hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01125
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDK7 | Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) | UniProt NCBI |
| ERCC5 | DNA repair protein complementing XP-G cells (EC 3.1.-.-) (DNA excision repair protein ERCC-5) (Xeroderma pigmentosum group G-complementing protein) | UniProt NCBI |
| MNAT1 | CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) | UniProt NCBI |
| CCNH | Cyclin-H (MO15-associated protein) (p34) (p37) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1010 | 6.75231048499e-10 | 0.75 | CDK7 CCNH MNAT1 | CAK complex (Cdk-activating kinase complex) |
| CORUM:1008 | 6.75231048499e-10 | 0.75 | CDK7 CCNH MNAT1 | CAK complex (Cdk-activating kinase complex) |
| KEGG:03420 | 2.45312729563e-09 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | Nucleotide excision repair |
| CORUM:1030 | 2.70078815927e-09 | 0.75 | CDK7 CCNH MNAT1 | CAK-ERCC2 complex |
| CORUM:2660 | 2.70078815927e-09 | 0.75 | CDK7 CCNH MNAT1 | CAK-ERCC2 complex |
| REAC:R-HSA-5696395 | 1.11920305816e-08 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | Formation of Incision Complex in GG-NER |
| CORUM:2657 | 1.3502580449e-08 | 0.75 | CDK7 CCNH MNAT1 | ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex |
| CORUM:1036 | 5.67022676981e-08 | 0.75 | CDK7 CCNH MNAT1 | TFIIH transcription factor complex |
| CORUM:107 | 5.67022676981e-08 | 0.75 | CDK7 CCNH MNAT1 | TFIIH transcription factor complex |
| REAC:R-HSA-6782135 | 6.14006351589e-08 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | Dual incision in TC-NER |
| CORUM:1029 | 8.09991585269e-08 | 0.75 | CDK7 CCNH MNAT1 | TFIIH transcription factor complex |
| CORUM:1009 | 8.09991585269e-08 | 0.75 | CDK7 CCNH MNAT1 | TFIIH transcription factor complex |
| REAC:R-HSA-6781827 | 1.29362225284e-07 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 1.74986096744e-07 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0019907 | 3.63274304092e-07 | 0.75 | CDK7 CCNH MNAT1 | cyclin-dependent protein kinase activating kinase holoenzyme complex |
| REAC:R-HSA-5696398 | 5.23569103583e-07 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | Nucleotide Excision Repair |
| GO:0006294 | 5.79418977671e-07 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | nucleotide-excision repair, preincision complex assembly |
| GO:0150005 | 1.45302402969e-06 | 0.75 | CDK7 CCNH MNAT1 | enzyme activator complex |
| WP:WP405 | 2.40067855039e-06 | 0.75 | CDK7 CCNH MNAT1 | Eukaryotic Transcription Initiation |
| KEGG:03022 | 3.08310905588e-06 | 0.75 | CDK7 CCNH MNAT1 | Basal transcription factors |
| REAC:R-HSA-69273 | 3.10262114446e-06 | 0.75 | CDK7 CCNH MNAT1 | Cyclin A/B1/B2 associated events during G2/M transition |
| REAC:R-HSA-77075 | 3.94532681474e-06 | 0.75 | CDK7 CCNH MNAT1 | RNA Pol II CTD phosphorylation and interaction with CE |
| REAC:R-HSA-167160 | 3.94532681474e-06 | 0.75 | CDK7 CCNH MNAT1 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| REAC:R-HSA-72086 | 4.92812658075e-06 | 0.75 | CDK7 CCNH MNAT1 | mRNA Capping |
| CORUM:1007 | 5.02777038712e-06 | 0.5 | CCNH CDK7 | CAK core complex (Cdk-activating kinase core complex) |
| REAC:R-HSA-73863 | 6.06176646053e-06 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase I Transcription Termination |
| REAC:R-HSA-167158 | 7.35698811902e-06 | 0.75 | CDK7 CCNH MNAT1 | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-113418 | 7.35698811902e-06 | 0.75 | CDK7 CCNH MNAT1 | Formation of the Early Elongation Complex |
| WP:WP45 | 8.93316220103e-06 | 0.75 | CDK7 CCNH MNAT1 | G1 to S cell cycle control |
| REAC:R-HSA-69236 | 1.54728521392e-05 | 0.75 | CDK7 CCNH MNAT1 | G1 Phase |
| REAC:R-HSA-69231 | 1.54728521392e-05 | 0.75 | CDK7 CCNH MNAT1 | Cyclin D associated events in G1 |
