hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01115
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | UniProt NCBI |
| CTC1 | CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) | UniProt NCBI |
| TEN1 | CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog) | UniProt NCBI |
| STN1 | CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6075 | 6.75231048499e-10 | 0.75 | CTC1 TEN1 STN1 | CST complex |
| GO:1990879 | 3.63274304092e-07 | 0.75 | CTC1 TEN1 STN1 | CST complex |
| GO:0000782 | 7.98841194917e-05 | 0.75 | CTC1 TEN1 STN1 | telomere cap complex |
| GO:0000783 | 7.98841194917e-05 | 0.75 | CTC1 TEN1 STN1 | nuclear telomere cap complex |
| GO:0000784 | 0.000187207512548 | 1.0 | CTC1 STN1 TEN1 ORC3 | nuclear chromosome, telomeric region |
| GO:0032993 | 0.000342608092204 | 1.0 | CTC1 STN1 TEN1 ORC3 | protein-DNA complex |
| GO:0000781 | 0.000363289575714 | 1.0 | CTC1 STN1 TEN1 ORC3 | chromosome, telomeric region |
| GO:0032211 | 0.000413778117181 | 0.75 | CTC1 TEN1 STN1 | negative regulation of telomere maintenance via telomerase |
| GO:1904357 | 0.00106129291317 | 0.75 | CTC1 TEN1 STN1 | negative regulation of telomere maintenance via telomere lengthening |
| GO:2000279 | 0.00147288799354 | 0.75 | CTC1 TEN1 STN1 | negative regulation of DNA biosynthetic process |
| GO:0032205 | 0.00237379826551 | 0.75 | CTC1 TEN1 STN1 | negative regulation of telomere maintenance |
| GO:0042162 | 0.0025894674696 | 0.75 | CTC1 TEN1 STN1 | telomeric DNA binding |
| HP:0007763 | 0.00272425312749 | 0.5 | CTC1 STN1 | Retinal telangiectasia |
| GO:0098687 | 0.00552286185544 | 1.0 | CTC1 STN1 TEN1 ORC3 | chromosomal region |
| GO:0032210 | 0.00754689803038 | 0.75 | CTC1 TEN1 STN1 | regulation of telomere maintenance via telomerase |
| GO:0016233 | 0.00848863295691 | 0.75 | CTC1 TEN1 STN1 | telomere capping |
| HP:0002216 | 0.00920632571228 | 0.5 | CTC1 STN1 | Premature graying of hair |
| GO:1904356 | 0.011776375189 | 0.75 | CTC1 TEN1 STN1 | regulation of telomere maintenance via telomere lengthening |
| GO:0007004 | 0.017346559408 | 0.75 | CTC1 TEN1 STN1 | telomere maintenance via telomerase |
| GO:0006278 | 0.0181462528862 | 0.75 | CTC1 TEN1 STN1 | RNA-dependent DNA biosynthetic process |
| GO:0032204 | 0.0254442868917 | 0.75 | CTC1 TEN1 STN1 | regulation of telomere maintenance |
| GO:0006275 | 0.0275320606423 | 0.75 | CTC1 ORC3 STN1 | regulation of DNA replication |
| GO:0010833 | 0.0275320606423 | 0.75 | CTC1 TEN1 STN1 | telomere maintenance via telomere lengthening |
| GO:2000278 | 0.0396936057372 | 0.75 | CTC1 TEN1 STN1 | regulation of DNA biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TEN1 | STN1 | 0.857 | 0.794 | bioplex (STN1,TEN1) bioplex_WMM |
| CTC1 | STN1 | 0.683 | 0.711 | bioplex (STN1) bioplex_WMM |
| CTC1 | TEN1 | 0.13 | 0.401 | hein_WMM bioplex (TEN1) bioplex_WMM hein (TEN1) |
| ORC3 | STN1 | 0.042 | 0.27 | bioplex (STN1) bioplex_WMM |
| ORC3 | TEN1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| ORC3 | CTC1 | 0.008 | 0.069 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01115 has an average edge precision of 0.39 which is ranked 3423 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ORC3 | HuMAP2_00864 HuMAP2_01115 HuMAP2_02994 HuMAP2_04533 HuMAP2_04597 |
| CTC1 | HuMAP2_01050 HuMAP2_01115 |
| TEN1 | HuMAP2_01050 HuMAP2_01115 HuMAP2_02935 |
| STN1 | HuMAP2_01050 HuMAP2_01115 HuMAP2_02935 |