hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01130
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSPA9 | Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74) | UniProt NCBI |
| HSPA8 | Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) | UniProt NCBI |
| PABPC1 | Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1308 | 2.01342304124e-05 | 0.666666666667 | HSPA8 PABPC1 | PABPC1-HSPA8-HNRPD-EIF4G1 complex |
| KEGG:03018 | 0.00127210962765 | 0.666666666667 | HSPA9 PABPC1 | RNA degradation |
| WP:WP2359 | 0.00205158647954 | 0.666666666667 | HSPA9 HSPA8 | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-450408 | 0.00920519282533 | 0.666666666667 | HSPA8 PABPC1 | AUF1 (hnRNP D0) binds and destabilizes mRNA |
| REAC:R-HSA-3371453 | 0.0138871493871 | 0.666666666667 | HSPA9 HSPA8 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-450531 | 0.0232544758505 | 0.666666666667 | HSPA8 PABPC1 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| REAC:R-HSA-3371556 | 0.0238137546255 | 0.666666666667 | HSPA9 HSPA8 | Cellular response to heat stress |
| MIRNA:hsa-miR-4307 | 0.049741469638 | 0.666666666667 | HSPA8 PABPC1 | hsa-miR-4307 |
| CORUM:6114 | 0.0499776345577 | 0.333333333333 | HSPA8 | BAG1-HSC70 complex |
| CORUM:7124 | 0.0499776345577 | 0.333333333333 | HSPA9 | HSPA9-GRPEL1 complex |
| CORUM:7125 | 0.0499776345577 | 0.333333333333 | HSPA9 | HSPA9-GRPEL2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HSPA9 | HSPA8 | 0.998 | 0.937 | bioplex (HSPA8,HSPA9) bioplex_WMM boldt Malo fraction boldt_WMM treiber_WMM |
| HSPA9 | PABPC1 | 0.998 | 0.937 | youn (PABPC1) bioplex (HSPA9) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| HSPA8 | PABPC1 | 0.995 | 0.924 | youn (PABPC1) bioplex (HSPA8) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_01130 has an average edge precision of 0.933 which is ranked 427 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSPA9 | HuMAP2_00358 HuMAP2_01130 |
| HSPA8 | HuMAP2_01130 HuMAP2_05624 |
| PABPC1 | HuMAP2_01130 HuMAP2_04393 HuMAP2_05559 HuMAP2_05734 HuMAP2_06735 |