01077 has an average edge precision of 0.619 which is ranked 1843 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TPM1 | HuMAP2_01077 HuMAP2_04204 HuMAP2_06151 HuMAP2_06387 |
| MYH7B | HuMAP2_01077 HuMAP2_04204 HuMAP2_06710 |
| MYH1 | HuMAP2_01077 HuMAP2_05532 |
| TPM3 | HuMAP2_01077 HuMAP2_01543 HuMAP2_04204 HuMAP2_06151 |
| MYH8 | HuMAP2_01077 HuMAP2_02631 HuMAP2_05532 |