hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01102
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ARHGAP17 | Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) | UniProt NCBI |
| MICALL1 | MICAL-like protein 1 (Molecule interacting with Rab13) (MIRab13) | UniProt NCBI |
| ASAP3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1) | UniProt NCBI |
| ASAP2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP) | UniProt NCBI |
| ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | UniProt NCBI |
| SYNJ2 | Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2) | UniProt NCBI |
| SH3KBP1 | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) | UniProt NCBI |
| STAP1 | Signal-transducing adaptor protein 1 (STAP-1) (BCR downstream-signaling protein 1) (Docking protein BRDG1) (Stem cell adaptor protein 1) | UniProt NCBI |
| RTKN2 | Rhotekin-2 (Pleckstrin homology domain-containing family K member 1) (PH domain-containing family K member 1) | UniProt NCBI |
| SH3BP1 | SH3 domain-binding protein 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04144 | 0.00052900177755 | 0.4 | ASAP2 ASAP1 SH3KBP1 ASAP3 | Endocytosis |
| CORUM:846 | 0.000632835990272 | 0.2 | SH3KBP1 ARHGAP17 | RICH1/AMOT polarity complex, Flag-Rich1 precipitated |
| KEGG:04666 | 0.00111593295957 | 0.3 | ASAP2 ASAP3 ASAP1 | Fc gamma R-mediated phagocytosis |
| GO:0005096 | 0.00219753919632 | 0.5 | ASAP2 SH3BP1 ASAP1 ARHGAP17 ASAP3 | GTPase activator activity |
| GO:0030695 | 0.00520760549616 | 0.5 | ASAP2 SH3BP1 ASAP1 ARHGAP17 ASAP3 | GTPase regulator activity |
| GO:0060589 | 0.0110720491317 | 0.5 | ASAP2 SH3BP1 ASAP1 ARHGAP17 ASAP3 | nucleoside-triphosphatase regulator activity |
| GO:0061024 | 0.0449301169297 | 0.6 | STAP1 SH3BP1 SH3KBP1 ASAP1 MICALL1 SYNJ2 | membrane organization |
| CORUM:3173 | 0.0499561984052 | 0.1 | SH3KBP1 | CIN85 homotetramer complex |
| CORUM:3174 | 0.0499561984052 | 0.1 | SH3KBP1 | CIN85-BLNK complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SH3KBP1 | STAP1 | 0.998 | 0.943 | bioplex (STAP1) bioplex_WMM |
| SH3BP1 | SH3KBP1 | 0.96 | 0.865 | bioplex (SH3KBP1) bioplex_WMM |
| SH3KBP1 | RTKN2 | 0.936 | 0.85 | bioplex (SH3KBP1) bioplex_WMM |
| SH3KBP1 | MICALL1 | 0.896 | 0.821 | bioplex (SH3KBP1) bioplex_WMM youn_WMM gupta_WMM |
| SH3KBP1 | ASAP1 | 0.513 | 0.632 | bioplex (SH3KBP1) bioplex_WMM gupta_WMM |
| SH3BP1 | ARHGAP17 | 0.492 | 0.621 | bioplex (ARHGAP17) bioplex_WMM |
| SH3KBP1 | ASAP2 | 0.425 | 0.575 | bioplex (SH3KBP1) bioplex_WMM |
| ASAP3 | ASAP2 | 0.143 | 0.405 | bioplex (ASAP3) bioplex_WMM |
| ASAP1 | ASAP3 | 0.124 | 0.396 | bioplex (ASAP3) bioplex_WMM |
| SH3KBP1 | SYNJ2 | 0.047 | 0.293 | bioplex (SH3KBP1) bioplex_WMM youn_WMM gupta_WMM |
| ARHGAP17 | SH3KBP1 | 0.026 | 0.221 | bioplex (SH3KBP1) bioplex_WMM youn_WMM |
| ASAP1 | ASAP2 | 0.013 | 0.155 | bioplex_WMM WMM_only |
| MICALL1 | SYNJ2 | 0.009 | 0.105 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| ASAP1 | SYNJ2 | 0.009 | 0.099 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RTKN2 | SYNJ2 | 0.009 | 0.092 | bioplex_WMM youn_WMM WMM_only |
| ARHGAP17 | SYNJ2 | 0.008 | 0.087 | bioplex_WMM youn_WMM WMM_only |
| RTKN2 | ASAP1 | 0.008 | 0.081 | bioplex_WMM youn_WMM WMM_only |
| MICALL1 | RTKN2 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| SYNJ2 | ASAP2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| MICALL1 | ASAP1 | 0.008 | 0.082 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SH3BP1 | SYNJ2 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| ARHGAP17 | MICALL1 | 0.008 | 0.075 | bioplex_WMM youn_WMM WMM_only |
| MICALL1 | ASAP2 | 0.008 | 0.059 | bioplex_WMM WMM_only |
| RTKN2 | ASAP2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SH3BP1 | MICALL1 | 0.008 | 0.049 | bioplex_WMM WMM_only |
| SH3BP1 | RTKN2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| ARHGAP17 | RTKN2 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| SH3BP1 | ASAP1 | 0.008 | 0.029 | bioplex_WMM WMM_only |
| ARHGAP17 | ASAP1 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| SH3BP1 | ASAP2 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| ARHGAP17 | ASAP2 | 0.008 | 0.011 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01102 has an average edge precision of 0.258 which is ranked 5261 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ARHGAP17 | HuMAP2_00511 HuMAP2_01102 |
| MICALL1 | HuMAP2_00974 HuMAP2_01102 HuMAP2_01103 HuMAP2_01661 HuMAP2_02945 HuMAP2_04010 HuMAP2_06001 HuMAP2_06285 HuMAP2_06775 |
| ASAP3 | HuMAP2_01102 HuMAP2_02246 HuMAP2_03828 HuMAP2_06714 |
| ASAP2 | HuMAP2_01102 HuMAP2_03828 |
| ASAP1 | HuMAP2_00974 HuMAP2_01102 HuMAP2_03828 HuMAP2_06714 |
| SYNJ2 | HuMAP2_01102 |
| SH3KBP1 | HuMAP2_00974 HuMAP2_01102 HuMAP2_01103 HuMAP2_02945 HuMAP2_04010 HuMAP2_06775 |
| STAP1 | HuMAP2_01102 HuMAP2_02945 HuMAP2_04010 |
| RTKN2 | HuMAP2_00974 HuMAP2_01102 HuMAP2_01103 HuMAP2_02945 HuMAP2_03143 HuMAP2_04010 HuMAP2_05697 HuMAP2_06775 |
| SH3BP1 | HuMAP2_00511 HuMAP2_01102 HuMAP2_01103 HuMAP2_01397 |