hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01092

Confidence: Medium

Genename	Protein Name	Links
DDOST	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit)	UniProt NCBI
TMEM258	Transmembrane protein 258 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258) (Oligosaccharyl transferase subunit TMEM258)	UniProt NCBI
EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)	UniProt NCBI
STT3A	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC)	UniProt NCBI
KDSR	3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1) (FVT-1) (Short chain dehydrogenase/reductase family 35C member 1)	UniProt NCBI
MLEC	Malectin	UniProt NCBI
SEC61A1	Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)	UniProt NCBI
SEC63	Translocation protein SEC63 homolog	UniProt NCBI
JAGN1	Protein jagunal homolog 1	UniProt NCBI
RPN2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04141	1.21554677457e-08	0.6	STT3A RPN2 SEC61A1 DDOST SEC63 EIF2AK3	Protein processing in endoplasmic reticulum
CORUM:1199	3.24009105225e-07	0.3	RPN2 STT3A DDOST	Oligosaccharyltransferase complex (Stt3A variant)
GO:0005789	3.48562031848e-07	0.9	STT3A DDOST SEC61A1 KDSR TMEM258 RPN2 SEC63 EIF2AK3 MLEC	endoplasmic reticulum membrane
GO:0042175	4.03566179784e-07	0.9	STT3A DDOST SEC61A1 KDSR TMEM258 RPN2 SEC63 EIF2AK3 MLEC	nuclear outer membrane-endoplasmic reticulum membrane network
GO:0005783	1.37371218639e-06	1.0	JAGN1 DDOST SEC61A1 KDSR TMEM258 RPN2 SEC63 EIF2AK3 MLEC STT3A	endoplasmic reticulum
GO:0008250	1.68680065522e-06	0.4	RPN2 DDOST TMEM258 STT3A	oligosaccharyltransferase complex
CORUM:6131	1.94131410987e-06	0.3	RPN2 STT3A DDOST	SELK multiprotein complex
GO:0044432	5.84611709687e-06	0.9	STT3A DDOST SEC61A1 KDSR TMEM258 RPN2 SEC63 EIF2AK3 MLEC	endoplasmic reticulum part
KEGG:00513	7.39545086655e-05	0.3	RPN2 STT3A DDOST	Various types of N-glycan biosynthesis
KEGG:00510	0.000136791504244	0.3	RPN2 STT3A DDOST	N-Glycan biosynthesis
CORUM:1200	0.000632835990272	0.2	RPN2 DDOST	Oligosaccharyltransferase complex (Stt3B variant)
GO:0004579	0.000913516286731	0.3	RPN2 STT3A DDOST	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0004576	0.00130456308183	0.3	RPN2 STT3A DDOST	oligosaccharyl transferase activity
GO:0006487	0.00408682796965	0.4	RPN2 DDOST TMEM258 STT3A	protein N-linked glycosylation
KEGG:03060	0.0048982296421	0.2	SEC61A1 SEC63	Protein export
REAC:R-HSA-446203	0.00526669270171	0.4	RPN2 DDOST MLEC STT3A	Asparagine N-linked glycosylation
GO:0012505	0.00946154548006	1.0	JAGN1 DDOST SEC61A1 KDSR TMEM258 RPN2 SEC63 EIF2AK3 MLEC STT3A	endomembrane system
REAC:R-HSA-1799339	0.00973605157338	0.3	RPN2 DDOST SEC61A1	SRP-dependent cotranslational protein targeting to membrane
GO:0031090	0.0212278717661	0.9	STT3A DDOST SEC61A1 KDSR TMEM258 RPN2 SEC63 EIF2AK3 MLEC	organelle membrane
GO:0018279	0.0438273782088	0.3	RPN2 STT3A DDOST	protein N-linked glycosylation via asparagine
GO:0018196	0.0485060473678	0.3	RPN2 STT3A DDOST	peptidyl-asparagine modification

