hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01080
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NBN | Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1) | UniProt NCBI |
| MRE11 | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | UniProt NCBI |
| HEATR1 | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | UniProt NCBI |
| FAM219A | Protein FAM219A | UniProt NCBI |
| RAD50 | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:173 | 1.35146690511e-09 | 0.6 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:73 | 1.35146690511e-09 | 0.6 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:618 | 1.35146690511e-09 | 0.6 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:2767 | 1.35146690511e-09 | 0.6 | RAD50 NBN MRE11 | RAD50-MRE11-NBN-p200-p350 complex |
| CORUM:972 | 1.35146690511e-09 | 0.6 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:1081 | 1.35146690511e-09 | 0.6 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:331 | 1.35146690511e-09 | 0.6 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:71 | 1.35146690511e-09 | 0.6 | RAD50 NBN MRE11 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:202 | 5.40532307664e-09 | 0.6 | RAD50 NBN MRE11 | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:619 | 5.40532307664e-09 | 0.6 | RAD50 NBN MRE11 | MRE11A-RAD50-NBN-TRF2 complex |
| CORUM:2218 | 5.40532307664e-09 | 0.6 | RAD50 NBN MRE11 | MDC1-MRE11-RAD50-NBS1 complex |
| CORUM:964 | 5.40532307664e-09 | 0.6 | RAD50 NBN MRE11 | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:627 | 5.40532307664e-09 | 0.6 | RAD50 NBN MRE11 | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) |
| WP:WP2942 | 2.35360703486e-08 | 0.6 | RAD50 NBN MRE11 | DDX1 as a regulatory component of the Drosha microprocessor |
| CORUM:2217 | 2.70211703843e-08 | 0.6 | RAD50 NBN MRE11 | MDC1-MRN-ATM-FANCD2 complex |
| CORUM:5197 | 2.70211703843e-08 | 0.6 | RAD50 NBN MRE11 | PTIP-DNA damage response complex |
| CORUM:1189 | 4.72822841824e-08 | 0.6 | RAD50 NBN MRE11 | DNA double-strand break end-joining complex |
| REAC:R-HSA-5693548 | 5.43659475995e-08 | 0.6 | RAD50 NBN MRE11 | Sensing of DNA Double Strand Breaks |
| CORUM:2815 | 7.56440327173e-08 | 0.6 | RAD50 NBN MRE11 | BRCA1-BARD1-BACH1-DNA damage complex II |
| WP:WP186 | 1.47866495656e-07 | 0.6 | RAD50 NBN MRE11 | Homologous recombination |
| CORUM:433 | 2.97053227881e-07 | 0.6 | RAD50 NBN MRE11 | BASC complex (BRCA1-associated genome surveillance complex) |
| REAC:R-HSA-5685939 | 3.26064244298e-07 | 0.6 | RAD50 NBN MRE11 | HDR through MMEJ (alt-NHEJ) |
| HP:0030406 | 3.40426201827e-06 | 0.6 | RAD50 NBN MRE11 | Primary peritoneal carcinoma |
| GO:0031860 | 3.6323771075e-06 | 0.6 | RAD50 NBN MRE11 | telomeric 3' overhang formation |
| WP:WP2516 | 6.12580709064e-06 | 0.6 | RAD50 NBN MRE11 | ATM Signaling Pathway |
