hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01094

Confidence: Medium High

Genename	Protein Name	Links
AZIN2	Antizyme inhibitor 2 (AzI2) (Arginine decarboxylase) (ADC) (ARGDC) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p)	UniProt NCBI
AZIN1	Antizyme inhibitor 1 (AZI) (AZI1) (Ornithine decarboxylase antizyme inhibitor)	UniProt NCBI
FOXA1	Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A)	UniProt NCBI
OAZ1	Ornithine decarboxylase antizyme 1 (AZ1) (ODC-Az)	UniProt NCBI
OAZ2	Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0042979	6.09856266088e-10	0.8	OAZ2 OAZ1 AZIN1 AZIN2	ornithine decarboxylase regulator activity
GO:0006595	1.22034183608e-07	0.8	OAZ2 OAZ1 AZIN1 AZIN2	polyamine metabolic process
REAC:R-HSA-351202	1.43848058581e-07	0.8	OAZ2 OAZ1 AZIN1 AZIN2	Metabolism of polyamines
GO:0006576	1.65230232484e-05	0.8	OAZ2 OAZ1 AZIN1 AZIN2	cellular biogenic amine metabolic process
REAC:R-HSA-350562	5.63522070511e-05	0.6	OAZ2 AZIN1 OAZ1	Regulation of ornithine decarboxylase (ODC)
GO:0006596	0.000108905457596	0.6	OAZ1 AZIN1 AZIN2	polyamine biosynthetic process
REAC:R-HSA-71291	0.000217774869126	0.8	OAZ2 OAZ1 AZIN1 AZIN2	Metabolism of amino acids and derivatives
GO:0044106	0.000438392708191	0.8	OAZ2 OAZ1 AZIN1 AZIN2	cellular amine metabolic process
GO:0009308	0.0005799178998	0.8	OAZ2 OAZ1 AZIN1 AZIN2	amine metabolic process
GO:0042401	0.000616695699567	0.6	OAZ1 AZIN1 AZIN2	cellular biogenic amine biosynthetic process
GO:0009309	0.000739960245213	0.6	OAZ1 AZIN1 AZIN2	amine biosynthetic process
GO:0042978	0.00450823411379	0.4	AZIN1 AZIN2	ornithine decarboxylase activator activity
GO:1902269	0.00450823411379	0.4	AZIN1 AZIN2	positive regulation of polyamine transmembrane transport
GO:0033387	0.0135228859698	0.4	AZIN1 AZIN2	putrescine biosynthetic process from ornithine
GO:0008073	0.0135228859698	0.4	OAZ2 OAZ1	ornithine decarboxylase inhibitor activity
GO:1902267	0.0135228859698	0.4	AZIN1 AZIN2	regulation of polyamine transmembrane transport
GO:0006521	0.0250406933376	0.6	OAZ2 AZIN1 OAZ1	regulation of cellular amino acid metabolic process
GO:0009446	0.0270421395626	0.4	AZIN1 AZIN2	putrescine biosynthetic process
GO:1902047	0.0270421395626	0.4	AZIN1 AZIN2	polyamine transmembrane transport
GO:0033238	0.0308999432136	0.6	OAZ2 AZIN1 OAZ1	regulation of cellular amine metabolic process
MIRNA:hsa-miR-30d-5p	0.0350515280025	0.6	FOXA1 AZIN1 AZIN2	hsa-miR-30d-5p
GO:0006520	0.0366218592609	0.8	OAZ2 OAZ1 AZIN1 AZIN2	cellular amino acid metabolic process
GO:0042176	0.0376297096835	0.8	OAZ2 OAZ1 AZIN1 AZIN2	regulation of protein catabolic process
GO:0009445	0.0450641792523	0.4	AZIN1 AZIN2	putrescine metabolic process
GO:0015846	0.0450641792523	0.4	AZIN1 AZIN2	polyamine transport

Edges

Protein 1	Protein 2	Score	Precision	Evidence
OAZ2	AZIN2	0.995	0.924	bioplex (AZIN2) bioplex_WMM
AZIN2	OAZ1	0.994	0.919	bioplex (AZIN2) bioplex_WMM
OAZ2	AZIN1	0.992	0.911	bioplex (AZIN1) bioplex_WMM
AZIN1	OAZ1	0.981	0.896	hein_WMM bioplex (AZIN1) bioplex_WMM hein (OAZ1)
AZIN2	FOXA1	0.048	0.295	bioplex (AZIN2) bioplex_WMM
OAZ2	OAZ1	0.012	0.149	bioplex_WMM WMM_only
OAZ1	FOXA1	0.008	0.085	bioplex_WMM WMM_only
OAZ2	FOXA1	0.008	0.085	bioplex_WMM WMM_only

Images

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Complex HuMAP2_01094 has an average edge precision of 0.533 which is ranked 2318 out of all 6965 complexes.

Related Complexes

Genename	Complexes
AZIN2	HuMAP2_00289 HuMAP2_01094
AZIN1	HuMAP2_01094
FOXA1	HuMAP2_01094 HuMAP2_05080
OAZ1	HuMAP2_01094
OAZ2	HuMAP2_00289 HuMAP2_01094

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01094