hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01127
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SGCE | Epsilon-sarcoglycan (Epsilon-SG) | UniProt NCBI |
| DUSP7 | Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2) | UniProt NCBI |
| FCGRT | IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor) | UniProt NCBI |
| DUSP9 | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | UniProt NCBI |
| LDLR | Low-density lipoprotein receptor (LDL receptor) | UniProt NCBI |
| PRTG | Protogenin (Protein Shen-Dan) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-112409 | 0.00377982352449 | 0.333333333333 | DUSP9 DUSP7 | RAF-independent MAPK1/3 activation |
| REAC:R-HSA-5675221 | 0.0146740061797 | 0.333333333333 | DUSP9 DUSP7 | Negative regulation of MAPK pathway |
| WP:WP2846 | 0.0332875339197 | 0.166666666667 | LDLR | Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation |
| WP:WP3408 | 0.0332875339197 | 0.166666666667 | LDLR | Evolocumab Mechanism |
| GO:0017017 | 0.0405595771497 | 0.333333333333 | DUSP9 DUSP7 | MAP kinase tyrosine/serine/threonine phosphatase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DUSP7 | DUSP9 | 1.0 | 0.949 | bioplex (DUSP7) bioplex_WMM |
| DUSP9 | FCGRT | 0.105 | 0.369 | bioplex (FCGRT) bioplex_WMM |
| FCGRT | PRTG | 0.042 | 0.269 | bioplex (FCGRT) bioplex_WMM |
| LDLR | FCGRT | 0.03 | 0.235 | bioplex (FCGRT) bioplex_WMM |
| FCGRT | SGCE | 0.028 | 0.231 | bioplex (FCGRT) bioplex_WMM |
| SGCE | PRTG | 0.01 | 0.128 | bioplex_WMM WMM_only |
| DUSP9 | PRTG | 0.008 | 0.067 | bioplex_WMM WMM_only |
| DUSP9 | SGCE | 0.008 | 0.06 | bioplex_WMM WMM_only |
| LDLR | PRTG | 0.007 | 0.011 | bioplex_WMM WMM_only |
| LDLR | SGCE | 0.007 | 0.004 | bioplex_WMM WMM_only |
| DUSP9 | LDLR | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01127 has an average edge precision of 0.212 which is ranked 5997 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SGCE | HuMAP2_01127 HuMAP2_01192 HuMAP2_02142 HuMAP2_04746 |
| DUSP7 | HuMAP2_00360 HuMAP2_01127 |
| FCGRT | HuMAP2_01127 HuMAP2_06279 |
| DUSP9 | HuMAP2_00360 HuMAP2_01127 |
| LDLR | HuMAP2_01127 HuMAP2_02673 HuMAP2_04155 |
| PRTG | HuMAP2_01127 HuMAP2_02142 HuMAP2_04746 HuMAP2_06279 |