| CORUM:263 | 6.70868171695e-06 | 0.4 | RAD50 MRE11 | R/M complex (RAD50-MRE11 complex) |
| CORUM:72 | 6.70868171695e-06 | 0.4 | RAD50 MRE11 | R/M complex (RAD50-MRE11 complex) |
| CORUM:264 | 6.70868171695e-06 | 0.4 | RAD50 MRE11 | R/M complex (RAD50-MRE11 complex) |
| REAC:R-HSA-5693554 | 7.0533398358e-06 | 0.6 | RAD50 NBN MRE11 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| KEGG:03440 | 8.5137761885e-06 | 0.6 | RAD50 NBN MRE11 | Homologous recombination |
| WP:WP3878 | 8.87288130353e-06 | 0.6 | RAD50 NBN MRE11 | ATM Signaling Network in Development and Disease |
| REAC:R-HSA-5693568 | 1.34474619847e-05 | 0.6 | RAD50 NBN MRE11 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 1.47907161009e-05 | 0.6 | RAD50 NBN MRE11 | Resolution of D-Loop Structures |
| WP:WP3959 | 1.75567562841e-05 | 0.6 | RAD50 NBN MRE11 | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| REAC:R-HSA-5685938 | 1.93500285918e-05 | 0.6 | RAD50 NBN MRE11 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 2.28576897279e-05 | 0.6 | RAD50 NBN MRE11 | Presynaptic phase of homologous DNA pairing and strand exchange |
| HP:0011027 | 2.42867577851e-05 | 0.6 | RAD50 NBN MRE11 | Abnormality of the fallopian tube |
| HP:0012125 | 2.73198472697e-05 | 0.6 | RAD50 NBN MRE11 | Prostate cancer |
| HP:0100787 | 2.73198472697e-05 | 0.6 | RAD50 NBN MRE11 | Prostate neoplasm |
| REAC:R-HSA-5693579 | 2.88749669481e-05 | 0.6 | RAD50 NBN MRE11 | Homologous DNA Pairing and Strand Exchange |
| GO:0030870 | 3.17736949706e-05 | 0.6 | RAD50 NBN MRE11 | Mre11 complex |
| WP:WP707 | 3.20197280625e-05 | 0.6 | RAD50 NBN MRE11 | DNA Damage Response |
| WP:WP1530 | 3.65771562028e-05 | 0.6 | RAD50 NBN MRE11 | miRNA Regulation of DNA Damage Response |
| WP:WP4016 | 5.07927414515e-05 | 0.6 | RAD50 NBN MRE11 | DNA IR-damage and cellular response via ATR |
| HP:0008775 | 5.09288575021e-05 | 0.6 | RAD50 NBN MRE11 | Abnormal prostate morphology |
| WP:WP438 | 7.00810045876e-05 | 0.4 | RAD50 MRE11 | Non-homologous end joining |
| REAC:R-HSA-5685942 | 0.000118030564163 | 0.6 | RAD50 NBN MRE11 | HDR through Homologous Recombination (HRR) |
| CORUM:1193 | 0.000140787732431 | 0.4 | RAD50 MRE11 | Rap1 complex |
| CORUM:2766 | 0.000140787732431 | 0.4 | RAD50 MRE11 | TERF2-RAP1 complex |
| HP:0000022 | 0.00014151146773 | 0.6 | RAD50 NBN MRE11 | Abnormality of male internal genitalia |
| REAC:R-HSA-5693571 | 0.000141520021869 | 0.6 | RAD50 NBN MRE11 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-5693565 | 0.000189751148448 | 0.6 | RAD50 NBN MRE11 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.000197423805207 | 0.6 | RAD50 NBN MRE11 | DNA Double Strand Break Response |
| REAC:R-HSA-2559586 | 0.000213382377717 | 0.6 | RAD50 NBN MRE11 | DNA Damage/Telomere Stress Induced Senescence |
