hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01135
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TERF1 | Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) | UniProt NCBI |
| TINF2 | TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1202 | 5.02777038712e-06 | 1.0 | TERF1 TINF2 | TRF1 telomere length regulation complex |
| CORUM:1201 | 1.00555407742e-05 | 1.0 | TERF1 TINF2 | TRF1-TIN2 complex |
| CORUM:1206 | 2.51388519356e-05 | 1.0 | TERF1 TINF2 | TRF-Rap1 complex I, 2MD |
| CORUM:1197 | 2.51388519356e-05 | 1.0 | TERF1 TINF2 | Telomere-associated protein complex |
| CORUM:138 | 2.51388519356e-05 | 1.0 | TERF1 TINF2 | Telomere-associated protein complex |
| CORUM:1204 | 3.51943927099e-05 | 1.0 | TERF1 TINF2 | Rap1 complex |
| REAC:R-HSA-171306 | 0.00213680241453 | 1.0 | TERF1 TINF2 | Packaging Of Telomere Ends |
| REAC:R-HSA-110330 | 0.00239824647466 | 1.0 | TERF1 TINF2 | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-110331 | 0.00239824647466 | 1.0 | TERF1 TINF2 | Cleavage of the damaged purine |
| REAC:R-HSA-73927 | 0.00239824647466 | 1.0 | TERF1 TINF2 | Depurination |
| REAC:R-HSA-110328 | 0.00277030148331 | 1.0 | TERF1 TINF2 | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| REAC:R-HSA-73928 | 0.00277030148331 | 1.0 | TERF1 TINF2 | Depyrimidination |
| REAC:R-HSA-110329 | 0.00277030148331 | 1.0 | TERF1 TINF2 | Cleavage of the damaged pyrimidine |
| REAC:R-HSA-73929 | 0.00286750504412 | 1.0 | TERF1 TINF2 | Base-Excision Repair, AP Site Formation |
| REAC:R-HSA-1221632 | 0.00465068760809 | 1.0 | TERF1 TINF2 | Meiotic synapsis |
| REAC:R-HSA-2559586 | 0.00516352018758 | 1.0 | TERF1 TINF2 | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-157579 | 0.00542999201809 | 1.0 | TERF1 TINF2 | Telomere Maintenance |
| REAC:R-HSA-73884 | 0.00626962967274 | 1.0 | TERF1 TINF2 | Base Excision Repair |
| GO:0070187 | 0.00676235117068 | 1.0 | TERF1 TINF2 | shelterin complex |
| REAC:R-HSA-73886 | 0.0096834857656 | 1.0 | TERF1 TINF2 | Chromosome Maintenance |
| REAC:R-HSA-1500620 | 0.0107946230212 | 1.0 | TERF1 TINF2 | Meiosis |
| REAC:R-HSA-1474165 | 0.0134090636225 | 1.0 | TERF1 TINF2 | Reproduction |
| CORUM:2219 | 0.0249595281251 | 0.5 | TERF1 | TERF1 homodimer complex |
| REAC:R-HSA-2559583 | 0.0294593826216 | 1.0 | TERF1 TINF2 | Cellular Senescence |
| GO:0000782 | 0.029754345151 | 1.0 | TERF1 TINF2 | telomere cap complex |
| GO:0000783 | 0.029754345151 | 1.0 | TERF1 TINF2 | nuclear telomere cap complex |
| HP:0007617 | 0.0497341708567 | 0.5 | TINF2 | Fine, reticulate skin pigmentation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TINF2 | TERF1 | 1.0 | 0.949 | hein_WMM bioplex (TERF1,TINF2) bioplex_WMM hein (TERF1) |
Images
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Complex HuMAP2_01135 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TERF1 | HuMAP2_01135 HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271 |
| TINF2 | HuMAP2_01135 HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271 |