| REAC:R-HSA-167200 | 1.78485863117e-05 | 0.75 | CDK7 CCNH MNAT1 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167169 | 1.78485863117e-05 | 0.75 | CDK7 CCNH MNAT1 | HIV Transcription Elongation |
| REAC:R-HSA-167246 | 1.78485863117e-05 | 0.75 | CDK7 CCNH MNAT1 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167152 | 2.0455616978e-05 | 0.75 | CDK7 CCNH MNAT1 | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-73779 | 2.1849215234e-05 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-73762 | 2.1849215234e-05 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase I Transcription Initiation |
| REAC:R-HSA-73776 | 2.1849215234e-05 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-75953 | 2.1849215234e-05 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-167161 | 2.1849215234e-05 | 0.75 | CDK7 CCNH MNAT1 | HIV Transcription Initiation |
| REAC:R-HSA-76042 | 2.1849215234e-05 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-167162 | 2.1849215234e-05 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase II HIV Promoter Escape |
| GO:0006283 | 2.65528608423e-05 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | transcription-coupled nucleotide-excision repair |
| REAC:R-HSA-6781823 | 3.15562563454e-05 | 0.75 | CDK7 CCNH MNAT1 | Formation of TC-NER Pre-Incision Complex |
| REAC:R-HSA-73894 | 3.93749583955e-05 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | DNA Repair |
| REAC:R-HSA-112382 | 4.37783464274e-05 | 0.75 | CDK7 CCNH MNAT1 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 4.37783464274e-05 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-6796648 | 5.0922703922e-05 | 0.75 | CDK7 CCNH MNAT1 | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-6782210 | 5.60927864057e-05 | 0.75 | CDK7 CCNH MNAT1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-167172 | 7.69213089466e-05 | 0.75 | CDK7 CCNH MNAT1 | Transcription of the HIV genome |
| GO:0005675 | 7.98841194917e-05 | 0.75 | CDK7 CCNH MNAT1 | transcription factor TFIIH holo complex |
| GO:0019908 | 7.98841194917e-05 | 0.75 | CDK7 CCNH MNAT1 | nuclear cyclin-dependent protein kinase holoenzyme complex |
| GO:0006289 | 0.000116616394242 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | nucleotide-excision repair |
| REAC:R-HSA-69202 | 0.000119121057505 | 0.75 | CDK7 CCNH MNAT1 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-674695 | 0.000119121057505 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-69656 | 0.00012815247216 | 0.75 | CDK7 CCNH MNAT1 | Cyclin A:Cdk2-associated events at S phase entry |
| REAC:R-HSA-73772 | 0.000157957097998 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase I Promoter Escape |
| REAC:R-HSA-427413 | 0.000251857070121 | 0.75 | CDK7 CCNH MNAT1 | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 0.000274246893806 | 0.75 | CDK7 CCNH MNAT1 | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 0.00028199431919 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 0.000289886022463 | 0.75 | CDK7 CCNH MNAT1 | RNA Polymerase I Transcription |
| GO:0008353 | 0.000296207880886 | 0.75 | CDK7 CCNH MNAT1 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| GO:0032806 | 0.000351729129078 | 0.75 | CDK7 CCNH MNAT1 | carboxy-terminal domain protein kinase complex |
| REAC:R-HSA-8939236 | 0.000436852235365 | 0.75 | CDK7 CCNH MNAT1 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| REAC:R-HSA-69206 | 0.000480050915503 | 0.75 | CDK7 CCNH MNAT1 | G1/S Transition |
| REAC:R-HSA-162599 | 0.000514250934249 | 0.75 | CDK7 CCNH MNAT1 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 0.000681200950707 | 0.75 | CDK7 CCNH MNAT1 | HIV Life Cycle |
| REAC:R-HSA-212165 | 0.000681200950707 | 0.75 | CDK7 CCNH MNAT1 | Epigenetic regulation of gene expression |
