hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01079
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PHLPP1 | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | UniProt NCBI |
| VSX2 | Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) | UniProt NCBI |
| WDR48 | WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80) | UniProt NCBI |
| DMWD | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9) | UniProt NCBI |
| RAD51AP1 | RAD51-associated protein 1 (RAD51-interacting protein) | UniProt NCBI |
| USP46 | Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) | UniProt NCBI |
| WDR20 | WD repeat-containing protein 20 (Protein DMR) | UniProt NCBI |
| USP1 | Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6635 | 4.70911134935e-09 | 0.375 | WDR20 USP46 WDR48 | WDR20-USP46-UAF1 complex |
| CORUM:6521 | 1.64652925394e-07 | 0.375 | PHLPP1 WDR48 USP1 | Akt-PHLPP1-PHLPP2-FANCI-FANCD2-USP1-UAF1 complex |
| CORUM:3176 | 1.16880143691e-05 | 0.25 | WDR48 USP1 | USP1-UAF1 complex |
| CORUM:6637 | 1.16880143691e-05 | 0.25 | USP46 WDR48 | USP46-UAF1 complex |
| CORUM:6638 | 1.16880143691e-05 | 0.25 | WDR48 USP1 | USP1-UAF1 complex |
| CORUM:6634 | 3.50546248845e-05 | 0.25 | WDR20 WDR48 | WDR20-USP12-UAF1 complex |
| KEGG:03460 | 0.0140946078948 | 0.25 | WDR48 USP1 | Fanconi anemia pathway |
| REAC:R-HSA-110314 | 0.0193257881708 | 0.25 | WDR48 USP1 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-6783310 | 0.0263986242322 | 0.25 | WDR48 USP1 | Fanconi Anemia Pathway |
| REAC:R-HSA-73893 | 0.047806738235 | 0.25 | WDR48 USP1 | DNA Damage Bypass |
| CORUM:6636 | 0.0497224828424 | 0.125 | WDR48 | USP12-UAF1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WDR20 | WDR48 | 0.92 | 0.844 | hein_WMM bioplex (WDR20) bioplex_WMM boldt hein (WDR48) gupta_WMM boldt_WMM |
| USP46 | DMWD | 0.893 | 0.819 | bioplex (USP46) bioplex_WMM |
| USP46 | WDR48 | 0.72 | 0.732 | bioplex (USP46) bioplex_WMM boldt gupta_WMM boldt_WMM |
| USP46 | WDR20 | 0.67 | 0.704 | bioplex (USP46,WDR20) bioplex_WMM boldt gupta_WMM boldt_WMM |
| WDR48 | USP1 | 0.18 | 0.437 | hein_WMM bioplex (USP1) bioplex_WMM hein (WDR48) boldt_WMM |
| WDR48 | RAD51AP1 | 0.073 | 0.354 | bioplex (RAD51AP1) bioplex_WMM |
| VSX2 | WDR20 | 0.061 | 0.339 | bioplex (VSX2) bioplex_WMM |
| PHLPP1 | USP46 | 0.027 | 0.23 | bioplex (USP46) bioplex_WMM |
| USP46 | RAD51AP1 | 0.013 | 0.144 | bioplex (RAD51AP1) bioplex_WMM |
| PHLPP1 | DMWD | 0.009 | 0.093 | bioplex_WMM WMM_only |
| WDR20 | DMWD | 0.008 | 0.082 | hein_WMM bioplex_WMM WMM_only |
| PHLPP1 | WDR48 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| PHLPP1 | WDR20 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| USP1 | DMWD | 0.007 | 0.0 | hein_WMM bioplex_WMM WMM_only |
| WDR20 | USP1 | 0.007 | 0.001 | hein_WMM bioplex_WMM WMM_only |
| USP46 | USP1 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| WDR48 | DMWD | 0.006 | 0.003 | hein_WMM bioplex_WMM hein (WDR48) |
| PHLPP1 | USP1 | 0.004 | 0.009 | bioplex (USP1) bioplex_WMM |
| VSX2 | WDR48 | 0.0 | 0.014 | bioplex (VSX2) bioplex_WMM |
| USP1 | RAD51AP1 | 0.0 | 0.01 | bioplex (RAD51AP1) bioplex_WMM |
Images
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Complex HuMAP2_01079 has an average edge precision of 0.246 which is ranked 5429 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PHLPP1 | HuMAP2_00810 HuMAP2_01079 HuMAP2_03555 |
| VSX2 | HuMAP2_01079 HuMAP2_06059 |
| WDR48 | HuMAP2_01079 HuMAP2_01858 HuMAP2_04664 HuMAP2_05585 HuMAP2_06059 |
| DMWD | HuMAP2_01079 HuMAP2_01772 HuMAP2_01858 HuMAP2_06059 |
| RAD51AP1 | HuMAP2_01079 HuMAP2_04664 HuMAP2_06059 |
| USP46 | HuMAP2_01079 HuMAP2_01772 HuMAP2_01858 HuMAP2_06059 |
| WDR20 | HuMAP2_01079 HuMAP2_01858 HuMAP2_04145 HuMAP2_05585 HuMAP2_06059 |
| USP1 | HuMAP2_01079 HuMAP2_04664 HuMAP2_06059 |