| HP:0003002 | 0.000244346608078 | 0.6 | RAD50 NBN MRE11 | Breast carcinoma |
| REAC:R-HSA-912446 | 0.000266353842167 | 0.6 | RAD50 NBN MRE11 | Meiotic recombination |
| HP:0100615 | 0.000272465709143 | 0.6 | RAD50 NBN MRE11 | Ovarian neoplasm |
| HP:0002861 | 0.000287298458388 | 0.6 | RAD50 NBN MRE11 | Melanoma |
| WP:WP4262 | 0.000290626512492 | 0.6 | RAD50 NBN MRE11 | Breast cancer pathway |
| REAC:R-HSA-6804756 | 0.000327410819085 | 0.6 | RAD50 NBN MRE11 | Regulation of TP53 Activity through Phosphorylation |
| KEGG:03450 | 0.000334402895448 | 0.4 | RAD50 MRE11 | Non-homologous end-joining |
| REAC:R-HSA-69473 | 0.000361148609859 | 0.6 | RAD50 NBN MRE11 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.000397120285508 | 0.6 | RAD50 NBN MRE11 | Processing of DNA double-strand break ends |
| KEGG:04218 | 0.000424294655338 | 0.6 | RAD50 NBN MRE11 | Cellular senescence |
| HP:0002894 | 0.000554519771166 | 0.6 | RAD50 NBN MRE11 | Neoplasm of the pancreas |
| HP:0100013 | 0.000578226462924 | 0.6 | RAD50 NBN MRE11 | Neoplasm of the breast |
| REAC:R-HSA-1500620 | 0.000646560981801 | 0.6 | RAD50 NBN MRE11 | Meiosis |
| GO:0031954 | 0.000739960245213 | 0.6 | RAD50 NBN MRE11 | positive regulation of protein autophosphorylation |
| HP:0010785 | 0.000853340168558 | 0.6 | RAD50 NBN MRE11 | Gonadal neoplasm |
| REAC:R-HSA-1474165 | 0.000895201015071 | 0.6 | RAD50 NBN MRE11 | Reproduction |
| REAC:R-HSA-5693567 | 0.000960389260783 | 0.6 | RAD50 NBN MRE11 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.00110006319269 | 0.6 | RAD50 NBN MRE11 | Homology Directed Repair |
| GO:0000729 | 0.00160515829483 | 0.6 | RAD50 NBN MRE11 | DNA double-strand break processing |
| REAC:R-HSA-5633007 | 0.00169383519446 | 0.6 | RAD50 NBN MRE11 | Regulation of TP53 Activity |
| GO:0022616 | 0.00183428165932 | 0.6 | RAD50 NBN MRE11 | DNA strand elongation |
| REAC:R-HSA-5693532 | 0.00193087050228 | 0.6 | RAD50 NBN MRE11 | DNA Double-Strand Break Repair |
| HP:0010787 | 0.00199894912552 | 0.6 | RAD50 NBN MRE11 | Genital neoplasm |
| REAC:R-HSA-69481 | 0.00203883898451 | 0.6 | RAD50 NBN MRE11 | G2/M Checkpoints |
| REAC:R-HSA-2559583 | 0.00290844270817 | 0.6 | RAD50 NBN MRE11 | Cellular Senescence |
| WP:WP1971 | 0.00299893680898 | 0.4 | RAD50 MRE11 | Integrated Cancer Pathway |
| HP:0007379 | 0.00518810524287 | 0.6 | RAD50 NBN MRE11 | Neoplasm of the genitourinary tract |
| GO:0031952 | 0.005924931483 | 0.6 | RAD50 NBN MRE11 | regulation of protein autophosphorylation |
| WP:WP4656 | 0.00869264148791 | 0.4 | RAD50 MRE11 | Joubert Syndrome |
| HP:0000137 | 0.00954324061064 | 0.6 | RAD50 NBN MRE11 | Abnormality of the ovary |
| HP:0007378 | 0.0100146377786 | 0.6 | RAD50 NBN MRE11 | Neoplasm of the gastrointestinal tract |
| REAC:R-HSA-69620 | 0.0103005771752 | 0.6 | RAD50 NBN MRE11 | Cell Cycle Checkpoints |