Edges

Protein 1	Protein 2	Score	Precision	Evidence
RPN2	DDOST	0.998	0.944	bioplex (RPN2) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
STT3A	RPN2	0.22	0.466	hein_WMM bioplex (RPN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
RPN2	EIF2AK3	0.138	0.406	bioplex (RPN2) bioplex_WMM youn_WMM gupta_WMM
RPN2	MLEC	0.136	0.406	hein_WMM bioplex (RPN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
RPN2	TMEM258	0.105	0.37	bioplex (RPN2) bioplex_WMM
SEC61A1	DDOST	0.087	0.353	bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
JAGN1	DDOST	0.029	0.232	bioplex_WMM Guru youn_WMM gupta_WMM fraction
SEC61A1	SEC63	0.028	0.231	bioplex (SEC63) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM
JAGN1	SEC61A1	0.026	0.22	bioplex_WMM Guru youn_WMM gupta_WMM fraction
RPN2	KDSR	0.021	0.195	bioplex_WMM Guru boldt fraction boldt_WMM
STT3A	DDOST	0.011	0.143	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
TMEM258	DDOST	0.008	0.012	bioplex_WMM WMM_only
MLEC	DDOST	0.007	0.007	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
JAGN1	KDSR	0.007	0.009	bioplex_WMM WMM_only
EIF2AK3	SEC63	0.007	0.01	bioplex_WMM youn_WMM gupta_WMM WMM_only
EIF2AK3	TMEM258	0.007	0.005	bioplex_WMM WMM_only
EIF2AK3	JAGN1	0.007	0.006	youn_WMM gupta_WMM WMM_only
RPN2	JAGN1	0.007	0.001	bioplex_WMM youn_WMM gupta_WMM WMM_only
STT3A	JAGN1	0.007	0.004	bioplex_WMM youn_WMM gupta_WMM WMM_only
JAGN1	SEC63	0.007	0.0	youn_WMM gupta_WMM WMM_only
STT3A	TMEM258	0.007	0.001	bioplex_WMM WMM_only
TMEM258	KDSR	0.007	0.002	bioplex_WMM WMM_only
TMEM258	SEC61A1	0.007	0.003	bioplex_WMM WMM_only
MLEC	JAGN1	0.007	0.004	bioplex_WMM gupta_WMM WMM_only
MLEC	TMEM258	0.007	0.004	bioplex_WMM WMM_only
EIF2AK3	DDOST	0.007	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
EIF2AK3	SEC61A1	0.006	0.002	bioplex_WMM youn_WMM gupta_WMM WMM_only
EIF2AK3	KDSR	0.006	0.004	bioplex_WMM WMM_only
DDOST	KDSR	0.006	0.004	bioplex_WMM boldt boldt_WMM
STT3A	EIF2AK3	0.006	0.006	bioplex_WMM youn_WMM gupta_WMM WMM_only
RPN2	SEC61A1	0.006	0.007	bioplex (RPN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
STT3A	SEC61A1	0.005	0.013	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
MLEC	EIF2AK3	0.005	0.006	bioplex_WMM gupta_WMM WMM_only
SEC61A1	KDSR	0.005	0.011	bioplex_WMM boldt boldt_WMM
RPN2	SEC63	0.005	0.014	bioplex (RPN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
STT3A	SEC63	0.005	0.01	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
STT3A	KDSR	0.005	0.007	bioplex_WMM boldt boldt_WMM
SEC63	KDSR	0.005	0.009	bioplex_WMM boldt boldt_WMM
MLEC	SEC61A1	0.005	0.011	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
MLEC	KDSR	0.005	0.011	bioplex_WMM boldt boldt_WMM
STT3A	MLEC	0.004	0.014	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
MLEC	SEC63	0.004	0.01	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
SEC63	DDOST	0.004	0.017	bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM

Images

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Complex HuMAP2_01092 has an average edge precision of 0.098 which is ranked 6938 out of all 6965 complexes.

Related Complexes

Genename	Complexes
DDOST	HuMAP2_00906 HuMAP2_01092 HuMAP2_01521 HuMAP2_03276 HuMAP2_05228 HuMAP2_06982
TMEM258	HuMAP2_00485 HuMAP2_01092 HuMAP2_02727 HuMAP2_05631 HuMAP2_06974
EIF2AK3	HuMAP2_00485 HuMAP2_01092 HuMAP2_05631 HuMAP2_06974
STT3A	HuMAP2_00485 HuMAP2_01092 HuMAP2_02541 HuMAP2_05631 HuMAP2_06974
KDSR	HuMAP2_01092 HuMAP2_03970 HuMAP2_06380 HuMAP2_06974
MLEC	HuMAP2_00485 HuMAP2_01092 HuMAP2_06974
SEC61A1	HuMAP2_00906 HuMAP2_01092 HuMAP2_01521 HuMAP2_03276 HuMAP2_05574 HuMAP2_06982
SEC63	HuMAP2_00906 HuMAP2_01092 HuMAP2_01521 HuMAP2_03276 HuMAP2_06982
JAGN1	HuMAP2_00906 HuMAP2_01092 HuMAP2_01521 HuMAP2_03276 HuMAP2_06982
RPN2	HuMAP2_00485 HuMAP2_01092 HuMAP2_05228 HuMAP2_05631 HuMAP2_06974

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01092