| REAC:R-HSA-453279 | 0.000695357358954 | 0.75 | CDK7 CCNH MNAT1 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 0.000880763368668 | 0.75 | CDK7 CCNH MNAT1 | S Phase |
| GO:0065004 | 0.00125624335733 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | protein-DNA complex assembly |
| GO:0006362 | 0.00132566605022 | 0.75 | CDK7 CCNH MNAT1 | transcription elongation from RNA polymerase I promoter |
| REAC:R-HSA-69275 | 0.00150520149981 | 0.75 | CDK7 CCNH MNAT1 | G2/M Transition |
| REAC:R-HSA-453274 | 0.00155333604228 | 0.75 | CDK7 CCNH MNAT1 | Mitotic G2-G2/M phases |
| GO:0006363 | 0.00163061517788 | 0.75 | CDK7 CCNH MNAT1 | termination of RNA polymerase I transcription |
| GO:0006370 | 0.00179920875514 | 0.75 | CDK7 CCNH MNAT1 | 7-methylguanosine mRNA capping |
| GO:0006361 | 0.00179920875514 | 0.75 | CDK7 CCNH MNAT1 | transcription initiation from RNA polymerase I promoter |
| GO:0009452 | 0.00179920875514 | 0.75 | CDK7 CCNH MNAT1 | 7-methylguanosine RNA capping |
| GO:0036260 | 0.00197902980402 | 0.75 | CDK7 CCNH MNAT1 | RNA capping |
| REAC:R-HSA-8878171 | 0.00230643324807 | 0.75 | CDK7 CCNH MNAT1 | Transcriptional regulation by RUNX1 |
| GO:0000307 | 0.00237379826551 | 0.75 | CDK7 CCNH MNAT1 | cyclin-dependent protein kinase holoenzyme complex |
| REAC:R-HSA-162906 | 0.00243524237836 | 0.75 | CDK7 CCNH MNAT1 | HIV Infection |
| GO:0070985 | 0.00270494046827 | 0.5 | CCNH CDK7 | transcription factor TFIIK complex |
| GO:0071824 | 0.00307362739117 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | protein-DNA complex subunit organization |
| REAC:R-HSA-3700989 | 0.00924066477779 | 0.75 | CDK7 CCNH MNAT1 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-5663205 | 0.0100576606226 | 0.75 | CDK7 CCNH MNAT1 | Infectious disease |
| WP:WP179 | 0.0110921279178 | 0.5 | CCNH CDK7 | Cell Cycle |
| GO:0006360 | 0.011776375189 | 0.75 | CDK7 CCNH MNAT1 | transcription by RNA polymerase I |
| KEGG:04110 | 0.0141554312811 | 0.5 | CCNH CDK7 | Cell cycle |
| GO:0000079 | 0.0206918321066 | 0.75 | CDK7 CCNH MNAT1 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:0016591 | 0.0215903857674 | 0.75 | CDK7 CCNH MNAT1 | RNA polymerase II, holoenzyme |
| GO:0006353 | 0.0225145500348 | 0.75 | CDK7 CCNH MNAT1 | DNA-templated transcription, termination |
| GO:1904029 | 0.023464682987 | 0.75 | CDK7 CCNH MNAT1 | regulation of cyclin-dependent protein kinase activity |
| GO:1902554 | 0.023464682987 | 0.75 | CDK7 CCNH MNAT1 | serine/threonine protein kinase complex |
| GO:0006368 | 0.0286174056273 | 0.75 | CDK7 CCNH MNAT1 | transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-69278 | 0.0299490115235 | 0.75 | CDK7 CCNH MNAT1 | Cell Cycle, Mitotic |
| GO:1902911 | 0.0396936057372 | 0.75 | CDK7 CCNH MNAT1 | protein kinase complex |
| GO:0006281 | 0.042993565242 | 1.0 | ERCC5 CDK7 CCNH MNAT1 | DNA repair |
| GO:0008094 | 0.0454154921687 | 0.75 | CDK7 CCNH MNAT1 | DNA-dependent ATPase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCNH | MNAT1 | 1.0 | 0.949 | hein_WMM bioplex (CCNH,MNAT1) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| CCNH | CDK7 | 0.948 | 0.857 | hein_WMM bioplex (CCNH,CDK7) bioplex_WMM youn_WMM Malo fraction |
| CCNH | ERCC5 | 0.82 | 0.773 | hein_WMM bioplex (CCNH) bioplex_WMM |
| MNAT1 | CDK7 | 0.779 | 0.753 | hein_WMM bioplex (CDK7,MNAT1) bioplex_WMM youn_WMM Malo fraction |
| ERCC5 | CDK7 | 0.012 | 0.148 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ERCC5 | MNAT1 | 0.011 | 0.145 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01125 has an average edge precision of 0.604 which is ranked 1923 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDK7 | HuMAP2_01125 HuMAP2_01967 HuMAP2_04709 HuMAP2_04784 |
| ERCC5 | HuMAP2_01125 HuMAP2_01967 HuMAP2_04709 HuMAP2_06407 |
| MNAT1 | HuMAP2_01125 HuMAP2_01967 HuMAP2_04709 |
| CCNH | HuMAP2_01125 HuMAP2_01967 HuMAP2_04709 |