| REAC:R-HSA-73894 | 0.0143782387474 | 0.6 | RAD50 NBN MRE11 | DNA Repair |
| GO:0032206 | 0.0156368617465 | 0.6 | RAD50 NBN MRE11 | positive regulation of telomere maintenance |
| HP:0001732 | 0.0158166348953 | 0.6 | RAD50 NBN MRE11 | Abnormality of the pancreas |
| REAC:R-HSA-3700989 | 0.0182828935298 | 0.6 | RAD50 NBN MRE11 | Transcriptional Regulation by TP53 |
| HP:0011792 | 0.0197787034757 | 0.6 | RAD50 NBN MRE11 | Neoplasm by histology |
| GO:0032508 | 0.0199719657189 | 0.6 | RAD50 NBN MRE11 | DNA duplex unwinding |
| GO:0016233 | 0.0211681462149 | 0.6 | RAD50 NBN MRE11 | telomere capping |
| GO:0035861 | 0.0237016209836 | 0.6 | RAD50 NBN MRE11 | site of double-strand break |
| GO:0003678 | 0.0264291737868 | 0.6 | RAD50 NBN MRE11 | DNA helicase activity |
| GO:0000019 | 0.0270421395626 | 0.4 | RAD50 MRE11 | regulation of mitotic recombination |
| REAC:R-HSA-2262752 | 0.0291077226575 | 0.6 | RAD50 NBN MRE11 | Cellular responses to stress |
| HP:0003220 | 0.0325153883173 | 0.4 | RAD50 NBN | Abnormality of chromosome stability |
| HP:0031093 | 0.0333025936722 | 0.6 | RAD50 NBN MRE11 | Abnormal breast morphology |
| HP:0000769 | 0.0333025936722 | 0.6 | RAD50 NBN MRE11 | Abnormality of the breast |
| WP:WP1984 | 0.0337317416567 | 0.4 | RAD50 MRE11 | Integrated Breast Cancer Pathway |
| GO:0032392 | 0.034143769383 | 0.6 | RAD50 NBN MRE11 | DNA geometric change |
| REAC:R-HSA-8953897 | 0.0498194225693 | 0.6 | RAD50 NBN MRE11 | Cellular responses to external stimuli |
| CORUM:2723 | 0.0499494897235 | 0.2 | NBN | ATM-NBN complex |
| CORUM:2776 | 0.0499494897235 | 0.2 | RAD50 | RAD50-BRCA1 complex |
| CORUM:7103 | 0.0499494897235 | 0.2 | NBN | NBS1-VRK1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NBN | RAD50 | 0.999 | 0.948 | bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| RAD50 | MRE11 | 0.991 | 0.911 | bioplex_WMM boldt Malo fraction boldt_WMM |
| NBN | FAM219A | 0.78 | 0.754 | bioplex (FAM219A) bioplex_WMM |
| RAD50 | FAM219A | 0.423 | 0.573 | bioplex (FAM219A) bioplex_WMM |
| MRE11 | FAM219A | 0.083 | 0.348 | bioplex (FAM219A) bioplex_WMM |
| MRE11 | HEATR1 | 0.057 | 0.322 | bioplex_WMM fraction |
| RAD50 | HEATR1 | 0.011 | 0.148 | youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| NBN | MRE11 | 0.008 | 0.096 | bioplex_WMM WMM_only |
| NBN | HEATR1 | 0.007 | 0.008 | youn_WMM WMM_only |
| FAM219A | HEATR1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01080 has an average edge precision of 0.411 which is ranked 3192 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NBN | HuMAP2_01080 HuMAP2_03572 HuMAP2_03801 HuMAP2_05113 |
| MRE11 | HuMAP2_01080 HuMAP2_02474 |
| HEATR1 | HuMAP2_01080 HuMAP2_02137 HuMAP2_02340 HuMAP2_04259 |
| FAM219A | HuMAP2_01080 HuMAP2_03572 HuMAP2_03801 HuMAP2_05113 |
| RAD50 | HuMAP2_01080 HuMAP2_02474 HuMAP2_03572 HuMAP2_05113 |